2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) is enantioselectively oxidized to hydroxylated metabolites by rat liver microsomes (Q35626926)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22026639%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) is enantioselectively oxidized to hydroxylated metabolites by rat liver microsomes (English)

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15 January 2020

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3

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15 January 2020

Hans-Joachim Lehmler

6

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15 January 2020

author name string

Xianai Wu

1

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15 January 2020

Ananya Pramanik

2

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15 January 2020

Eugene G Hrycay

4

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15 January 2020

Stelvio M Bandiera

5

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15 January 2020

Izabela Kania-Korwel

7

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publication date

10 November 2011

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Chemical Research in Toxicology

15 January 2020

published in

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volume

24

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issue

12

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15 January 2020

page(s)

2249-2257

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Applications of polychlorinated biphenyls

15 January 2020

cites work

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Clearance of polychlorinated biphenyl atropisomers is enantioselective in female C57Bl/6 mice

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Chiral polychlorinated biphenyl transport, metabolism, and distribution: a review.

12 July 2018

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Simultaneous extraction and clean-up of polychlorinated biphenyls and their metabolites from small tissue samples using pressurized liquid extraction

12 July 2018

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Enantiomeric specificity of (-)-2,2',3,3',6,6'-hexachlorobiphenyl toward ryanodine receptor types 1 and 2

12 July 2018

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Gas chromatographic separation of methoxylated polychlorinated biphenyl atropisomers

12 July 2018

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2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) atropisomers interact enantioselectively with hepatic microsomal cytochrome P450 enzymes

12 July 2018

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Neurochemical targets and behavioral effects of organohalogen compounds: an update

12 July 2018

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Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1).

12 July 2018

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Fetal exposure to PCBs and their hydroxylated metabolites in a Dutch cohort

12 July 2018

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Protein measurement with the Folin phenol reagent

12 July 2018

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Human prenatal and postnatal exposure to polybrominated diphenyl ethers, polychlorinated biphenyls, polychlorobiphenylols, and pentachlorophenol

12 July 2018

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Effects of PCB exposure on neuropsychological function in children

12 July 2018

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Evaluation of 7-benzyloxy-4-trifluoromethylcoumarin, some other 7-hydroxy-4-trifluoromethylcoumarin derivatives and 7-benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome P450 enzymes

12 July 2018

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Ortho-substituted polychlorinated biphenyls alter calcium regulation by a ryanodine receptor-mediated mechanism: structural specificity toward skeletal- and cardiac-type microsomal calcium release channels.

12 July 2018

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Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl and 2,2',4,4',5,5'-hexachlorobiphenyl by human hepatic microsomes

12 July 2018

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Changes in serum concentrations of polychlorinated biphenyls (PCBs), hydroxylated PCB metabolites and pentachlorophenol during pregnancy

12 July 2018

1 reference

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Polychlorinated biphenyls and their hydroxylated metabolites (OH-PCBs) in the blood of toothed and baleen whales stranded along Japanese coastal waters.

25 September 2018

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Distribution of PCBs, their hydroxylated metabolites, and other phenolic contaminants in human serum from two European countries.

25 September 2018

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Chiral polychlorinated biphenyls are biotransformed enantioselectively by mammalian cytochrome P-450 isozymes to form hydroxylated metabolites.

25 September 2018

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Hydroxylated polychlorinated biphenyls (OH-PCBs) in the blood of mammals and birds from Japan: lower chlorinated OH-PCBs and profiles

25 September 2018

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Enantioselective disposition of PCB 136 (2,2',3,3',6,6'-hexachlorobiphenyl) in C57BL/6 mice after oral and intraperitoneal administration.

25 September 2018

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Congener-specific tissue distribution of aroclor 1254 and a highly chlorinated environmental PCB mixture in rats

25 September 2018

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Chiral PCB methyl sulfones in rat tissues after exposure to technical PCBs

25 September 2018

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Ortho-substituted 2,2',3,5',6-pentachlorobiphenyl (PCB 95) alters rat hippocampal ryanodine receptors and neuroplasticity in vitro: evidence for altered hippocampal function

25 September 2018

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Ortho-substituted polychlorinated biphenyls alter microsomal calcium transport by direct interaction with ryanodine receptors of mammalian brain

25 September 2018

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A simple method for detecting steroid aggregation and estimating solubility in aqueous solutions

25 September 2018

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12 December 2020

Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochromes P-450c and P-450d, by structurally diverse xenobiotics

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12 December 2020

Non-arene oxide aromatic ring hydroxylation of 2,2',5,5'-tetrachlorobiphenyl as the major metabolic pathway catalyzed by phenobarbital-induced rat liver microsomes

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12 December 2020

A microassay for the detection of low levels of cytochrome P450 O-deethylation activities with alkoxyresorufin substrates

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12 December 2020

2,2',3,3',6,6'-hexachlorobiphenyl hydroxylation by active site mutants of cytochrome P450 2B1 and 2B11

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12 December 2020

Biotransformation of polychlorinated biphenyls (PCBs) and bioformation of hydroxylated PCBs in fish

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12 December 2020

Enantioselective formation of methyl sulfone metabolites of 2,2',3,3',4,6'-hexachlorobiphenyl in rat

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12 December 2020

Identifiers

DOI

10.1021/TX200360M

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22026639%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

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15 January 2020

PubMed publication ID

22026639

1 reference