Incorporation of 5-fluorouracil into U2 snRNA blocks pseudouridylation and pre-mRNA splicing in vivo (Q35646810)

9 August 2017

title

Incorporation of 5-fluorouracil into U2 snRNA blocks pseudouridylation and pre-mRNA splicing in vivo (English)

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9 August 2017

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Xinliang Zhao

1

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9 August 2017

Yi-Tao Yu

series ordinal

2

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9 August 2017

language of work or name

English

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publication date

14 December 2006

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9 August 2017

published in

Nucleic Acids Research

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9 August 2017

volume

35

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9 August 2017

issue

2

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9 August 2017

page(s)

550-558

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In vivo assembly of functional U7 snRNP requires RNA backbone flexibility within the Sm-binding site

9 August 2017

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5-fluorouracil enhances exosome-dependent accumulation of polyadenylated rRNAs

12 July 2018

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Modified nucleotides at the 5' end of human U2 snRNA are required for spliceosomal E-complex formation

12 July 2018

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Pseudouridines in and near the branch site recognition region of U2 snRNA are required for snRNP biogenesis and pre-mRNA splicing in Xenopus oocytes

12 July 2018

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Fluorinated pyrimidines, a new class of tumour-inhibitory compounds

12 July 2018

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5-Fluorouracil: mechanisms of action and clinical strategies

12 July 2018

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Pseudouridylation (Psi) of U2 snRNA in S. cerevisiae is catalyzed by an RNA-independent mechanism

12 July 2018

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Ribosome structure and activity are altered in cells lacking snoRNPs that form pseudouridines in the peptidyl transferase center

12 July 2018

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An H/ACA guide RNA directs U2 pseudouridylation at two different sites in the branchpoint recognition region in Xenopus oocytes.

12 July 2018

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Sculpting of the spliceosomal branch site recognition motif by a conserved pseudouridine

12 July 2018

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Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs

12 July 2018

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Disruption of p53 in human cancer cells alters the responses to therapeutic agents

12 July 2018

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Modifications of U2 snRNA are required for snRNP assembly and pre-mRNA splicing

12 July 2018

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An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug

12 July 2018

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Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation

12 July 2018

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A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

12 July 2018

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Stabilization of RNA stacking by pseudouridine

12 July 2018

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Pseudouridine formation in U2 small nuclear RNA.

12 July 2018

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Incorporation of 5-fluorouracil into U2 and U6 snRNA inhibits mRNA precursor splicing.

12 July 2018

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5-fluorouracil modulation of dihydrofolate reductase RNA levels in methotrexate-resistant KB cells

12 July 2018

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5-Fluorouracil augmentation of dihydrofolate reductase gene transcripts containing intervening sequences in methotrexate-resistant KB cells.

12 July 2018

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Effects of 5-fluorouracil on globin mRNA synthesis in murine erythroleukemia cells

12 July 2018

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5-Fluorouracil augmentation of dihydrofolate reductase RNA containing contiguous exon and intron sequences in KB7B cells.

12 July 2018

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5-Fluorouracil inhibits dihydrofolate reductase precursor mRNA processing and/or nuclear mRNA stability in methotrexate-resistant KB cells

12 July 2018

1 reference

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Effects of 5-fluorouracil on cytotoxicity and RNA metabolism in human colonic carcinoma cells

12 July 2018

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Correlation between ribosomal RNA production and RNA-directed fluoropyrimidine cytotoxicity

12 July 2018

1 reference

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Effect of 5-fluorouracil combination therapy on RNA processing in human colonic carcinoma cells

12 July 2018

1 reference

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Metabolism and mechanism of action of 5-fluorouracil

12 July 2018

1 reference

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Effect of 5-fluorouracil on RNA metabolism in Novikoff hepatoma cells

12 July 2018

1 reference

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Modulation of 5-fluorouracil metabolism by thymidine. In vivo and in vitro studies on RNA-directed effects in rat liver and hepatoma

12 July 2018

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12 December 2020

Lethality associated with incorporation of 5-fluorouracil into preribosomal RNA

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12 December 2020

Fluoropyrimidine-mediated changes in small nuclear RNA

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12 December 2020

The inhibitory effects of 5-fluorouracil on the metabolism of preribosomal and ribosomal RNA in L-1210 cells in vitro

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12 December 2020

Acute effect of 5-fluorouracil on cytoplasmic and nuclear dihydrofolate reductase messenger RNA metabolism

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12 December 2020

Precursor-dependent differences in the incorporation of fluorouracil in RNA

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12 December 2020

5-Fluorouracil substitution alters pre-mRNA splicing in vitro

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12 December 2020

Inhibition of pre-mRNA splicing by 5-fluoro-, 5-chloro-, and 5-bromouridine

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12 December 2020

Specific inhibition of pre-ribosomal RNA processing in extracts from the lymphosarcoma cells treated with 5-fluorouracil

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12 December 2020

Crystal structure of unmodified tRNA(Gln) complexed with glutaminyl-tRNA synthetase and ATP suggests a possible role for pseudo-uridines in stabilization of RNA structure

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12 December 2020

RNA synthesis in the liver of rats treated with 5-fluorouracil

1 reference

12 December 2020

Identifiers

DOI

10.1093/NAR/GKL1084

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9 August 2017

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9 August 2017

1 reference