Molecular genetic alterations in adrenal and extra-adrenal pheochromocytomas and paragangliomas (Q35636300)

9 August 2017

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title

Molecular genetic alterations in adrenal and extra-adrenal pheochromocytomas and paragangliomas (English)

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9 August 2017

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5

Ronald R de Krijger

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9 August 2017

3

Winand N M Dinjens

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9 August 2017

1

Hilde Dannenberg

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9 August 2017

Paul Komminoth

2

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9 August 2017

Ernst Jan M Speel

series ordinal

4

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9 August 2017

publication date

1 January 2003

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9 August 2017

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9 August 2017

volume

14

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9 August 2017

issue

4

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9 August 2017

page(s)

329-350

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Expression of angiogenic growth factors in paragangliomas

9 August 2017

cites work

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12 December 2020

Pheochromocytoma in Italy: a multicentric retrospective study

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12 December 2020

Selective loss of chromosome 11 in pheochromocytomas associated with the VHL syndrome

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12 December 2020

Expression of HER-2/neu receptor protein in adrenal tumors

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12 December 2020

Expression of the ret proto-oncogene in phaeochromocytoma. An in situ hybridization and northern blot study

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12 December 2020

Extensive mutation scanning of RET in sporadic medullary thyroid carcinoma and of RET and VHL in sporadic pheochromocytoma reveals involvement of these genes in only a minority of cases.

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12 December 2020

High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays

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12 December 2020

Concurrence of carotid body tumor and pheochromocytoma

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12 December 2020

Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporadic phaeochromocytomas

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12 December 2020

N-cadherin expression in adrenal tumors: upregulation in malignant pheochromocytoma and downregulation in adrenocortical carcinoma

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12 December 2020

Loss of heterozygosity on the long arm of chromosome 22 in pheochromocytoma

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12 December 2020

Frequent germ-line succinate dehydrogenase subunit D gene mutations in patients with apparently sporadic parasympathetic paraganglioma.

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12 December 2020

Hereditary phaeochromocytomas and paragangliomas: a study of five susceptibility genes

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12 December 2020

The value of plasma markers for the clinical behaviour of phaeochromocytomas

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12 December 2020

p53 protein and its messenger ribonucleic acid in human adrenal tumors

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12 December 2020

Expression pattern of the von Hippel-Lindau protein in human tissues

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12 December 2020

Inactivation of the p53 gene is not required for tumorigenesis of medullary thyroid carcinoma or pheochromocytoma

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12 December 2020

Long-term evaluation following resection of apparently benign pheochromocytoma(s)/paraganglioma(s)

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12 December 2020

Deoxyribonucleic acid flow cytometric study in pheochromocytomas and its correlation with clinical parameters

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12 December 2020

Tumour angiogenesis and Ki-67 expression in phaeochromocytoma

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12 December 2020

The GDNF/RET signaling pathway and human diseases

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12 December 2020

KI-67 AND hTERT Expression Can Aid in the Distinction between Malignant and Benign Pheochromocytoma and Paraganglioma

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12 December 2020

Familial pheochromocytoma associated with a novel mutation in the von Hippel-Lindau gene

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12 December 2020

Features of malignancy in a benign pheochromocytoma

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12 December 2020

CD44 expression in normal adrenal tissue and adrenal tumours

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12 December 2020

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

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12 December 2020

Von Hippel-Lindau disease: gene to bedside

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12 December 2020

Mutation analysis of glial cell line-derived neurotrophic factor, a ligand for an RET/coreceptor complex, in multiple endocrine neoplasia type 2 and sporadic neuroendocrine tumors

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12 December 2020

Cyanotic heart disease: "low altitude" risk for carotid body tumor?

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12 December 2020

Proliferative index in phaeochromocytomas: does it predict the occurrence of metastases?

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12 December 2020

Expression of neuropeptides and other neuroendocrine markers in human phaeochromocytomas

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12 December 2020

Loss of neurofibromatosis type I (NF1) gene expression in pheochromocytomas from patients without NF1.

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12 December 2020

Genetic predisposition to phaeochromocytoma: analysis of candidate genes GDNF, RET and VHL.

