Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model (Q35605388)

9 August 2017

Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model (English)

1 reference

9 August 2017

1 reference

Franziska Brandes

1

1 reference

9 August 2017

Katharina Schmidt

2

1 reference

9 August 2017

Christine Wagner

3

1 reference

9 August 2017

Julia Redekopf

4

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9 August 2017

Hans Jürgen Schlitt

5

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9 August 2017

Edward Kenneth Geissler

6

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9 August 2017

Sven Arke Lang

7

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9 August 2017

language of work or name

English

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publication date

19 February 2015

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9 August 2017

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9 August 2017

15

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9 August 2017

71

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Creative Commons Attribution 4.0 International

9 August 2017

start time

19 February 2015

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4340491/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1186/s12885-015-1064-9

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cites work

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The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem cell signaling in pancreatic cancer

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Emodin sensitizes the gemcitabine-resistant cell line Bxpc-3/Gem to gemcitabine via downregulation of NF-κB and its regulated targets

12 July 2018

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Inhibiting the interaction of cMET and IGF-1R with FAK effectively reduces growth of pancreatic cancer cells in vitro and in vivo

12 July 2018

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Targeting the hepatocyte growth factor-cMET axis in cancer therapy

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Met receptor tyrosine kinase signaling induces secretion of the angiogenic chemokine interleukin-8/CXCL8 in pancreatic cancer

12 July 2018

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Developments in metastatic pancreatic cancer: is gemcitabine still the standard?

12 July 2018

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Targeting MET in cancer: rationale and progress

12 July 2018

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HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast.

12 July 2018

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A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3.

12 July 2018

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Targeting FGFR/PDGFR/VEGFR impairs tumor growth, angiogenesis, and metastasis by effects on tumor cells, endothelial cells, and pericytes in pancreatic cancer.

12 July 2018

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FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer

12 July 2018

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Stromal biology and therapy in pancreatic cancer.

12 July 2018

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Modeling pancreatic cancer in vivo: from xenograft and carcinogen-induced systems to genetically engineered mice

12 July 2018

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Advanced pancreatic carcinoma: current treatment and future challenges

12 July 2018

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Targeting heat-shock protein 90 improves efficacy of rapamycin in a model of hepatocellular carcinoma in mice

12 July 2018

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Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes

12 July 2018

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MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival

12 July 2018

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Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces or

12 July 2018

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c-Met is essential for wound healing in the skin

12 July 2018

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Regulatory role of c-Met in insulin-like growth factor-I receptor-mediated migration and invasion of human pancreatic carcinoma cells

12 July 2018

1 reference

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Reversal of P-glycoprotein-mediated multidrug resistance in cancer cells by the c-Jun NH2-terminal kinase

12 July 2018

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p8 is a new target of gemcitabine in pancreatic cancer cells

12 July 2018

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Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair

12 July 2018

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A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo

12 July 2018

1 reference

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NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cells

12 July 2018

1 reference

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Activation of the urokinase plasminogen activator/urokinase plasminogen activator receptor system and redistribution of E-cadherin are associated with hepatocyte growth factor-induced motility of pancreas tumor cells overexpressing Met.

12 July 2018

1 reference

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Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

12 July 2018

1 reference

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HGF regulates VEGF expression via the c-Met receptor downstream pathways, PI3K/Akt, MAPK and STAT3, in CT26 murine cells

12 July 2018

1 reference

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Expression and prognostic significance of CD151, c-Met, and integrin alpha3/alpha6 in pancreatic ductal adenocarcinoma.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340491

Development and characterization of gemcitabine-resistant pancreatic tumor cells.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340491

Expression of the Multidrug-Resistance 1 (MDR1) Gene and Prognosis in Human Pancreatic Cancer

25 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2FS12885-015-1064-9

Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer

21 January 2018

1 reference

12 December 2020

The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling

1 reference

12 December 2020

c-Met is a marker of pancreatic cancer stem cells and therapeutic target

1 reference

12 December 2020

Postoperative Prognostic Predictors of Pancreatic Ductal Adenocarcinoma: Clinical Analysis and Immunoprofile on Tissue Microarrays

1 reference

12 December 2020

10.1186/S12885-015-1064-9

Identifiers

DOI

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Dimensions Publication ID

9 August 2017

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1 reference

9 August 2017

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