Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease (Q35631319)

9 August 2017

title

Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease (English)

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9 August 2017

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14

H Leighton Grimes

1 reference

9 August 2017

Sonia D'Souza

1

1 reference

9 August 2017

Davide del Prete

2

1 reference

9 August 2017

Shunqian Jin

3

1 reference

9 August 2017

Quanhong Sun

4

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9 August 2017

Alissa J Huston

5

1 reference

9 August 2017

Flavia Esteve Kostov

6

1 reference

9 August 2017

Benedicte Sammut

7

1 reference

9 August 2017

Chang-Sook Hong

8

1 reference

9 August 2017

Judith L Anderson

9

1 reference

9 August 2017

Kenneth D Patrene

10

1 reference

9 August 2017

Shibing Yu

11

1 reference

9 August 2017

Chinavenmeni S Velu

12

1 reference

9 August 2017

Guozhi Xiao

13

1 reference

9 August 2017

G David Roodman

15

1 reference

9 August 2017

Deborah L Galson

16

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9 August 2017

language of work or name

English

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publication date

31 October 2011

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9 August 2017

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9 August 2017

volume

118

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9 August 2017

issue

26

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9 August 2017

page(s)

6871-6880

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IMiD immunomodulatory compounds block C/EBP{beta} translation through eIF4E down-regulation resulting in inhibition of MM.

9 August 2017

cites work

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A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia

27 July 2018

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Gfi1 integrates progenitor versus granulocytic transcriptional programming

27 July 2018

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Increased signaling through p62 in the marrow microenvironment increases myeloma cell growth and osteoclast formation

27 July 2018

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Gfi1 regulates miR-21 and miR-196b to control myelopoiesis

27 July 2018

1 reference

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Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1.

27 July 2018

1 reference

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Negative regulation of the osteoblast function in multiple myeloma through the repressor gene E4BP4 activated by malignant plasma cells.

27 July 2018

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Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor

27 July 2018

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Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1.

27 July 2018

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Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma

27 July 2018

1 reference

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Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1

27 July 2018

1 reference

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Production of Wnt inhibitors by myeloma cells: potential effects on canonical Wnt pathway in the bone microenvironment.

27 July 2018

1 reference

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Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Epigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5

27 July 2018

1 reference

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Cooperative interaction between ETS1 and GFI1 transcription factors in the repression of Bax gene expression

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Multiple myeloma bone disease: Pathophysiology of osteoblast inhibition.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Transcriptional regulation of the osterix (Osx, Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NF kappa B pathways

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

IL-3 is a potential inhibitor of osteoblast differentiation in multiple myeloma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Minireview: transcriptional regulation in development of bone

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Anti-alpha4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome

27 July 2018

1 reference

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The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism

27 July 2018

1 reference

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Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2

27 July 2018

1 reference

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Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency

27 July 2018

1 reference

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Characterization of an osteoblast-specific enhancer element in the CBFA1 gene

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Generation of fusion genes carrying drug resistance, green fluorescent protein, and herpes simplex virus thymidine kinase genes in a single cistron

27 July 2018

1 reference

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The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene

27 July 2018

1 reference

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A murine model of human myeloma bone disease

27 July 2018

1 reference

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The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Elevated tumor necrosis factor-alpha suppresses TAZ expression and impairs osteogenic potential of Flk-1+ mesenchymal stem cells in patients with multiple myeloma.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

TNF-alpha inhibits BMP-induced osteoblast differentiation through activating SAPK/JNK signaling

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Mechanisms of bone metastasis

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Dual effects of macrophage inflammatory protein-1alpha on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Isolation and characterization of MC3T3-E1 preosteoblast subclones with distinct in vitro and in vivo differentiation/mineralization potential

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Role of the alpha2-integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Follow-up of bone lesions in an experimental multiple myeloma mouse model: description of an in vivo technique using radiography dedicated for mammography

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245209

Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22042697

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Ascorbic acid-dependent activation of the osteocalcin promoter in MC3T3-E1 preosteoblasts: requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22042697

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2011-04-346775

1 reference

release_ib2yhu7qpbcrrk76vpfbiw4fry

9 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ib2yhu7qpbcrrk76vpfbiw4fry

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

3245209

1 reference

9 August 2017

1 reference