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12 December 2020

Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan

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12 December 2020

p53 alterations and their relationship to SDHD mutations in parasympathetic paragangliomas

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12 December 2020

Usefulness of VEGF, MMP-2, MMP-3 and TIMP-2 serum level evaluation in patients with adrenal tumours

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12 December 2020

The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway

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12 December 2020

Screening for MEN1 mutations in patients with atypical endocrine neoplasia

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12 December 2020

A report of familial carotid body tumors and multiple extra-adrenal pheochromocytomas

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12 December 2020

Expression and prognostic value of c-erbB-2 oncogene product in human phaeochromocytomas

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12 December 2020

Paragangliomas of the head and neck region show complete loss of heterozygosity at 11 q22-q23 in chief cells and the flow-sorted dna aneuploid fraction

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12 December 2020

Paraganglioma of the urinary bladder: can biologic potential be predicted?

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12 December 2020

Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease.

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12 December 2020

Specific genetic change in tumors associated with von Hippel-Lindau disease

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12 December 2020

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A.

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12 December 2020

Loss of NF1 alleles in phaeochromocytomas from patients with type I neurofibromatosis

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12 December 2020

Type 1 neurofibromatosis: a descriptive analysis of the disorder in 1,728 patients.

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12 December 2020

Expression of the RET proto-oncogene in normal human tissues, pheochromocytomas, and other tumors of neural crest origin

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12 December 2020

Sporadic and familial pheochromocytomas are associated with loss of at least two discrete intervals on chromosome 1p

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12 December 2020

Prognostic value of p53, bcl-2, and c-erbB-2 protein expression in phaeochromocytomas

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12 December 2020

Sporadic phaeochromocytomas are rarely associated with germline mutations in the von Hippel-Lindau and RET genes

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12 December 2020

Expression of the ret proto-oncogene product in human normal and neoplastic tissues of neural crest origin

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12 December 2020

A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors

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12 December 2020

Predicting metastasis of pheochromocytomas using DNA flow cytometry and immunohistochemical markers of cell proliferation: A positive correlation between MIB-1 staining and malignant tumor behavior

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12 December 2020

Loss of heterozygosity suggests multiple genetic alterations in pheochromocytomas and medullary thyroid carcinomas

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12 December 2020

Alterations of the SDHD gene locus in midgut carcinoids, Merkel cell carcinomas, pheochromocytomas, and abdominal paragangliomas

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12 December 2020

Progress in understanding structure-function relationships in respiratory chain complex II.

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12 December 2020

Genetic alterations of the RET proto-oncogene in familial and sporadic pheochromocytomas

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12 December 2020

RET proto-oncogene point mutations in sporadic neuroendocrine tumors

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12 December 2020

Low frequency of ras gene mutations in neuroblastomas, pheochromocytomas, and medullary thyroid cancers

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12 December 2020

The clinicopathological features and importance of p53, Rb, and mdm2 expression in phaeochromocytomas and paragangliomas

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12 December 2020

Gene expression profiling predicts clinical outcome of breast cancer

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12 December 2020

Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas

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12 December 2020

Pheochromocytomas and C-cell thyroid neoplasms in transgenic c-mos mice: a model for the human multiple endocrine neoplasia type 2 syndrome

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12 December 2020

Mutation analysis of glial cell line-derived neurotrophic factor (GDNF), a ligand for the RET/GDNF receptor alpha complex, in sporadic phaeochromocytomas.

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12 December 2020

Analysis of the SDHD gene, the susceptibility gene for familial paraganglioma syndrome (PGL1), in pheochromocytomas

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12 December 2020

Expression of interleukin-1 in human pheochromocytoma

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12 December 2020

Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma

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12 December 2020

Sporadic pheochromocytomas are rarely associated with germline mutations in the vhl tumor suppressor gene or the ret protooncogene

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12 December 2020

Morphometric analysis of benign and malignant adrenal pheochromocytomas.

