Click Chemistry in Lead Optimization of Boronic Acids as β-Lactamase Inhibitors (Q35671797)

8 January 2018

title

Click Chemistry in Lead Optimization of Boronic Acids as β-Lactamase Inhibitors (English)

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8 January 2018

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boronic acids

15 July 2023

5

Robert A Bonomo

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8 January 2018

Emilia Caselli

1

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8 January 2018

Chiara Romagnoli

2

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8 January 2018

Roza Vahabi

3

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8 January 2018

Magdalena A Taracila

4

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8 January 2018

Fabio Prati

6

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8 January 2018

language of work or name

English

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publication date

10 July 2015

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8 January 2018

Journal of Medicinal Chemistry

published in

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8 January 2018

volume

58

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8 January 2018

issue

14

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8 January 2018

page(s)

5445-5458

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8 January 2018

Synthesis of 1,2,3-triazol-1-yl-methaneboronic acids via click chemistry: an easy access to a new potential scaffold for protease inhibitors.

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New β-lactamase inhibitors: a therapeutic renaissance in an MDR world

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Design and Exploration of Novel Boronic Acid Inhibitors Reveals Important Interactions with a Clavulanic Acid-Resistant Sulfhydryl-Variable (SHV) β-Lactamase

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The impact of click chemistry in medicinal chemistry

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Classification of scaffold-hopping approaches

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Microbial efflux pump inhibition: tactics and strategies

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Therapeutic potential of boron-containing compounds

27 July 2018

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Exploring sequence requirements for C₃/C₄ carboxylate recognition in the Pseudomonas aeruginosa cephalosporinase: Insights into plasticity of the AmpC β-lactamase

27 July 2018

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Boron-containing inhibitors of synthetases

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Design, Synthesis, Crystal Structures, and Antimicrobial Activity of Sulfonamide Boronic Acids as β-Lactamase Inhibitors

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Prospects for the next anti-Pseudomonas drug

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Not boring at all. Boron is the new carbon in the quest for novel drug candidates

27 July 2018

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Strategic Design of an Effective -Lactamase Inhibitor: LN-1-255, A 6-ALKYLIDENE-2'-SUBSTITUTED PENICILLIN SULFONE

27 July 2018

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NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007

27 July 2018

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Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes.

27 July 2018

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Recognition and resistance in TEM beta-lactamase

27 July 2018

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Nanomolar inhibitors of AmpC beta-lactamase

27 July 2018

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Amino acid substitutions at Ambler position Gly238 in the SHV-1 beta-lactamase: exploring sequence requirements for resistance to penicillins and cephalosporins

27 July 2018

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A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes

27 July 2018

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NMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities

27 July 2018

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Energetic, structural, and antimicrobial analyses of beta-lactam side chain recognition by beta-lactamases

27 July 2018

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Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,)

27 July 2018

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

27 July 2018

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6-(substituted methylene)penems, potent broad spectrum inhibitors of bacterial beta-lactamase. V. Chiral 1,2,3-triazolyl derivatives.

27 July 2018

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Click chemistry in peptide-based drug design

27 July 2018

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Focusing on boron in medicinal chemistry

25 September 2018

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Cu-catalyzed azide-alkyne cycloaddition

25 September 2018

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Structure-based optimization of cephalothin-analogue boronic acids as β-lactamase inhibitors

25 September 2018

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Probing active site chemistry in SHV beta-lactamase variants at Ambler position 244. Understanding unique properties of inhibitor resistance

25 September 2018

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Structure, function, and inhibition along the reaction coordinate of CTX-M beta-lactamases

25 September 2018

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Detailed analysis of grid-based molecular docking: A case study of CDOCKER-A CHARMm-based MD docking algorithm.

25 September 2018

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Effect of an amino acid insertion into the omega loop region of a class C beta-lactamase on its substrate specificity

25 September 2018

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Inhibitors of HIV-1 protease by using in situ click chemistry

25 September 2018

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12 December 2020

Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists

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12 December 2020

Mutagenesis of amino acid residues in the SHV-1 beta-lactamase: the premier role of Gly238Ser in penicillin and cephalosporin resistance

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12 December 2020

The antibacterial lead discovery challenge

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12 December 2020

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12 December 2020

10.1021/ACS.JMEDCHEM.5B00341

Identifiers

DOI

1 reference

8 January 2018

PMCID

5744665

1 reference

8 January 2018

PubMed ID

26102369

1 reference

8 January 2018