Review of the pharmacological and clinical profile of rimcazole. (Q35673122)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14978511%20AND%20SRC:MED&resulttype=core&format=json

24 November 2019

review article

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title

Review of the pharmacological and clinical profile of rimcazole (English)

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24 November 2019

author name string

Deborah L Gilmore

series ordinal

1

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24 November 2019

Yun Liu

series ordinal

2

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24 November 2019

Rae R Matsumoto

series ordinal

3

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24 November 2019

publication date

1 January 2004

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CNS Neuroscience & Therapeutics

24 November 2019

published in

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24 November 2019

volume

10

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24 November 2019

issue

1

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24 November 2019

page(s)

1-22

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Kappa opioid receptor agonists inhibit sigma-1 (sigma 1) receptor binding in guinea-pig brain, liver and spleen: autoradiographical evidence

24 November 2019

cites work

1 reference

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Blockade by sigma site ligands of high voltage-activated Ca2+ channels in rat and mouse cultured hippocampal pyramidal neurones

21 January 2018

1 reference

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BW 234U, (cis-9-[3-(3,5-dimethyl-1-piperazinyl)propyl]carbazole dihydrochloride): a novel antipsychotic agent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2004.TB00001.X

Blockade by sigma site ligands of N-methyl-D-aspartate-evoked responses in rat and mouse cultured hippocampal pyramidal neurones

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2004.TB00001.X

Neuroprotective effect of sigma(1)-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is linked to reduced neuronal nitric oxide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2004.TB00001.X

Characterization of [3H]desmethylimipramine binding in bovine adrenal medulla: interactions with sigma- and (or) phencyclidine-receptor ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2004.TB00001.X

A potential antidepressant activity of SA4503, a selective sigma 1 receptor agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2004.TB00001.X

Two novel sigma receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity

21 January 2018

1 reference

12 December 2020

Effect of local intracerebral administration of EMD 57445, a selective sigma receptor ligand, on the locomotor activity of the rat.

1 reference

12 December 2020

Involvement of the serotonergic neuronal system in phencyclidine-induced place aversion in rats.

1 reference

12 December 2020

Targeting sigma receptor-binding benzamides as in vivo diagnostic and therapeutic agents for human prostate tumors.

1 reference

12 December 2020

Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues

1 reference

12 December 2020

Effect of ploidy, recruitment, environmental factors, and tamoxifen treatment on the expression of sigma-2 receptors in proliferating and quiescent tumour cells

1 reference

12 December 2020

Murine models of depression

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12 December 2020

Biphasic effect of sigma receptor ligands on the extracellular concentration of dopamine in the striatum of the rat

1 reference

12 December 2020

The antitussive activity of delta-opioid receptor stimulation in guinea pigs

1 reference

12 December 2020

Effects of repeated phencyclidine treatment on serotonin transporter in rat brain

1 reference

12 December 2020

Sigma-2 receptors as a biomarker of proliferation in solid tumours

1 reference

12 December 2020

Antidepressant drugs appear to enhance cocaine-induced toxicity

1 reference

12 December 2020

Effect of sigma ligands on the cocaine-induced convulsions in mice

1 reference

12 December 2020

Sigma ligands inhibit the growth of small cell lung cancer cells

1 reference

12 December 2020

Effects of Hypericum perforatum extract on ethanol intake, and on behavioral despair: a search for the neurochemical systems involved

1 reference

12 December 2020

Immunocytochemical assessment of sigma-1 receptor and human sterol isomerase in breast cancer and their relationship with a series of prognostic factors

1 reference

12 December 2020

Involvement of sigma 1 receptors in methamphetamine-induced behavioral sensitization in rats.

1 reference

12 December 2020

Involvement of direct inhibition of NMDA receptors in the effects of sigma-receptor ligands on glutamate neurotoxicity in vitro

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12 December 2020

N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice

1 reference

12 December 2020

Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice

1 reference

12 December 2020

The antidepressant-like effect induced by sigma(1)-receptor agonists and neuroactive steroids in mice submitted to the forced swimming test

1 reference

12 December 2020

Modulation of dopamine uptake in rat nucleus accumbens: effect of specific dopamine receptor antagonists and sigma ligands