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12 December 2020

Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: correlations with phenotype

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12 December 2020

Increased expression of cyclooxygenase-2 in malignant pheochromocytomas

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12 December 2020

Prediction of Malignant Behavior of Pheochromocytomas and Paragangliomas Using Immunohistochemical Techniques

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12 December 2020

Consistent association of 1p loss of heterozygosity with pheochromocytomas from patients with multiple endocrine neoplasia type 2 syndromes

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12 December 2020

The Hallmarks of Cancer

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12 December 2020

Allelotype of head and neck paragangliomas: Allelic imbalance is confined to the long arm of chromosome 11, the site of the predisposing locusPGL

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12 December 2020

Differential genetic alterations in von Hippel-Lindau syndrome-associated and sporadic pheochromocytomas

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12 December 2020

Dopamine and dopa urinary excretion in patients with pheochromocytoma--diagnostic implications.

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12 December 2020

Somatic and occult germ-line mutations in SDHD, a mitochondrial complex II gene, in nonfamilial pheochromocytoma

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12 December 2020

Oncogene and growth factor expression in MEN 2 and related tumors

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12 December 2020

Deletion mapping of chromosome 1p and 22q in pheochromocytoma.

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12 December 2020

Cancer's deadly signature

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12 December 2020

A multigenic program mediating breast cancer metastasis to bone

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12 December 2020

Differential diagnosis of pheochromocytomas and paragangliomas

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12 December 2020

The relatively high frequency of p53 gene mutations in multiple and malignant phaeochromocytomas

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12 December 2020

Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas.

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12 December 2020

Cytokeratin expression in adrenal phaeochromocytomas and extra-adrenal paragangliomas

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12 December 2020

Elevated levels of telomerase activity in malignant pheochromocytoma

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12 December 2020

Structural biology. Complex II is complex too.

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12 December 2020

Differential loss of chromosome 11q in familial and sporadic parasympathetic paragangliomas detected by comparative genomic hybridization

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12 December 2020

Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: evidence for a VHL-independent pathway in clear cell renal tumourigenesis

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12 December 2020

Leu-M1 immunoreactivity and phaeochromocytoma

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12 December 2020

p53 and p16INK4A mutations during the progression of glomus tumor

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12 December 2020

S100 protein-positive sustentacular cells in malignant and locally aggressive adrenal pheochromocytomas

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12 December 2020

Expression patterns of the c-myc gene in adrenocortical tumors and pheochromocytomas

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12 December 2020

Mutation analysis of the c-mos proto-oncogene and the endothelin-B receptor gene in medullary thyroid carcinoma and phaeochromocytoma

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12 December 2020

High altitude hypoxia and chemodectomas

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12 December 2020

Mutations of the VHL tumour suppressor gene in renal carcinoma

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12 December 2020

Germline SDHD mutation in familial phaeochromocytoma

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12 December 2020

Deletion mapping on the distal third region of chromosome 1p in multiple endocrine neoplasia type IIA

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12 December 2020

Telomerase activity as an indicator of potentially malignant adrenal tumors.

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12 December 2020

Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma

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12 December 2020

Prognostic value of RET proto-oncogene point mutations in malignant and benign, sporadic phaeochromocytomas

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12 December 2020

RET is expressed but not mutated in extra-adrenal paragangliomas

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12 December 2020

Mutations in SDHC cause autosomal dominant paraganglioma, type 3.

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12 December 2020

Mutations of K-ras oncogene in human adrenal tumours in Taiwan

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12 December 2020

Malignant and benign tumors in patients with neurofibromatosis type 1 in a defined Swedish population

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12 December 2020

Identification of novel SDHD mutations in patients with phaeochromocytoma and/or paraganglioma.

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12 December 2020

Carotid body hyperplasia in cystic fibrosis and cyanotic heart disease. A combined morphometric, ultrastructural, and biochemical study

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12 December 2020

Phenotypic dichotomy in mitochondrial complex II genetic disorders.

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12 December 2020

Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours

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12 December 2020

RASSF1A promoter region CpG island hypermethylation in phaeochromocytomas and neuroblastoma tumours

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12 December 2020

Genome-wide detection of chromosomal imbalances in tumors using BAC microarrays

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12 December 2020

Angiogenesis and vascular architecture in pheochromocytomas: distinctive traits in malignant tumors

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12 December 2020

High levels of tyrosine phosphorylated proto-ret in sporadic phenochromocytomas.

