The mechanism of L-canavanine cytotoxicity: arginyl tRNA synthetase as a novel target for anticancer drug discovery (Q35614613)

9 August 2017

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title

The mechanism of L-canavanine cytotoxicity: arginyl tRNA synthetase as a novel target for anticancer drug discovery (English)

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9 August 2017

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Aimee K Bence

1

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PubMed ID

14692504

9 August 2017

Peter A Crooks

series ordinal

2

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PubMed ID

14692504

9 August 2017

language of work or name

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1 October 2003

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Journal of Enzyme Inhibition and Medicinal Chemistry

9 August 2017

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9 August 2017

18

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9 August 2017

5

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9 August 2017

383-394

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9 August 2017

Cancer statistics, 2003.

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

Gemcitabine-based combination treatment of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

Aminoacyl-tRNA synthetases: versatile players in the changing theater of translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

tRNA aminoacylation by arginyl-tRNA synthetase: induced conformations during substrates binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

Reaction pathway and rate-determining step in the aminoacylation of tRNAArg catalyzed by the arginyl-tRNA synthetase from yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

No arginyl adenylate is detectable as an intermediate in the aminoacylation of tRNAArg

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

L-arginine recognition by yeast arginyl-tRNA synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

The Biological Effects and Mode of Action of L-Canavanine, a Structural Analogue of L-Arginine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

An Ontogenetic Study of Canavanine Formation in the Fruit of Jack Bean, Canavalia ensiformis (L.) DC.

21 January 2018

1 reference

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Effect of amino acid analogs on the development of thermotolerance and on thermotolerant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

The biochemical basis for L-canavanine tolerance by the tobacco budworm Heliothis virescens (Noctuidae).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

Selective cytotoxicity of L-canavanine in tumorigenic Madin-Darby canine kidney T1 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

Growth inhibition of A549 human lung adenocarcinoma cells by L-canavanine is associated with p21/WAF1 induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

Middle T antigen-transformed endothelial cells exhibit an increased activity of nitric oxide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

L-Canavanine as a radiosensitization agent for human pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

Metabolism of L-[guanidinooxy-14C]canavanine in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

Immunocytochemical analysis of the transport of arginine analogues into nitrergic neurons and other cells in the retina and pituitary.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

The antiproliferative and immunotoxic effects of L-canavanine and L-canaline

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

Transport of L-arginine in cultured glial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

The biological and biochemical properties of L-canaline, a naturally occurring structural analogue of L-ornithine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

Current and future strategies for combined-modality therapy in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

Toxicity and pharmacokinetics of the nonprotein amino acid L-canavanine in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

A mutant Escherichia coli tyrosyl-tRNA synthetase utilizes the unnatural amino acid azatyrosine more efficiently than tyrosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

Azatyrosine. Mechanism of action for conversion of transformed phenotype to normal

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

Absolute requirement for transfer RNA in the activation of arginine by arginyl transfer RNA synthetase of yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

Arginyl-tRNA synthetase from Escherichia coli K12: specificity with regard to ATP analogs and their magnesium complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

Crystallization and preliminary X-ray crystallographic analysis of yeast arginyl-tRNA synthetase-yeast tRNAArg complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

The natural abundance of L-canavanine, an active anticancer agent, in alfalfa, medicago sativa (L.).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

Indospicine as an arginine antagonist in Escherichia coli and Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

Canavanine death in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

The effect of canavanine on protein synthesis and protein degradation in IMR-90 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

L-Canavanine modulates cellular growth, chemosensitivity and P-glycoprotein substrate accumulation in cultured human tumor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells

21 January 2018

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https://api.crossref.org/works/10.1080%2F1475636031000152277

X-ray sensitivity and DNA synthesis in synchronous populations of HeLa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

Modulation of human platelet function by L-canavanine: differential effects of low and high concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

Structure-activity studies of L-canaline-mediated inhibition of porcine alanine aminotransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

Growth inhibitory effect of L-canavanine against MIA PaCa-2 pancreatic cancer cells is not due to conversion to its toxic metabolite canaline.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1475636031000152277

Combination therapy with 5-fluorouracil and L-canavanine: in vitro and in vivo studies

21 January 2018

1 reference

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10.1080/1475636031000152277

21 January 2018

Identifiers

DOI

1 reference

9 August 2017

1 reference

PubMed ID

14692504