Rediscovering the sweet spot in drug discovery. (Q35615371)

9 August 2017

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title

Rediscovering the sweet spot in drug discovery. (English)

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9 August 2017

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2

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9 August 2017

David Brown

1

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9 August 2017

1 December 2003

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9 August 2017

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9 August 2017

8

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9 August 2017

23

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9 August 2017

1067-1077

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Drug discovery: a historical perspective

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Stategic trends in the drug industry

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The emergence of the drug receptor theory

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The Sequence of the Human Genome

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Initial sequencing and analysis of the human genome

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A new paradigm for drug discovery: integrating clinical, genetic, genomic and molecular phenotype data to identify drug targets

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Fulfilling the promise: drug discovery in the post-genomic era.

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Assembly of Cell Regulatory Systems Through Protein Interaction Domains

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Integrated genomic and proteomic analyses of a systematically perturbed metabolic network

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Signal transduction as a drug-discovery platform

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Global approaches to protein-protein interactions

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A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling

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A Growing Network of Cancer-Susceptibility Genes

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Evolution of enzyme cascades from embryonic development to blood coagulation

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New drug targets for type 2 diabetes and the metabolic syndrome

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Mitochondrial respiratory-chain diseases

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Proteomics: quantitative and physical mapping of cellular proteins

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Mass spectrometry-based proteomics

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AU binding proteins recruit the exosome to degrade ARE-containing mRNAs

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Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis

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7 January 2021

Targeting signal transduction with large combinatorial collections

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Chemogenomic approaches to drug discovery

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A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

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Quantitative chemical proteomics for identifying candidate drug targets

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Discovery of novel targets of quinoline drugs in the human purine binding proteome

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Synthetic small molecules that control stem cell fate

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Discovering potent and selective reversible inhibitors of enzymes in complex proteomes

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Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.

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A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p

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In the pursuit of industrial proteomics

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7 January 2021

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Identifiers

DOI

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9 August 2017

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PubMed ID

14693466