Distinct cell guidance pathways controlled by the Rac and Rho GEF domains of UNC-73/TRIO in Caenorhabditis elegans (Q35644790)

9 August 2017

title

Distinct cell guidance pathways controlled by the Rac and Rho GEF domains of UNC-73/TRIO in Caenorhabditis elegans (English)

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9 August 2017

main subject

Caenorhabditis elegans

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author name string

Nancy Marcus-Gueret

series ordinal

1

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9 August 2017

Kristopher L Schmidt

series ordinal

2

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9 August 2017

Eve G Stringham

series ordinal

3

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9 August 2017

language of work or name

English

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publication date

13 October 2011

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9 August 2017

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9 August 2017

volume

190

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9 August 2017

issue

1

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9 August 2017

page(s)

129-142

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Navigating the cell: UNC-53 and the navigators, a family of cytoskeletal regulators with multiple roles in cell migration, outgrowth and trafficking

9 August 2017

cites work

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27 July 2018

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Complex network of Wnt signaling regulates neuronal migrations during Caenorhabditis elegans development

27 July 2018

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The slit receptor EVA-1 coactivates a SAX-3/Robo mediated guidance signal in C. elegans

27 July 2018

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VAB-8, UNC-73 and MIG-2 regulate axon polarity and cell migration functions of UNC-40 in C. elegans

27 July 2018

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The UNC-73/Trio RhoGEF-2 domain is required in separate isoforms for the regulation of pharynx pumping and normal neurotransmission in C. elegans

27 July 2018

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Mouse neuron navigator 1, a novel microtubule-associated protein involved in neuronal migration

27 July 2018

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Regulation of WASP/WAVE proteins: making a long story short

27 July 2018

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Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53

27 July 2018

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Functional analysis of the Caenorhabditis elegans UNC-73B PH domain demonstrates a role in activation of the Rac GTPase in vitro and axon guidance in vivo

27 July 2018

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Rac proteins and the control of axon development

27 July 2018

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Formins: signaling effectors for assembly and polarization of actin filaments

27 July 2018

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Molecular mechanisms of axon guidance

27 July 2018

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Tubes and the single C. elegans excretory cell

27 July 2018

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unc-53 controls longitudinal migration in C. elegans

27 July 2018

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Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans

27 July 2018

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A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos

27 July 2018

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The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans

27 July 2018

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A RHO GTPase-mediated pathway is required during P cell migration in Caenorhabditis elegans

27 July 2018

1 reference

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C. elegans slit acts in midline, dorsal-ventral, and anterior-posterior guidance via the SAX-3/Robo receptor.

27 July 2018

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Switching repulsion to attraction: changing responses to slit during transition in mesoderm migration

27 July 2018

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Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans

27 July 2018

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Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

The Drosophila trio plays an essential role in patterning of axons by regulating their directional extension.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

A Wnt signaling pathway controls hox gene expression and neuroblast migration in C. elegans

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

egl-17 encodes an invertebrate fibroblast growth factor family member required specifically for sex myoblast migration in Caenorhabditis elegans

27 July 2018

1 reference

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Genetic enhancers of sem-5 define components of the gonad-independent guidance mechanism controlling sex myoblast migration in Caenorhabditis elegans hermaphrodites

27 July 2018

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Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6.

27 July 2018

1 reference

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The genetics of Caenorhabditis elegans

27 July 2018

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Genetics of cell and axon migrations in Caenorhabditis elegans

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

The cell migration molecule UNC-53/NAV2 is linked to the ARP2/3 complex by ABI-1.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

C. elegans VAB-8 and UNC-73 regulate the SAX-3 receptor to direct cell and growth-cone migrations

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

The WASP-WAVE protein network: connecting the membrane to the cytoskeleton

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

Distinct regulatory elements mediate similar expression patterns in the excretory cell of Caenorhabditis elegans.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

The VAB-1 Eph receptor tyrosine kinase and SAX-3/Robo neuronal receptors function together during C. elegans embryonic morphogenesis

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

A pair as a minimum: the two fibroblast growth factors of the nematode Caenorhabditis elegans

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

Differential functions of the C. elegans FGF receptor in axon outgrowth and maintenance of axon position.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

UNC-71, a disintegrin and metalloprotease (ADAM) protein, regulates motor axon guidance and sex myoblast migration in C. elegans

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

Distinct rac activation pathways control Caenorhabditis elegans cell migration and axon outgrowth

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

ced-10 Rac and mig-2 function redundantly and act with unc-73 trio to control the orientation of vulval cell divisions and migrations in Caenorhabditis elegans

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

The guanine nucleotide exchange factor trio mediates axonal development in the Drosophila embryo

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

vab-8 is a key regulator of posteriorly directed migrations in C. elegans and encodes a novel protein with kinesin motor similarity

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

The C. elegans gene vab-8 guides posteriorly directed axon outgrowth and cell migration.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249371

Axonal guidance defects in a Caenorhabditis elegans mutant reveal cell-extrinsic determinants of neuronal morphology

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21996675

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Wnt signals and frizzled activity orient anterior-posterior axon outgrowth in C. elegans

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21996675

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Alternative splicing affecting a novel domain in the C. elegans EGL-15 FGF receptor confers functional specificity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21996675

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1534/GENETICS.111.134429

1 reference

9 August 2017

1 reference

9 August 2017

1 reference