Histone deacetylase inhibitors prevent the degradation and restore the activity of glucocerebrosidase in Gaucher disease (Q35641509)

9 August 2017

Histone deacetylase inhibitors prevent the degradation and restore the activity of glucocerebrosidase in Gaucher disease (English)

1 reference

9 August 2017

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Jie Lu

1

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9 August 2017

Chunzhang Yang

2

1 reference

9 August 2017

Masako Chen

3

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9 August 2017

Donald Y Ye

4

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9 August 2017

Russell R Lonser

5

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9 August 2017

Roscoe O Brady

6

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9 August 2017

Zhengping Zhuang

7

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9 August 2017

language of work or name

English

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publication date

12 December 2011

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Proceedings of the National Academy of Sciences of the United States of America

9 August 2017

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9 August 2017

108

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9 August 2017

52

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9 August 2017

21200-21205

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describes a project that uses

9 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3248545/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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An "exacerbate-reverse" strategy in yeast identifies histone deacetylase inhibition as a correction for cholesterol and sphingolipid transport defects in human Niemann-Pick type C disease

12 July 2018

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Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts

12 July 2018

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12 July 2018

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Decreased glucocerebrosidase activity in Gaucher disease parallels quantitative enzyme loss due to abnormal interaction with TCP1 and c-Cbl.

12 July 2018

1 reference

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Molecular basis of reduced glucosylceramidase activity in the most common Gaucher disease mutant, N370S

12 July 2018

1 reference

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Histone deacetylases are critical targets of bortezomib-induced cytotoxicity in multiple myeloma

12 July 2018

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The pharmacological chaperone isofagomine increases the activity of the Gaucher disease L444P mutant form of beta-glucosidase

12 July 2018

1 reference

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12 July 2018

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Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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An acetylation site in the middle domain of Hsp90 regulates chaperone function

12 July 2018

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12 July 2018

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Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention.

12 July 2018

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Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease

12 July 2018

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The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms

12 July 2018

1 reference

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Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

12 July 2018

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Therapeutic strategies to ameliorate lysosomal storage disorders--a focus on Gaucher disease

12 July 2018

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12 July 2018

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12 July 2018

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Impaired trafficking of mutants of lysosomal glucocerebrosidase in Gaucher's disease.

12 July 2018

1 reference

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HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

12 July 2018

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Celastrols as inducers of the heat shock response and cytoprotection.

12 July 2018

1 reference

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METABOLISM OF GLUCOCEREBROSIDES. II. EVIDENCE OF AN ENZYMATIC DEFICIENCY IN GAUCHER'S DISEASE.

12 July 2018

1 reference

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Demonstration of a deficiency of glucocerebroside-cleaving enzyme in Gaucher's disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248545

Biosynthesis of the lysosomal enzyme glucocerebrosidase

12 July 2018

1 reference

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Establishment of a human medulloblastoma cell line and its heterotransplantation into nude mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248545

Posttranslational processing of human lysosomal acid beta-glucosidase: a continuum of defects in Gaucher disease type 1 and type 2 fibroblasts

12 July 2018

1 reference

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High-fat diet feeding impairs both the expression and activity of AMPKa in rats' skeletal muscle

12 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1119181109

Chemical chaperones and permissive temperatures alter localization of Gaucher disease associated glucocerebrosidase variants

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248545

Twin pairs showing discordance of phenotype in adult Gaucher's disease

25 September 2018

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12 December 2020

Structure of the N-asparagine-linked oligosaccharide units of human placental beta-glucocerebrosidase

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12 December 2020

Quercetin suppresses heat shock response by down regulation of HSF1

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12 December 2020

Gaucher disease: variability in phenotype among siblings

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12 December 2020

Folding and quality control of the VHL tumor suppressor proceed through distinct chaperone pathways

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12 December 2020

ER retention and degradation as the molecular basis underlying Gaucher disease heterogeneity

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12 December 2020

Improved intracellular delivery of glucocerebrosidase mediated by the HIV-1 TAT protein transduction domain

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1119181109

1 reference

9 August 2017

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1 reference

9 August 2017

1 reference