1 reference

12 December 2020

Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters

1 reference

12 December 2020

[3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter

1 reference

12 December 2020

Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell lines

1 reference

12 December 2020

Receptor mechanisms and circuitry underlying NMDA antagonist neurotoxicity

1 reference

12 December 2020

Ketamine-induced c-Fos expression in the mouse posterior cingulate and retrosplenial cortices is mediated not only via NMDA receptors but also via sigma receptors

1 reference

12 December 2020

Sigma receptors: from discovery to highlights of their implications in the cardiovascular system

1 reference

12 December 2020

Assessing antidepressant activity in rodents: recent developments and future needs

1 reference

12 December 2020

sigma(2) Receptors regulate changes in sphingolipid levels in breast tumor cells

1 reference

12 December 2020

Effects of sigma ligands on NMDA receptor function in the bulbectomy model of depression: a behavioural study in the rat.

1 reference

12 December 2020

Involvement of sigma receptors in the behavioral effects of cocaine: evidence from novel ligands and antisense oligodeoxynucleotides

1 reference

12 December 2020

Sigma(1) (sigma(1)) receptor antagonists represent a new strategy against cocaine addiction and toxicity

1 reference

12 December 2020

Probes for the dopamine transporter: new leads toward a cocaine-abuse therapeutic--A focus on analogues of benztropine and rimcazole

1 reference

12 December 2020

Antagonism of NMDA receptors by sigma receptor ligands attenuates chemical ischemia-induced neuronal death in vitro

1 reference

12 December 2020

Sigma1 receptor agonist-mediated regulation of N-methyl-D-aspartate-stimulated [3H]dopamine release is dependent upon protein kinase C.

1 reference

12 December 2020

Potent sigma 1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine provides ischemic neuroprotection without altering dopamine accumulation in vivo in rats

1 reference

12 December 2020

Behavioral effects of rimcazole analogues alone and in combination with cocaine

1 reference

12 December 2020

Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents

1 reference

12 December 2020

Sigma (σ) antagonist BMY 14802 prevents methamphetamine-induced sensitization

1 reference

12 December 2020

A proposal for the classification of sigma binding sites

1 reference

12 December 2020

Competitive interactions at [3H]1,3-di(2-tolyl)guanidine (DTG)-defined sigma recognition sites in guinea pig brain

1 reference

12 December 2020

Persistent supersensitivity of sigma receptors develops during repeated methamphetamine treatment

1 reference

12 December 2020

Characterization of the binding of [3H](+)-pentazocine to sigma recognition sites in guinea pig brain

1 reference

12 December 2020

Characterization of specific binding sites for [3H]-1,3-di-o-tolyl-guanidine (DTG) in the rat glioma cell line C6-BU-1

1 reference

12 December 2020

Haloperidol prevents induction of the hsp70 heat shock gene in neurons injured by phencyclidine (PCP), MK801, and ketamine

1 reference

12 December 2020

In vivo electrophysiological evidence for a selective modulation of N-methyl-D-aspartate-induced neuronal activation in rat CA3 dorsal hippocampus by sigma ligands

1 reference

12 December 2020

Effects of sigma receptor ligands on schedule-controlled behavior of rats: relation to sigma and PCP receptor binding affinity.

1 reference

12 December 2020

Identification and characterization of two sigma-like binding sites in the mouse neuroblastoma x rat glioma hybrid cell line NG108-15.

1 reference

12 December 2020

Overexpression of sigma receptors in nonneural human tumors

1 reference

12 December 2020

Lack of correlation between sigma binding potency and inhibition of contractions in the mouse vas deferens preparation

1 reference

12 December 2020

Two subtypes of enteric non-opioid sigma receptors in guinea-pig cholinergic motor neurons

1 reference

12 December 2020

Does sigma receptor antagonism predict clinical antipsychotic efficacy?

1 reference

12 December 2020

(+)-6,7-Benzomorphan sigma ligands stimulate dopamine synthesis in rat corpus striatum tissue

1 reference

12 December 2020

Effects of sigma ligands on mouse cerebellar cyclic guanosine monophosphate (cGMP) levels in vivo: further evidence for a functional modulation ofN-methyl-d-aspartate (NMDA) receptor complex-mediated events by sigma ligands

1 reference

12 December 2020

Selective sigma ligands block stimulant effects of cocaine.