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12 December 2020

The RET protooncogene in sporadic pheochromocytomas: frequent MEN 2-like mutations and new molecular defects

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12 December 2020

p53 mutations in adrenal tumors: Caucasian patients do not show the exon 4 "hot spot" found in Taiwan

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12 December 2020

Expression of the apoptosis-suppressing gene BCL-2 in pheochromocytoma is associated with the expression of C-MYC

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12 December 2020

Deletion of genes on chromosome 1 in endocrine neoplasia

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12 December 2020

Absence of somatic SDHD mutations in sporadic neuroendocrine tumors and detection of two germline variants in paraganglioma patients

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12 December 2020

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma

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12 December 2020

Increased expression of tenascin in pheochromocytomas correlates with malignancy

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12 December 2020

c-MYC: more than just a matter of life and death

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12 December 2020

Clinical experience over 48 years with pheochromocytoma

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12 December 2020

Tumor angiogenesis in pheochromocytomas and paragangliomas

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12 December 2020

Molecular and immunohistochemical analysis of P53 in phaeochromocytoma

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12 December 2020

Germline mutations in the vhl gene in patients presenting with phaeochromocytomas

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12 December 2020

Oncogene expression in carotid body tumors

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12 December 2020

Adrenalectomy for familial pheochromocytoma in the laparoscopic era.

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12 December 2020

Genome-wide screening for complete genetic loss in prostate cancer by comparative hybridization onto cDNA microarrays

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12 December 2020

High-level expression of receptor tyrosine kinase Ret and responsiveness to Ret-activating ligands in pheochromocytoma cell lines from neurofibromatosis knockout mice

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12 December 2020

RB-mediated suppression of spontaneous multiple neuroendocrine neoplasia and lung metastases in Rb+/- mice

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12 December 2020

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

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12 December 2020

Nearly all hereditary paragangliomas in the Netherlands are caused by two founder mutations in the SDHD gene

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12 December 2020

Flow cytometric determination of nuclear DNA content in benign adrenal pheochromocytomas

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12 December 2020

Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas

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12 December 2020

Telomerase activity in benign and malignant adrenal tumors

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12 December 2020

C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B

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12 December 2020

Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice

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12 December 2020

Functional consequences of a SDHB gene mutation in an apparently sporadic pheochromocytoma

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12 December 2020

Prognostic markers in pheochromocytoma

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12 December 2020

SDHB mutation analysis in familial and sporadic phaeochromocytoma identifies a novel mutation.

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12 December 2020

Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.

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12 December 2020

National Cancer Data Base report on malignant paragangliomas of the head and neck

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12 December 2020

Changes in clinical features and long-term prognosis in patients with pheochromocytoma

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12 December 2020

Prognostic value of immunohistochemical expression of topoisomerase alpha II, MIB-1, p53, E-cadherin, retinoblastoma gene protein product, and HER-2/neu in adrenal and extra-adrenal pheochromocytomas

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12 December 2020

Neuropeptide Y and neuron-specific enolase levels in benign and malignant pheochromocytomas

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12 December 2020

Expression analysis of RET and the GDNF/GFRalpha-1 and NTN/GFRalpha-2 ligand complexes in pheochromocytomas and paragangliomas

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12 December 2020

Differential heparanase-1 expression in malignant and benign pheochromocytomas

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12 December 2020

Carotid body tumors in inhabitants of altitudes higher than 2000 meters above sea level

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12 December 2020

The von Hippel-Lindau tumor suppressor protein

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12 December 2020

Overexpression of the tumour suppressor gene p53 is not implicated in neuroendocrine tumour carcinogenesis

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12 December 2020

Expression of apoptosis-suppressing gene bcl-2 in human carotid body tumours

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12 December 2020

Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation.

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12 December 2020

Pheochromocytoma: nuclear deoxyribonucleic acid patterns studied by flow cytometry

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12 December 2020

von Recklinghausen's disease and pheochromocytomas

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12 December 2020

Paraganglioma of the lung--developed after exposure to nuclear radiation by the Tschernobyl atomic reactor accident?

