Nonproton ligand sensing domain is required for paradoxical stimulation of acid-sensing ion channel 3 (ASIC3) channels by amiloride (Q35604972)

9 August 2017

Nonproton ligand sensing domain is required for paradoxical stimulation of acid-sensing ion channel 3 (ASIC3) channels by amiloride (English)

1 reference

9 August 2017

1 reference

Wei-Guang Li

1

1 reference

9 August 2017

Ye Yu

2

1 reference

9 August 2017

Chen Huang

3

1 reference

9 August 2017

Hui Cao

4

1 reference

9 August 2017

Tian-Le Xu

5

1 reference

9 August 2017

language of work or name

English

0 references

publication date

13 October 2011

1 reference

Journal of Biological Chemistry

9 August 2017

12

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based on heuristic

inferred from page(s)

published in

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9 August 2017

286

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9 August 2017

49

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9 August 2017

42635-42646

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ASIC3 channels in multimodal sensory perception

9 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

Atomic level characterization of the nonproton ligand-sensing domain of ASIC3 channels.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domain

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

Small molecule ion channel match making: a natural fit for new ASIC ligands.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

Acid-sensing ion channels (ASICs): pharmacology and implication in pain

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

Leu85 in the beta1-beta2 linker of ASIC1 slows activation and decreases the apparent proton affinity by stabilizing a closed conformation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

Amiloride docking to acid-sensing ion channel-1

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

ASIC3, a sensor of acidic and primary inflammatory pain

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

Seizure termination by acidosis depends on ASIC1a

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

A tarantula peptide against pain via ASIC1a channels and opioid mechanisms

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

A conformation change in the extracellular domain that accompanies desensitization of acid-sensing ion channel (ASIC) 3.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

Acid-sensing ion channels: advances, questions and therapeutic opportunities.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

Sustained currents through ASIC3 ion channels at the modest pH changes that occur during myocardial ischemia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory function

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

The ASICs: signaling molecules? Modulators?

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

Inhibition of glycine response by amiloride in rat spinal neurons

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

A role for ASIC3 in the modulation of high-intensity pain stimuli

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

Selective modulation of heteromeric ASIC proton-gated channels by neuropeptide FF.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

Amiloride and its analogs as tools to inhibit Na+ transport via the Na+ channel, the Na+/H+ antiport and the Na+/Ca2+ exchanger

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234944

A proton-gated cation channel involved in acid-sensing

27 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.289058

Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.289058

The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.289058

The mammalian sodium channel BNC1 is required for normal touch sensation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.289058

Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.289058

Calcium-permeable acid-sensing ion channel in nociceptive plasticity: a new target for pain control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.289058

Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.289058

Paradoxical stimulation of a DEG/ENaC channel by amiloride.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.289058

Protons activate brain Na+ channel 1 by inducing a conformational change that exposes a residue associated with neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.289058

A nonproton ligand sensor in the acid-sensing ion channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.289058

Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.289058

The interaction between two extracellular linker regions controls sustained opening of acid-sensing ion channel 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.289058

Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.289058

Structural elements for the generation of sustained currents by the acid pain sensor ASIC3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.289058

Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.289058

Strong modulation by RFamide neuropeptides of the ASIC1b/3 heteromer in competition with extracellular calcium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.289058

Asn415 in the beta11-beta12 linker decreases proton-dependent desensitization of ASIC1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.289058

Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.289058

Amiloride selectively blocks the low threshold (T) calcium channel

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21998313

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M111.289058

1 reference

9 August 2017

1 reference

9 August 2017

1 reference