1 reference

12 December 2020

Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of teprenone and cimetidine

1 reference

12 December 2020

Interactions of sigma and phencyclidine receptor ligands with the norepinephrine uptake carrier in both rat brain and rat tail artery

1 reference

12 December 2020

Sigma receptors: biology and function

1 reference

12 December 2020

Sigma and opioid receptors in human brain tumors

1 reference

12 December 2020

The sigma [corrected] ligand rimcazole antagonises (+)SKF 10,047, but not (+)3-PPP, in the mouse isolated vas deferens

1 reference

12 December 2020

GBR-12909 and fluspirilene potently inhibited binding of [3H] (+)3-PPP to sigma receptors in rat brain

1 reference

12 December 2020

Sigma receptors are highly concentrated in the rat pineal gland.

1 reference

12 December 2020

Multiple vascular effects of sigma and PCP ligands: inhibition of amine uptake and contractile responses

1 reference

12 December 2020

N-methyl-D-aspartate-induced neuronal activation is selectively modulated by sigma receptors

1 reference

12 December 2020

Effect of selective sigma ligands on duodenal alkaline secretion in the rat

1 reference

12 December 2020

Effects of KB-5492, 1-(3,4,5-trimethoxybenzyl)-4-((4-methoxyphenyl)oxycarbonylmethyl) p iperazine monofumarate monohydrate, on gastric lesions and gastric secretion in rats

1 reference

12 December 2020

High affinity dextromethorphan binding sites in guinea pig brain. Effect of sigma ligands and other agents

1 reference

12 December 2020

Autoradiographic localization of sigma opioid receptors in the gastrointestinal tract of the guinea pig.

1 reference

12 December 2020

Sigma receptors regulate contractions of the guinea pig ileum longitudinal muscle/myenteric plexus preparation elicited by both electrical stimulation and exogenous serotonin

1 reference

12 December 2020

Regulation of sigma-receptors: high- and low-affinity agonist states, GTP shifts, and up-regulation by rimcazole and 1,3-Di(2-tolyl)guanidine

1 reference

12 December 2020

Expression of (+)-3-PPP binding sites in the PC12 pheochromocytoma cell line

1 reference

12 December 2020

Electrophysiological effects of selective sigma-receptor agonists, antagonists, and the selective phencyclidine receptor agonist MK-801 on midbrain dopamine neurons

1 reference

12 December 2020

Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain

1 reference

12 December 2020

Acute and subchronic effects of Rimcazole (BW 234U), a potential antipsychotic drug, on A9 and A10 dopamine neurons in the rat.

1 reference

12 December 2020

3-Methoxytyramine accumulation: effects of typical neuroleptics and various atypical compounds.

1 reference

12 December 2020

Guinea-pig vas deferens preparation may contain both receptors and phencyclidine receptors.

1 reference

12 December 2020

Correlation of inhibitory potencies of putative antagonists for sigma receptors in brain and spleen

1 reference

12 December 2020

Activation of the A10 mesolimbic system by the sigma-receptor agonist (+)SKF 10,047 can be blocked by rimcazole, a novel putative antipsychotic

1 reference

12 December 2020

Tardive dyskinesia, dopamine receptors, and neuroleptic damage to cell membranes.

1 reference

12 December 2020

Sigma receptors on NCB-20 hybrid neurotumor cells labeled with (+)[3H]SKF 10,047 and (+)[3H]3-PPP.

1 reference

12 December 2020

Central monoamines and convulsine thresholds in mice and rats.

1 reference

12 December 2020

The pathophysiology of extrapyramidal side-effects of neuroleptic drugs

1 reference

12 December 2020

The first clinical study of BW-234U in schizophrenia

1 reference

12 December 2020

An early Phase II clinical trial of BW234U in the treatment of acute schizophrenia in newly admitted patients

1 reference

12 December 2020

(+)-N-allylnormetazocine enhances N-acetyltransferase activity and melatonin synthesis: preliminary evidence for a functional role of sigma receptors in the rat pineal gland

1 reference

12 December 2020

1,3-Di-o-tolylguanidine (DTG) differentially affects acute and tonic formalin pain: antagonism by rimcazole

1 reference

12 December 2020

The sigma receptor ligand (+/-)-BMY 14802 prevents methamphetamine-induced dopaminergic neurotoxicity via interactions at dopamine receptors.

1 reference

12 December 2020

Modulation of the PCP/NMDA receptor complex and sigma binding sites by psychostimulants.

