iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling (Q35616369)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25918388%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling (English)

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6 March 2020

6

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6 March 2020

author name string

Xue Li

1

1 reference

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6 March 2020

Thorsten Maretzky

2

1 reference

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6 March 2020

Gisela Weskamp

3

1 reference

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6 March 2020

Sébastien Monette

4

1 reference

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6 March 2020

Xiaoping Qing

5

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6 March 2020

Howard C Crawford

7

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6 March 2020

David R McIlwain

8

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6 March 2020

Tak W Mak

9

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6 March 2020

Jane E Salmon

10

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6 March 2020

Carl P Blobel

11

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6 March 2020

language of work or name

English

0 references

publication date

27 April 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25918388%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

6 March 2020

published in

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6 March 2020

volume

112

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6 March 2020

issue

19

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6 March 2020

page(s)

6080-6085

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25918388%20AND%20SRC:MED&resulttype=core&format=json

TACE/ADAM17 is essential for oligodendrocyte development and CNS myelination

6 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

Epithelial inflammation resulting from an inherited loss-of-function mutation in EGFR

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

iRHOM2 is a critical pathogenic mediator of inflammatory arthritis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

iRhom2 is required for the secretion of mouse TNFα

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

The role of protease activity in ErbB biology

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

Mechanisms of cutaneous toxicities to EGFR inhibitors.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

ADAM17 deficiency by mature neutrophils has differential effects on L-selectin shedding

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

ADAMs: key components in EGFR signalling and development

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

EGFR signal transactivation in cancer cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

Epidermal EGFR controls cutaneous host defense and prevents inflammation

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

Inflammatory skin and bowel disease linked to ADAM17 deletion

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4434755

Strain-dependent epithelial defects in mice lacking the EGF receptor

25 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1505649112

An essential role for ectodomain shedding in mammalian development

21 January 2018

1 reference

12 December 2020

HB-EGF promotes epithelial cell migration in eyelid development

1 reference

12 December 2020

Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock

1 reference

12 December 2020

Cell biology. Sheddase gets guidance

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1505649112

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25918388%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25918388%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

PubMed publication ID

25918388

1 reference