Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes (Q35669992)

9 August 2017

title

Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes (English)

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9 August 2017

June M Brownlee

1

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9 August 2017

Erik Carlson

2

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9 August 2017

Amy C Milne

3

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9 August 2017

Erika Pape

4

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9 August 2017

David H T Harrison

5

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9 August 2017

publication date

2 November 2006

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9 August 2017

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9 August 2017

volume

34

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9 August 2017

issue

6

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9 August 2017

page(s)

424-444

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Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial

9 August 2017

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High-resolution crystal structure of aldose reductase complexed with the novel sulfonyl-pyridazinone inhibitor exhibiting an alternative active site anchoring group

12 July 2018

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The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48

12 July 2018

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Thermodynamic rules for the design of high affinity HIV-1 protease inhibitors with adaptability to mutations and high selectivity towards unwanted targets

12 July 2018

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12 July 2018

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Structural and kinetic modifications of aldose reductase by S-nitrosothiols

12 July 2018

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Selective recognition of glutathiolated aldehydes by aldose reductase

12 July 2018

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Diabetic neuropathies

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12 July 2018

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New concepts and insights on pathogenesis and treatment of diabetic complications: polyol pathway and its inhibition

12 July 2018

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The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant

12 July 2018

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Comparative anatomy of the aldo-keto reductase superfamily

12 July 2018

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Aldose reductase inhibitors: the end of an era or the need for different trial designs?

12 July 2018

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A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil

12 July 2018

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Refined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat

12 July 2018

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Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme

12 July 2018

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An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate

12 July 2018

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Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and alrestatin-like inhibitors

12 July 2018

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Human aldose reductase: rate constants for a mechanism including interconversion of ternary complexes by recombinant wild-type enzyme

12 July 2018

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Novel NADPH-binding domain revealed by the crystal structure of aldose reductase

12 July 2018

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An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications

12 July 2018

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Catalytic effectiveness of human aldose reductase. Critical role of C-terminal domain

12 July 2018

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Hyperglycemia, Polyol Metabolism, and Complications of Diabetes Mellitus

12 July 2018

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Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors

12 July 2018

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Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study

25 September 2018

1 reference

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Redox signaling and the emerging therapeutic potential of thiol antioxidants

25 September 2018

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Human aldose reductase: subtle effects revealed by rapid kinetic studies of the C298A mutant enzyme.

25 September 2018

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Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy

25 September 2018

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12 December 2020

Overcoming roadblocks in lead optimization: a thermodynamic perspective

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12 December 2020

Comparison of hydrogen determination with X-ray and neutron crystallography in a human aldose reductase–inhibitor complex

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12 December 2020

Improved methods for building protein models in electron density maps and the location of errors in these models

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12 December 2020

Activation of aldose reductase in rat lens and metal-ion chelation by aldose reductase inhibitors and lipoic acid

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12 December 2020

The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity

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12 December 2020

Diabetes complications and their potential prevention: aldose reductase inhibition and other approaches

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12 December 2020

10.1016/J.BIOORG.2006.09.004

Identifiers

DOI

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9 August 2017

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9 August 2017

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