1 reference

12 December 2020

Systemic phencyclidine administration is associated with increased dopamine, GABA, and 5-HIAA levels in the dorsolateral striatum of conscious rats: an in vivo microdialysis study

1 reference

12 December 2020

Modulation by sigma ligands of intracellular free Ca++ mobilization by N-methyl-D-aspartate in primary culture of rat frontal cortical neurons

1 reference

12 December 2020

Antinociception following 1,3,-di-o-tolylguanidine, a selective sigma receptor ligand

1 reference

12 December 2020

Pharmacological evidence for the involvement of sigma sites in DTG-induced contralateral circling in rats

1 reference

12 December 2020

DTG-induced circling behaviour in rats may involve the interaction between sigma sites and nigro-striatal dopaminergic pathways

1 reference

12 December 2020

Sigma binding site ligands inhibit cell proliferation in mammary and colon carcinoma cell lines and melanoma cells in culture

1 reference

12 December 2020

The sigma-selective ligand NE-100 attenuates the effect of phencyclidine in a rat diving model

1 reference

12 December 2020

Sigma receptor-mediated neuroprotection against glutamate toxicity in primary rat neuronal cultures

1 reference

12 December 2020

A role of sigma receptors on hypoxia/hypoglycemia-induced decrease in CA1 presynaptic fiber spikes in rat hippocampal slices.

1 reference

12 December 2020

Sigma receptors are expressed in human non-small cell lung carcinoma

1 reference

12 December 2020

Pharmacological comparison of antipsychotic drugs and sigma-antagonists in rodents.

1 reference

12 December 2020

Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines.

1 reference

12 December 2020

Effect of NE-100, a novel sigma receptor ligand, on phencyclidine-induced cognitive dysfunction

1 reference

12 December 2020

Cytotoxic effects of sigma ligands: sigma receptor-mediated alterations in cellular morphology and viability.

1 reference

12 December 2020

Cocaine-sensitive sigma-receptor and its interaction with steroid hormones in the human placental syncytiotrophoblast and in choriocarcinoma cells

1 reference

12 December 2020

Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors

1 reference

12 December 2020

Pharmacological characteristics of hyperambulation induced by the sigma ligand (+)-3-PPP in rats

1 reference

12 December 2020

The effects of sigma ligands on the release of glutamate from rat striatal slices

1 reference

12 December 2020

Characterization of specific (+)-[3H]N-allylnormetazocine and [3H]1,3-di(2-tolyl)guanidine binding sites in porcine gastric fundic mucosa

1 reference

12 December 2020

Synthesis and characterization of [125I]-N-(N-benzylpiperidin-4-yl)-4- iodobenzamide, a new sigma receptor radiopharmaceutical: high-affinity binding to MCF-7 breast tumor cells

1 reference

12 December 2020

In vitro and in vivo expression of opioid and sigma receptors in rat C6 glioma and mouse N18TG2 neuroblastoma cells

1 reference

12 December 2020

Receptor binding profiles of KB-5492, a novel anti-ulcer agent, at sigma receptors in guinea-pig brain

1 reference

12 December 2020

NPC 16377, a potent and selective sigma-ligand. II. Behavioral and neuroprotective profile.

1 reference

12 December 2020

Influence of 1,3-di-o-tolylguanidine and rimcazole, selective sigma ligands, on apomorphine and neuroleptic effects

1 reference

12 December 2020

Sigma receptor-mediated effects of a new antiulcer agent, KB-5492, on experimental gastric mucosal lesions and gastric alkaline secretion in rats

1 reference

12 December 2020

Effects of rimcazole, a specific antagonist of sigma sites, on the antitussive effects of non-narcotic antitussive drugs

1 reference

12 December 2020

Cocaine and several sigma receptor ligands inhibit dopamine uptake in rat caudate-putamen.

1 reference

12 December 2020

Effects of the selective sigma receptor ligand, 6-[6-(4-hydroxypiperidinyl)hexyloxy]-3-methylflavone (NPC 16377), on behavioral and toxic effects of cocaine

1 reference

12 December 2020

Decreased anticonvulsant activity of carbamazepine in 6-hydroxydopamine-treated rats

1 reference

12 December 2020

NPC 16377, a potent and selective sigma-ligand. I. Receptor binding, neurochemical and neuroendocrine profile.

1 reference

12 December 2020

Comparison of [3H]WIN 35,428 binding, a marker for dopamine transporter, in embryonic mesencephalic neuronal cultures with striatal membranes of adult rats.

1 reference

12 December 2020

Effects of a new sigma ligand, JO 1784, on cysteamine ulcers and duodenal alkaline secretion in rats

1 reference

12 December 2020

Correlation between potentiation of neurogenic twitch contraction and benzomorphan sigma receptor binding potency in the mouse vas deferens.

