Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P (Q35660591)

9 August 2017

Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P (English)

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9 August 2017

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S Sturiale

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9 August 2017

G Barbara

2

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9 August 2017

B Qiu

3

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9 August 2017

M Figini

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9 August 2017

P Geppetti

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9 August 2017

N Gerard

6

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9 August 2017

C Gerard

7

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9 August 2017

E F Grady

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9 August 2017

N W Bunnett

9

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9 August 2017

S M Collins

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9 August 2017

language of work or name

English

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publication date

1 September 1999

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Proceedings of the National Academy of Sciences of the United States of America

9 August 2017

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9 August 2017

96

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9 August 2017

11653-11658

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9 August 2017

20

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Neuropeptide regulation of human dermal microvascular endothelial cell ICAM-1 expression and function.

9 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

Desensitization of the neurokinin-1 receptor (NK1-R) in neurons: effects of substance P on the distribution of NK1-R, Galphaq/11, G-protein receptor kinase-2/3, and beta-arrestin-1/2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

Acute ACE inhibition causes plasma extravasation in mice that is mediated by bradykinin and substance P.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

Neurokinin-1 (NK-1) receptor is required in Clostridium difficile- induced enteritis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

The control of microvascular permeability and blood pressure by neutral endopeptidase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

Substance P and bradykinin stimulate plasma extravasation in the mouse gastrointestinal tract and pancreas.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

Regulatory mechanisms that modulate signalling by G-protein-coupled receptors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

Neutral endopeptidase modulation of septic shock.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

Neurotransmitter functions of mammalian tachykinins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

Substance P induces ion secretion in mouse small intestine through effects on enteric nerves and mast cells.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

Direct observation of substance P-induced internalization of neurokinin 1 (NK1) receptors at sites of inflammation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

Interactions between neutral endopeptidase (EC 3.4.24.11) and the substance P (NK1) receptor expressed in mammalian cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

Inhibition of neutral endopeptidase potentiates neurogenic inflammation in the rat trachea

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

Increased levels of substance P in the myenteric plexus of Trichinella-infected rats

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

Neurogenic inflammation. A model for studying efferent actions of sensory nerves

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

Mechanisms of desensitization and resensitization of G protein-coupled neurokinin1 and neurokinin2 receptors.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

Downregulation of neutral endopeptidase (EC 3.4.24.11) in the inflamed rat intestine.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18089

Hapten-induced chronic colitis in the rat: alternatives to trinitrobenzene sulfonic acid

25 September 2018

1 reference

12 December 2020

Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum

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12 December 2020

Relationship between arachidonic acid metabolism, myeloperoxidase activity and leukocyte infiltration in a rat model of inflammatory bowel disease

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12 December 2020

Colonic substance P levels are increased in ulcerative colitis and decreased in chronic severe constipation

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12 December 2020

Neurogenic inflammation of the rat trachea: fate of neutrophils that adhere to venules

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12 December 2020

Identifiers

DOI

10.1073/PNAS.96.20.11653

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9 August 2017

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9 August 2017

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