The GGA proteins: adaptors on the move (Q35621350)

9 August 2017

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title

The GGA proteins: adaptors on the move (English)

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9 August 2017

Juan S Bonifacino

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9 August 2017

1 January 2004

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Nature Reviews Molecular Cell Biology

9 August 2017

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9 August 2017

5

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9 August 2017

23-32

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9 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/nrm1279

9 August 2017

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cites work

Three ways to make a vesicle

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Coat proteins: shaping membrane transport

31 March 2020

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Accessory factors in clathrin-dependent synaptic vesicle endocytosis

31 March 2020

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Signals for sorting of transmembrane proteins to endosomes and lysosomes

31 March 2020

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Association of the AP-3 adaptor complex with clathrin

31 March 2020

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Assembly and function of AP-3 complexes in cells expressing mutant subunits.

31 March 2020

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A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi

31 March 2020

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GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex

31 March 2020

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A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome

31 March 2020

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Vear, a novel Golgi-associated protein with VHS and gamma-adaptin "ear" domains

31 March 2020

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The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

31 March 2020

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Sorting of mannose 6-phosphate receptors mediated by the GGAs

31 March 2020

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Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor

31 March 2020

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Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains

31 March 2020

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Mannose 6-phosphate receptors: new twists in the tale

31 March 2020

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The cytoplasmic tail of the mannose 6-phosphate/insulin-like growth factor-II receptor has two signals for lysosomal enzyme sorting in the Golgi

31 March 2020

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Systematic mutational analysis of the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor cytoplasmic domain. An acidic cluster containing a key aspartate is important for function in lysosomal enzyme sorting

31 March 2020

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Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins

31 March 2020

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Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif

31 March 2020

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Phosphorylation-induced conformational changes regulate GGAs 1 and 3 function at the trans-Golgi network

31 March 2020

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Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network

31 March 2020

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Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains

31 March 2020

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Structural basis for recognition of acidic-cluster dileucine sequence by GGA1

31 March 2020

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Crystal structure of GGA2 VHS domain and its implication in plasticity in the ligand binding pocket

31 March 2020

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Structure of the VHS domain of human Tom1 (target of myb 1): insights into interactions with proteins and membranes

31 March 2020

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Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction

31 March 2020

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Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZ

31 March 2020

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Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes

31 March 2020

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Regulators and effectors of the ARF GTPases.

31 March 2020

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The GGAs promote ARF-dependent recruitment of clathrin to the TGN

31 March 2020

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ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization

31 March 2020

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GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors

31 March 2020

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Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex

31 March 2020

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Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex

31 March 2020

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The structure of the GGA1-GAT domain reveals the molecular basis for ARF binding and membrane association of GGAs

31 March 2020

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Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport

31 March 2020

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Structure of the GAT domain of human GGA1: A syntaxin amino-terminal domain fold in an endosomal trafficking adaptor

31 March 2020

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Crystal structure of the human GGA1 GAT domain

31 March 2020

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Structural Basis for Activation of ARF GTPase

31 March 2020

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Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis

31 March 2020

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Structure of the guanine nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase

31 March 2020

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Arf1 dissociates from the clathrin adaptor GGA prior to being inactivated by Arf GTPase-activating proteins

31 March 2020

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Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A

31 March 2020

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Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin

31 March 2020

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Yeast Gga coat proteins function with clathrin in Golgi to endosome transport

31 March 2020

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Structural requirements for function of yeast GGAs in vacuolar protein sorting, alpha-factor maturation, and interactions with clathrin.

31 March 2020

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Morphology and dynamics of clathrin/GGA1-coated carriers budding from the trans-Golgi network

31 March 2020

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GGAs: roles of the different domains and comparison with AP-1 and clathrin

31 March 2020

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Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin

31 March 2020

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Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin

31 March 2020

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Gamma subunit of the AP-1 adaptor complex binds clathrin: implications for cooperative binding in coated vesicle assembly

31 March 2020

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Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain.

31 March 2020

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Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics

31 March 2020

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EpsinR: an ENTH domain-containing protein that interacts with AP-1.

31 March 2020

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EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking

31 March 2020

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Clint: a novel clathrin-binding ENTH-domain protein at the Golgi

31 March 2020

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31 March 2020

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Curvature of clathrin-coated pits driven by epsin

31 March 2020

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Structural basis for binding of accessory proteins by the appendage domain of GGAs

31 March 2020

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Recognition of accessory protein motifs by the gamma-adaptin ear domain of GGA3

31 March 2020

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γ-Adaptin Appendage Domain

31 March 2020

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Arf regulates interaction of GGA with mannose-6-phosphate receptor

31 March 2020

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Trafficking of yellow-fluorescent-protein-tagged mu1 subunit of clathrin adaptor AP-1 complex in living cells

31 March 2020

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Visualization of TGN to endosome trafficking through fluorescently labeled MPR and AP-1 in living cells

31 March 2020

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A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex

31 March 2020

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Yeast GGA proteins interact with GTP-bound Arf and facilitate transport through the Golgi

31 March 2020

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The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene

31 March 2020

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Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting

31 March 2020

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A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodies

31 March 2020

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A selective transport route from Golgi to late endosomes that requires the yeast GGA proteins

31 March 2020

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Molecules in the ARF orbit.

31 March 2020

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Unusual structural organization of the endocytic proteins AP180 and epsin 1

31 March 2020

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A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

31 March 2020

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The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery

31 March 2020

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ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2

31 March 2020

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Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2

31 March 2020

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Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor

31 March 2020

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Accessory protein recruitment motifs in clathrin-mediated endocytosis

31 March 2020

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The actin-binding protein Hip1R associates with clathrin during early stages of endocytosis and promotes clathrin assembly in vitro

31 March 2020

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Numb is an endocytic protein

31 March 2020

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Hrs recruits clathrin to early endosomes

31 March 2020

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STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes

31 March 2020

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The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding

31 March 2020

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Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1279

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9 August 2017

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PubMed ID

14708007