Human uncoupling protein-3 and obesity: an update (Q35615645)

9 August 2017

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title

Human uncoupling protein-3 and obesity: an update (English)

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9 August 2017

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3

Patrick Schrauwen

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Matthijs Hesselink

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1

object named as

Matthijs K C Hesselink

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Marco Mensink

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2

object named as

Marco Mensink

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9 August 2017

1 December 2003

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9 August 2017

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9 August 2017

11

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9 August 2017

12

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9 August 2017

1429-1443

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Chemiosmotic hypothesis of oxidative phosphorylation

9 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

The Identification of the Component in the Inner Membrane of Brown Adipose Tissue Mitochondria Responsible for Regulating Energy Dissipation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

UCP1: the original uncoupling protein--and perhaps the only one? New perspectives on UCP1, UCP2, and UCP3 in the light of the bioenergetics of the UCP1-ablated mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Mitochondrial proton leak and the uncoupling protein 1 homologues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

A mitochondrial uncoupling artifact can be caused by expression of uncoupling protein 1 in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Superoxide activates mitochondrial uncoupling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

The effect of weight reduction on skeletal muscle UCP2 and UCP3 mRNA expression and UCP3 protein content in Type II diabetic subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Energy metabolism in uncoupling protein 3 gene knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Reconstitution of recombinant uncoupling proteins: UCP1, -2, and -3 have similar affinities for ATP and are unaffected by coenzyme Q10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

In vivo effects of uncoupling protein-3 gene disruption on mitochondrial energy metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Reduced rate of energy expenditure as a risk factor for body-weight gain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Skeletal muscle uncoupling protein 3 expression is a determinant of energy expenditure in Pima Indians.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Assessment of mitochondrial energy coupling in vivo by 13C/31P NMR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

13C/31P NMR assessment of mitochondrial energy coupling in skeletal muscle of awake fed and fasted rats. Relationship with uncoupling protein 3 expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Evidence that single nucleotide polymorphism in the uncoupling protein 3 (UCP3) gene influences fat distribution in women of European and Asian origin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

A novel polymorphism in the proximal UCP3 promoter region: effect on skeletal muscle UCP3 mRNA expression and obesity in male non-diabetic Pima Indians

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

An uncoupling protein 3 gene polymorphism associated with a lower risk of developing Type II diabetes and with atherogenic lipid profile in a French cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Organisation of the coding exons and mutational screening of the uncoupling protein 3 gene in subjects with juvenile-onset obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Beta 3-adrenergic agonist up-regulates uncoupling proteins 2 and 3 in skeletal muscle of the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Up-regulation of uncoupling proteins by beta-adrenergic stimulation in L6 myotubes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Effect of beta1- and beta2-adrenergic stimulation on energy expenditure, substrate oxidation, and UCP3 expression in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Elevated free fatty acids induce uncoupling protein 3 expression in muscle: a potential explanation for the effect of fasting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Up-regulation of uncoupling protein-3 by fatty acid in C2C12 myotubes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Uncoupling protein-3 gene expression in skeletal muscle during development is regulated by nutritional factors that alter circulating non-esterified fatty acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Post-starvation gene expression of skeletal muscle uncoupling protein 2 and uncoupling protein 3 in response to dietary fat levels and fatty acid composition: a link with insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Fiber type dependent upregulation of human skeletal muscle UCP2 and UCP3 mRNA expression by high-fat diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Skeletal muscle UCP2 and UCP3 expression in trained and untrained male subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

UCP3 protein expression is lower in type I, IIa and IIx muscle fiber types of endurance-trained compared to untrained subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

An alternative function for human uncoupling protein 3: protection of mitochondria against accumulation of nonesterified fatty acids inside the mitochondrial matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Decreased mechanical efficiency in clinically stable patients with COPD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Uncoupling protein-3 content is decreased in peripheral skeletal muscle of patients with COPD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Interorgan signaling between adipose tissue metabolism and skeletal muscle uncoupling protein homologs: is there a role for circulating free fatty acids?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Increase in fat oxidation on a high-fat diet is accompanied by an increase in triglyceride-derived fatty acid oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Decreased uncoupling protein expression and intramyocytic triglyceride depletion in formerly obese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Fatty acid cycling mechanism and mitochondrial uncoupling proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Anion carriers in fatty acid-mediated physiological uncoupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Concordant mRNA expression of UCP-3, but not UCP-2, with mitochondrial thioesterase-1 in brown adipose tissue and skeletal muscle in db/db diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

De novo expression of uncoupling protein 3 is associated to enhanced mitochondrial thioesterase-1 expression and fatty acid metabolism in liver of fenofibrate-treated rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Cloning and characterization of the 5' flanking region of the human uncoupling protein 3 (UCP3) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Regulation of the uncoupling protein gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Decreased fatty acid beta-oxidation in riboflavin-responsive, multiple acylcoenzyme A dehydrogenase-deficient patients is associated with an increase in uncoupling protein-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Regulation of UCP2 and UCP3 by muscle disuse and physical activity in tetraplegic subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Contribution of mitochondrial proton leak to skeletal muscle respiration and to standard metabolic rate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Contribution of mitochondrial proton leak to respiration rate in working skeletal muscle and liver and to SMR

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Assessment of uncoupling activity of uncoupling protein 3 using a yeast heterologous expression system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Recombinant human uncoupling protein-3 increases thermogenesis in yeast cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Properties of the human long and short isoforms of the uncoupling protein-3 expressed in yeast cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

UCP3 expressed in yeast is primarily localized in extramitochondrial particles

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Protein expression of UCP3 differs between human type 1, type 2a, and type 2b fibers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Altered relationship between protonmotive force and respiration rate in non-phosphorylating liver mitochondria isolated from rats of different thyroid hormone status

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Expression of uncoupling protein-3 and mitochondrial activity in the transition from hypothyroid to hyperthyroid state in rat skeletal muscle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

A genetic variation in the 5' flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Leptin, but not a β3-adrenergic agonist, upregulates muscle uncoupling protein-3 messenger RNA expression: short-term thermogenic interactions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Activators of peroxisome proliferator-activated receptor-alpha induce the expression of the uncoupling protein-3 gene in skeletal muscle: a potential mechanism for the lipid intake-dependent activation of uncoupling protein-3 gene expression at birth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

High-fat diet feeding elevates skeletal muscle uncoupling protein 3 levels but not its activity in rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

A short-term, high-fat diet up-regulates lipid metabolism and gene expression in human skeletal muscle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

UCP-3 expression in skeletal muscle: effects of exercise, hypoxia, and AMP-activated protein kinase.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Effect of acute exercise on uncoupling protein 3 is a fat metabolism-mediated effect

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Exercise attenuates the fasting-induced transcriptional activation of metabolic genes in skeletal muscle.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Streptozotocin treatment upregulates uncoupling protein 3 expression in the rat heart

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Tissue-specific expression of the uncoupling protein family in streptozotocin-induced diabetic rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Overexpression of UCP-3 in Skeletal Muscle of Mice Results in Increased Expression of Mitochondrial Thioesterase mRNA

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Etomoxir-induced increase in UCP3 supports a role of uncoupling protein 3 as a mitochondrial fatty acid anion exporter

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

Effect of endurance training on mRNA expression of uncoupling proteins 1, 2, and 3 in the rat.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

inferred from DOI database lookup

7 January 2021

based on heuristic

Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate?

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

inferred from DOI database lookup

7 January 2021

based on heuristic

Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.192

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/OBY.2003.192

1 reference

9 August 2017

1 reference

PubMed ID

14694206