Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells. (Q35605717)

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scientific article published on 17 April 2015

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English	Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells.	scientific article published on 17 April 2015

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6 March 2020

Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells (English)

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6 March 2020

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6 March 2020

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Kai Jiang

1

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6 March 2020

Wei Wang

2

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6 March 2020

Xin Jin

3

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6 March 2020

Zhaoyang Wang

4

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6 March 2020

Zhiwei Ji

5

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6 March 2020

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17 April 2015

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6 March 2020

Oncology Reports

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6 March 2020

33

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6 March 2020

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6 March 2020

2711-2718

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6 March 2020

Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release

1 reference

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12 July 2018

Tetramethylpyrazine (TMP) protects against sodium arsenite-induced nephrotoxicity by suppressing ROS production, mitochondrial dysfunction, pro-inflammatory signaling pathways and programed cell death.

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12 July 2018

Silibinin induces apoptosis and inhibits proliferation of estrogen receptor (ER)-negative breast carcinoma cells through suppression of nuclear factor kappa B activation.

1 reference

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New therapeutic potentials of milk thistle (Silybum marianum).

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12 July 2018

Treating breast cancer in the 21st century: emerging biological therapies

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12 July 2018

Targeting cancer cell mitochondria as a therapeutic approach

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12 July 2018

Microcystin-LR induces cytoskeleton system reorganization through hyperphosphorylation of tau and HSP27 via PP2A inhibition and subsequent activation of the p38 MAPK signaling pathway in neuroendocrine (PC12) cells

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12 July 2018

Mitochondrial ROS generation for regulation of autophagic pathways in cancer

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12 July 2018

Silibinin induces apoptosis via calpain-dependent AIF nuclear translocation in U87MG human glioma cell death

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12 July 2018

Silibinin activated p53 and induced autophagic death in human fibrosarcoma HT1080 cells via reactive oxygen species-p38 and c-Jun N-terminal kinase pathways

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12 July 2018

Bnip3 as a dual regulator of mitochondrial turnover and cell death in the myocardium

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12 July 2018

Regulation of autophagy by ROS: physiology and pathology

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12 July 2018

Silibinin induced autophagic and apoptotic cell death in HT1080 cells through a reactive oxygen species pathway

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4431438

12 July 2018

Autophagy: cellular and molecular mechanisms

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12 July 2018

S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3

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12 July 2018

Silibinin suppresses TNF-alpha-induced MMP-9 expression in gastric cancer cells through inhibition of the MAPK pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4431438

12 July 2018

The role of Bcl-2 family member BNIP3 in cell death and disease: NIPping at the heels of cell death.

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12 July 2018

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

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12 July 2018

Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment

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12 July 2018

Apoptosis and autophagy: regulatory connections between two supposedly different processes

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12 July 2018

ROS, mitochondria and the regulation of autophagy

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12 July 2018

Autophagic and apoptotic response to stress signals in mammalian cells

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12 July 2018

Oxidative stress and autophagy

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12 July 2018

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

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12 July 2018

Autophagosomes: biogenesis from scratch?

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12 July 2018

LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

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Class III phosphoinositide 3-kinase--Beclin1 complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes.

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12 July 2018

Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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12 July 2018

BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore

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25 September 2018

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based on heuristic

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Silibinin induced-autophagic and apoptotic death is associated with an increase in reactive oxygen and nitrogen species in HeLa cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25891311

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.3892/OR.2015.3915

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6 March 2020

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6 March 2020

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