Elimination of insulitis and augmentation of islet beta cell regeneration via induction of chimerism in overtly diabetic NOD mice (Q35616760)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17267595%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

title

Elimination of insulitis and augmentation of islet beta cell regeneration via induction of chimerism in overtly diabetic NOD mice (English)

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25 December 2019

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3

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25 December 2019

author name string

Chunyan Zhang

1

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25 December 2019

Ivan Todorov

2

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25 December 2019

Mark Atkinson

4

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25 December 2019

Fouad Kandeel

5

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25 December 2019

Stephen Forman

6

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25 December 2019

Defu Zeng

7

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25 December 2019

language of work or name

English

0 references

publication date

31 January 2007

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Proceedings of the National Academy of Sciences of the United States of America

25 December 2019

published in

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25 December 2019

volume

104

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25 December 2019

issue

7

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25 December 2019

page(s)

2337-2342

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Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs

25 December 2019

cites work

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Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells.

12 July 2018

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Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution

12 July 2018

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Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration

12 July 2018

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TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs

12 July 2018

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Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes

12 July 2018

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12 July 2018

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A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes

12 July 2018

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Opinion: Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes

12 July 2018

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Epithelial-to-Mesenchymal Transition Generates Proliferative Human Islet Precursor Cells

12 July 2018

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Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

12 July 2018

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Islet Regeneration During the Reversal of Autoimmune Diabetes in NOD Mice

12 July 2018

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Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning

12 July 2018

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Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala).

12 July 2018

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Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

12 July 2018

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The insulin gene in diabetes

12 July 2018

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Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants

12 July 2018

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A defect in interleukin 12-induced activation and interferon gamma secretion of peripheral natural killer T cells in nonobese diabetic mice suggests new pathogenic mechanisms for insulin-dependent diabetes mellitus.

12 July 2018

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Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice

12 July 2018

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Discordance of exocrine and endocrine growth after 90% pancreatectomy in rats

12 July 2018

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12 July 2018

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12 July 2018

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ADA Outstanding Scientific Achievement Lecture 2004. Thirty years of investigating the autoimmune basis for type 1 diabetes: why can't we prevent or reverse this disease?

21 January 2018

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TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes.

21 January 2018

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Mixed hematopoietic chimerism allows cure of autoimmune diabetes through allogeneic tolerance and reversal of autoimmunity.

21 January 2018

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Donor CD8+ T cells facilitate induction of chimerism and tolerance without GVHD in autoimmune NOD mice conditioned with anti-CD3 mAb.

21 January 2018

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Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4.

21 January 2018

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Bone marrow-derived stem cells initiate pancreatic regeneration.

21 January 2018

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Increased vulnerability of newly forming beta cells to cytokine-induced cell death.

21 January 2018

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NOD mice have a generalized defect in their response to transplantation tolerance induction.

21 January 2018

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Donor CD8+ T cells mediate graft-versus-leukemia activity without clinical signs of graft-versus-host disease in recipients conditioned with anti-CD3 monoclonal antibody.

21 January 2018

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Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/L

21 January 2018

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Mixed allogeneic chimerism induced by a sublethal approach prevents autoimmune diabetes and reverses insulitis in nonobese diabetic (NOD) mice.

25 September 2018

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Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea

25 September 2018

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Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment

25 September 2018

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A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development

25 September 2018

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12 December 2020

CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice

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12 December 2020

Preconditioning of NOD mice with anti-CD8 mAb and costimulatory blockade enhances chimerism and tolerance and prevents diabetes, while depletion of alpha beta-TCR+ and CD4+ cells negates the effect

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12 December 2020

Defective central tolerance induction in NOD mice: genomics and genetics

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12 December 2020

Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes

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12 December 2020

Pancreatic regeneration in type 1 diabetes: dreams on a deserted islet?

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12 December 2020

Purified allogeneic hematopoietic stem cell transplantation blocks diabetes pathogenesis in NOD mice

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0611101104

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17267595%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

0 references

1 reference

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25 December 2019

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