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12 December 2020

Hereditary paraganglioma targets diverse paraganglia

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12 December 2020

Loss of heterozygosity on chromosomes 1p and 11p in sporadic pheochromocytoma

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12 December 2020

The pathogenesis of pituitary tumours

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12 December 2020

Von Hippel-Lindau gene alterations in sporadic benign and malignant pheochromocytomas

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12 December 2020

Inhibin/activin betaB-subunit expression in pheochromocytomas favors benign diagnosis

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12 December 2020

Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma

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12 December 2020

Pheochromocytoma, a rare cause of hypertension: long-term follow-up of 55 surgically treated patients.

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12 December 2020

Remarkably suppressed manganese superoxide dismutase activity in malignant pheochromocytoma

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12 December 2020

Expression of c-fos and c-myc proto-oncogenes in human adrenal pheochromocytomas

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12 December 2020

Losses of chromosomes 1p and 3q are early genetic events in the development of sporadic pheochromocytomas

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12 December 2020

Proportion of heritable paraganglioma cases and associated clinical characteristics

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12 December 2020

Clinical differences between benign and malignant pheochromocytomas

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12 December 2020

Autosomal dominant malignant and catecholamine-producing paraganglioma caused by a splice donor site mutation in SDHC.

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12 December 2020

Immunohistochemical characterization of HLA-DR-antigen positive dendritic cells in phaeochromocytomas and paragangliomas as a prognostic marker

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12 December 2020

Neoplasms in neurofibromatosis 1 are related to gender but not to family history of cancer.

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12 December 2020

Immunohistochemical estimations of growth activity to predict biological behavior of pheochromocytomas

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12 December 2020

Absence of TP53 alterations in pheochromocytomas and medullary thyroid carcinomas

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12 December 2020

Telomerase activity in adrenal cortical tumors and pheochromocytomas with reference to clinicopathologic features

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12 December 2020

Deletion analysis of the p16 tumour suppressor gene in phaeochromocytomas

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12 December 2020

Mutations in the RET protooncogene in sporadic pheochromocytomas

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12 December 2020

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

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12 December 2020

Germ-line mutations in nonsyndromic pheochromocytoma

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12 December 2020

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

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12 December 2020

Paragangliomas of the head and neck region. A pathologic study of tumors from 71 patients

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12 December 2020

Malignant pheochromocytoma: clinical, biological, histologic and therapeutic data in a series of 20 patients with distant metastases

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12 December 2020

Expression of insulin-like growth factor (IGF)-II in human prostate, breast, bladder, and paraganglioma tumors

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12 December 2020

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12 December 2020

Transcription profiling of benign and malignant adrenal tumors by cDNA macro-array analysis

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12 December 2020

BCL-2 expression and inhibin-A in adrenal neoplasms: a comparative study

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12 December 2020

Comparative genomic hybridization reveals frequent losses of chromosomes 1p and 3q in pheochromocytomas and abdominal paragangliomas, suggesting a common genetic etiology

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12 December 2020

Improved detection of germline mutations in the von Hippel-Lindau disease tumor suppressor gene

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12 December 2020

Tissue-specific carcinogenesis in transgenic mice expressing the RET proto-oncogene with a multiple endocrine neoplasia type 2A mutation.

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12 December 2020

Profiling breast cancer by array CGH.

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12 December 2020

Survivin: a novel neuroendocrine marker for pheochromocytoma

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12 December 2020

Tumor-specific mutations in the tyrosine kinase domain of the RET proto-oncogene in pheochromocytomas of sporadic type

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12 December 2020

Loss of heterozygosity on the short arm of chromosomes 1 and 3 in sporadic pheochromocytoma and extra-adrenal paraganglioma

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12 December 2020

Mutations of the p53 gene in human functional adrenal neoplasms

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12 December 2020

A comparative immunohistochemical study of phaeochromocytomas and paragangliomas

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12 December 2020

Mutations in the RET proto-oncogene and the von Hippel-Lindau disease tumour suppressor gene in sporadic and syndromic phaeochromocytomas

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12 December 2020

Absent ras gene mutations in human adrenal cortical neoplasms and pheochromocytomas

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12 December 2020

Catecholamine secretion and ploidy in phaeochromocytoma

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12 December 2020

Identifiers

DOI

10.1385/EP:14:4:329

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Dimensions Publication ID

9 August 2017

1037151460

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