1 reference

12 December 2020

Effects of sigma receptor ligands on the extracellular concentration of dopamine in the striatum and prefrontal cortex of the rat

1 reference

12 December 2020

The sigma receptor ligand, reduced haloperidol, induces apoptosis and increases intracellular-free calcium levels [Ca2+]i in colon and mammary adenocarcinoma cells

1 reference

12 December 2020

Sigma receptor modulation of noradrenergic-stimulated pineal melatonin biosynthesis in rats

1 reference

12 December 2020

Involvement of sigma-receptors in the increase in contraction of mouse vas deferens induced by exogenous ATP

1 reference

12 December 2020

Autoradiographic visualization and pharmacological characterization of vanilloid (capsaicin) receptors in several species, including man

1 reference

12 December 2020

Interactions of selective serotonin reuptake inhibitors with subtypes of sigma receptors in rat brain

1 reference

12 December 2020

sigma Receptor antagonists block the development of sensitization to cocaine.

1 reference

12 December 2020

Binding of neuroleptic drugs (trifluoperazine and rimcazole) to vanilloid receptors in porcine dorsal horn.

1 reference

12 December 2020

Sigma 1 receptor subtype is involved in the relief of behavioral despair in the mouse forced swimming test

1 reference

12 December 2020

Synthesis, in vitro validation and in vivo pharmacokinetics of [125I]N-[2-(4-iodophenyl)ethyl]-N-methyl-2-(1-piperidinyl) ethylamine: a high-affinity ligand for imaging sigma receptor positive tumors

1 reference

12 December 2020

Sigma binding in a human neuroblastoma cell line

1 reference

12 December 2020

Neuropharmacological profile of EMD 57445, a sigma receptor ligand with potential antipsychotic activity

1 reference

12 December 2020

Sigma 2 receptors as potential biomarkers of proliferation in breast cancer

1 reference

12 December 2020

Protein phosphorylation and calcium uptake into rat forebrain synaptosomes: modulation by the sigma ligand, 1,3-ditolylguanidine.

1 reference

12 December 2020

Effects of sigma ligands on the nociceptin/orphanin FQ receptor co-expressed with the G-protein-activated K+ channel in Xenopus oocytes

1 reference

12 December 2020

Effects of sigma ligands on the ability of rimcazole to inhibit PCP hsp70 induction.

1 reference

12 December 2020

Sigma-receptor imaging by means of I123-IDAB scintigraphy: clinical application in melanoma and non-small cell lung cancer

1 reference

12 December 2020

Phencyclidine (PCP) acts at sigma sites to induce c-fos gene expression.

1 reference

12 December 2020

Role of opioidergic and serotonergic mechanisms in cough and antitussives

1 reference

12 December 2020

Nonexocytotic noradrenaline release from rat cardiac synaptosomal-mitochondrial fractions

1 reference

12 December 2020

Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole): irreversible ligands for the dopamine transporter

1 reference

12 December 2020

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog

1 reference

12 December 2020

Effect of 1,3-di-o-tolylguanidine (DTG), rimcazole and EMD 57445, the sigma receptor ligands, in the forced swimming test

1 reference

12 December 2020

Screen of receptor and uptake-site activity of hypericin component of St. John's wort reveals sigma receptor binding

1 reference

12 December 2020

Synthesis, in vitro binding, and tissue distribution of radioiodinated 2-[125I]N-(N-benzylpiperidin-4-yl)-2-iodo benzamide, 2-[125I]BP: a potential sigma receptor marker for human prostate tumors.

1 reference

12 December 2020

Increased binding to sigma sites of N-[1'(2-piperidinyl)ethyl)-4-[I-125]-iodobenzamide (I-125-PAB) with onset of tumor cell proliferation

1 reference

12 December 2020

Neuronal mechanisms of phencyclidine-induced place aversion and preference in the conditioned place preference task

1 reference

12 December 2020

Rimcazole, a sigma receptor ligand, and the anticonvulsive action of conventional antiepileptic drugs.

1 reference

12 December 2020

10.1111/J.1527-3458.2004.TB00001.X

Identifiers

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14978511%20AND%20SRC:MED&resulttype=core&format=json

24 November 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14978511%20AND%20SRC:MED&resulttype=core&format=json

24 November 2019

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