An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists. (Q35669634)

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25 December 2019

title

An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists (English)

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25 December 2019

4

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25 December 2019

Michael R Baldwin

7

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25 December 2019

author name string

Lisa M Eubanks

1

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25 December 2019

Mark S Hixon

2

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25 December 2019

Wei Jin

3

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25 December 2019

Colin M Clancy

5

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25 December 2019

William H Tepp

6

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25 December 2019

Carl J Malizio

8

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25 December 2019

Michael C Goodnough

9

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25 December 2019

Joseph T Barbieri

10

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25 December 2019

Eric A Johnson

11

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25 December 2019

Dale L Boger

12

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25 December 2019

Tobin J Dickerson

13

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25 December 2019

Kim D Janda

14

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language of work or name

English

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publication date

9 February 2007

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Proceedings of the National Academy of Sciences of the United States of America

25 December 2019

published in

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25 December 2019

volume

104

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25 December 2019

issue

8

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25 December 2019

page(s)

2602-2607

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The use of small molecules to investigate molecular mechanisms and therapeutic targets for treatment of botulinum neurotoxin A intoxication

25 December 2019

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Identification of a potent botulinum neurotoxin a protease inhibitor using in situ lead identification chemistry

27 July 2018

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A credit-card library approach for disrupting protein-protein interactions

27 July 2018

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Discovery of acetylcholinesterase peripheral anionic site ligands through computational refinement of a directed library

27 July 2018

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The medicinal chemistry of botulinum, ricin and anthrax toxins

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Solution‐Phase Combinatorial Libraries: Modulating Cellular Signaling by Targeting Protein–Protein or Protein–DNA Interactions

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Solution-phase synthesis of combinatorial libraries designed to modulate protein-protein or protein-DNA interactions

27 July 2018

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Unraveling hot spots in binding interfaces: progress and challenges

27 July 2018

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Clostridium botulinum and its neurotoxins: a metabolic and cellular perspective

27 July 2018

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Protein functional epitopes: hot spots, dynamics and combinatorial libraries

27 July 2018

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

27 July 2018

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Development of vaccines for prevention of botulism

27 July 2018

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Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 A resolution

27 July 2018

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Conservation of polar residues as hot spots at protein interfaces

27 July 2018

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Antagonism of botulinum toxin A-mediated muscle paralysis by 3, 4-diaminopyridine delivered via osmotic minipumps

27 July 2018

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Botulinum neurotoxin A blocks synaptic vesicle exocytosis but not endocytosis at the nerve terminal

27 July 2018

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The atomic structure of protein-protein recognition sites

27 July 2018

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Anatomy of hot spots in protein interfaces

27 July 2018

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Lack of effect of Miller Fisher sera/plasmas on transmitter release from PC12 cells

27 July 2018

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Protection by the heavy metal chelator N,N,N',N'-tetrakis (2-pyridylmethyl)ethylenediamine (TPEN) against the lethal action of botulinum neurotoxin A and B.

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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Statistical analysis of a rapid in vivo method for the titration of the toxin of Clostridium botulinum

27 July 2018

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27 July 2018

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Crystal structure of botulinum neurotoxin type A and implications for toxicity

27 July 2018

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Human botulism immune globulin for the treatment of infant botulism

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A high-affinity competitive inhibitor of type A botulinum neurotoxin protease activity

21 January 2018

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Substrate recognition strategy for botulinum neurotoxin serotype A.

21 January 2018

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The C-terminus of botulinum neurotoxin type A light chain contributes to solubility, catalysis, and stability

21 January 2018

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Vitamin B2-mediated cellular photoinhibition of botulinum neurotoxin A.

21 January 2018

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Functional characterisation of tetanus and botulinum neurotoxins binding domains

21 January 2018

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25 September 2018

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12 December 2020

Persistence of botulinum neurotoxin action in cultured spinal cord cells

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12 December 2020

Botulinum neurotoxin A activity is dependent upon the presence of specific gangliosides in neuroblastoma cells expressing synaptotagmin I

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12 December 2020

Intimate details of the most poisonous poison

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12 December 2020

Higher order iminodiacetic acid libraries for probing protein-protein interactions

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12 December 2020

Identification of a botulinum neurotoxin A protease inhibitor displaying efficacy in a cellular model

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12 December 2020

Serotype-selective, small-molecule inhibitors of the zinc endopeptidase of botulinum neurotoxin serotype A

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Identifiers

DOI

10.1073/PNAS.0611213104

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293454%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

0 references

1 reference

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25 December 2019

PubMed publication ID

17293454

1 reference