The elusive role of the prion protein and the mechanism of toxicity in prion disease. (Q35624321)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25951168%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

review article

1 reference

title

The elusive role of the prion protein and the mechanism of toxicity in prion disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25951168%20AND%20SRC:MED&resulttype=core&format=json

transmissible spongiform encephalopathy

7 March 2020

main subject

prion protein family

0 references

3 references

23 March 2019

25 April 2019

21 December 2019

proteostasis deficiency

3 references

23 March 2019

25 April 2019

21 December 2019

1 reference

21 December 2019

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25951168%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

author name string

Roberto Chiesa

series ordinal

1

1 reference

PubMed ID

25951168

9 August 2017

language of work or name

1 reference

7 May 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25951168%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

4 references

23 March 2019

25 April 2019

21 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25951168%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

volume

11

1 reference

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7 March 2020

issue

5

1 reference

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7 March 2020

page(s)

e1004745

1 reference

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Creative Commons Attribution 4.0 International

7 March 2020

copyright license

3 references

23 March 2019

25 April 2019

on focus list of Wikimedia project

21 December 2019

copyright status

copyrighted

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ScienceSource

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cites work

Transgenic fatal familial insomnia mice indicate prion infectivity-independent mechanisms of pathogenesis and phenotypic expression of disease

1 reference

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Variably protease-sensitive prionopathy, a unique prion variant with inefficient transmission properties

27 July 2018

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Synaptic dysfunction in prion diseases: a trafficking problem?

27 July 2018

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A novel prion disease associated with diarrhea and autonomic neuropathy

27 July 2018

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A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity

27 July 2018

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Sustained translational repression by eIF2α-P mediates prion neurodegeneration

27 July 2018

1 reference

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Mutant PrP suppresses glutamatergic neurotransmission in cerebellar granule neurons by impairing membrane delivery of VGCC α(2)δ-1 Subunit

27 July 2018

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Expression of mutant or cytosolic PrP in transgenic mice and cells is not associated with endoplasmic reticulum stress or proteasome dysfunction

27 July 2018

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The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

27 July 2018

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Fatal transmissible amyloid encephalopathy: a new type of prion disease associated with lack of prion protein membrane anchoring

27 July 2018

1 reference

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Fishing for prion protein function

27 July 2018

1 reference

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Regulation of embryonic cell adhesion by the prion protein

27 July 2018

1 reference

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The prion protein knockout mouse: a phenotype under challenge

27 July 2018

1 reference

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Prion protein attenuates excitotoxicity by inhibiting NMDA receptors

27 July 2018

1 reference

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Physiology of the prion protein

27 July 2018

1 reference

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Lethal recessive myelin toxicity of prion protein lacking its central domain

27 July 2018

1 reference

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Anchorless prion protein results in infectious amyloid disease without clinical scrapie

27 July 2018

1 reference

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Transmissible and genetic prion diseases share a common pathway of neurodegeneration

27 July 2018

1 reference

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Mice devoid of PrP are resistant to scrapie

27 July 2018

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Cytoprotective effect of NMDA receptor antagonists on prion protein (PrionSc)-induced toxicity in rat cortical cell cultures.

27 July 2018

1 reference

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Inherited prion diseases and transmission to rodents

27 July 2018

1 reference

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Drug resistance confounding prion therapeutics

27 July 2018

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The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein

25 September 2018

1 reference

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An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity

25 September 2018

1 reference

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Darwinian evolution of prions in cell culture

25 September 2018

1 reference

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Mutant prion protein expression causes motor and memory deficits and abnormal sleep patterns in a transgenic mouse model.

25 September 2018

1 reference

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Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125.

25 September 2018

1 reference

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Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

25 September 2018

1 reference

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Neurological illness in transgenic mice expressing a prion protein with an insertional mutation.

25 September 2018

1 reference

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Normal host prion protein necessary for scrapie-induced neurotoxicity.

25 September 2018

1 reference

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10.1371/JOURNAL.PPAT.1004745

25 September 2018

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25951168%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25951168%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25951168%20AND%20SRC:MED&resulttype=core&format=json