D,L-sulforaphane-induced apoptosis in human breast cancer cells is regulated by the adapter protein p66Shc (Q35659007)

9 August 2017

title

D,L-sulforaphane-induced apoptosis in human breast cancer cells is regulated by the adapter protein p66Shc (English)

1 reference

9 August 2017

2

Shivendra V Singh

1 reference

9 August 2017

Kozue Sakao

1

1 reference

9 August 2017

publication date

1 February 2012

1 reference

Journal of Cellular Biochemistry

9 August 2017

published in

1 reference

9 August 2017

volume

113

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9 August 2017

issue

2

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9 August 2017

page(s)

599-610

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Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer.

9 August 2017

cites work

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Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells

27 July 2018

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Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells

27 July 2018

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Sulforaphane Increases Cyclin-Dependent Kinase Inhibitor, p21 Protein in Human Oral Carcinoma Cells and Nude Mouse Animal Model to Induce G(2)/M Cell Cycle Arrest

27 July 2018

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Nrf2: friend or foe for chemoprevention?

27 July 2018

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Involvement of Pin1 induction in epithelial-mesenchymal transition of tamoxifen-resistant breast cancer cells

27 July 2018

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Cellular responses to cancer chemopreventive agent D,L-sulforaphane in human prostate cancer cells are initiated by mitochondrial reactive oxygen species

27 July 2018

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Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells

27 July 2018

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The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation

27 July 2018

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The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

27 July 2018

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Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability

27 July 2018

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The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells

27 July 2018

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Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak.

27 July 2018

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Selective fluorescent imaging of superoxide in vivo using ethidium-based probes

27 July 2018

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Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention.

27 July 2018

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Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5.

27 July 2018

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Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.

27 July 2018

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Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species.

27 July 2018

1 reference

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Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis

27 July 2018

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Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2.

27 July 2018

1 reference

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p66Shc protein is upregulated by steroid hormones in hormone-sensitive cancer cells and in primary prostate carcinomas

27 July 2018

1 reference

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Cancer chemoprevention with dietary phytochemicals

27 July 2018

1 reference

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Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo

27 July 2018

1 reference

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The chemical diversity and distribution of glucosinolates and isothiocyanates among plants

27 July 2018

1 reference

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The p66shc adaptor protein controls oxidative stress response and life span in mammals

27 July 2018

1 reference

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CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253217

Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates

27 July 2018

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A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253217

Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent

27 July 2018

1 reference

p66 Shc and tyrosine-phosphorylated Shc in primary breast tumors identify patients likely to relapse despite tamoxifen therapy

21 January 2018

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Inhibition of carcinogenesis by isothiocyanates

21 January 2018

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Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells

21 January 2018

1 reference

The prolyl isomerase Pin1 enhances HER-2 expression and cellular transformation via its interaction with mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1.

21 January 2018

1 reference

Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain.

21 January 2018

1 reference

Cancer prevention: from 1727 to milestones of the past 100 years

21 January 2018

1 reference

A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.

21 January 2018

1 reference

Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.

21 January 2018

1 reference

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway

21 January 2018

1 reference

The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.

21 January 2018

1 reference

p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.

21 January 2018

1 reference

Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis

21 January 2018

1 reference

Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C.

21 January 2018

1 reference

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.

21 January 2018

1 reference

Pin1 overexpression is associated with poor differentiation and survival in oral squamous cell carcinoma

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253217

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

25 September 2018

1 reference

Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21956685

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21956685

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21956685

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/JCB.23386

1 reference

9 August 2017

1 reference

9 August 2017

1 reference