CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHC-defined rhesus macaque transplant model. (Q35675258)

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13 February 2020

title

CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHC-defined rhesus macaque transplant model (English)

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13 February 2020

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14

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13 February 2020

author name string

A Page

1

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13 February 2020

S Srinivasan

2

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13 February 2020

K Singh

3

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13 February 2020

M Russell

4

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13 February 2020

K Hamby

5

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13 February 2020

T Deane

6

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13 February 2020

S Sen

7

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L Stempora

8

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F Leopardi

9

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A A Price

10

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13 February 2020

E Strobert

11

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K A Reimann

12

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A D Kirk

13

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L S Kean

15

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language of work or name

English

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publication date

19 September 2011

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American Journal of Transplantation

13 February 2020

published in

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volume

12

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13 February 2020

page(s)

115-125

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13 February 2020

issue

1

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Specific elimination of effector memory CD4+ T cells due to enhanced Fas signaling complex formation and association with lipid raft microdomains

13 February 2020

cites work

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Cutting edge: Lymphoproliferation caused by Fas deficiency is dependent on the transcription factor eomesodermin.

12 July 2018

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An MHC-defined primate model reveals significant rejection of bone marrow after mixed chimerism induction despite full MHC matching

12 July 2018

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GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28- CD8+ T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression

12 July 2018

1 reference

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Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation

12 July 2018

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Costimulatory pathways in transplantation: challenges and new developments.

12 July 2018

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Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival.

12 July 2018

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The therapeutic potential of costimulatory blockade with CTLA4Ig in rheumatoid arthritis

12 July 2018

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A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantation

12 July 2018

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Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression.

12 July 2018

1 reference

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CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily

12 July 2018

1 reference

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CD40 plays an essential role in the activation of human B cells by murine EL4B5 cells

12 July 2018

1 reference

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Chimerism and cure: hematologic and pathologic correction of murine sickle cell disease.

12 July 2018

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CTLA4Ig: bridging the basic immunology with clinical application

21 January 2018

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Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties.

21 January 2018

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A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study).

21 January 2018

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Anti-CD40 therapy extends renal allograft survival in rhesus macaques

21 January 2018

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Microsatellite typing of the rhesus macaque MHC region

21 January 2018

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Development and homeostasis of T cell memory in rhesus macaque

21 January 2018

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Preclinical assessment of anti-CD40 Mab 5D12 in cynomolgus monkeys.

21 January 2018

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Antagonist anti-human CD40 antibody inhibits germinal center formation in cynomolgus monkeys

21 January 2018

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Costimulatory blockade in patients with rheumatoid arthritis: a pilot, dose-finding, double-blind, placebo-controlled clinical trial evaluating CTLA-4Ig and LEA29Y eighty-five days after the first infusion

21 January 2018

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Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

25 September 2018

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Induction of chimerism in rhesus macaques through stem cell transplant and costimulation blockade-based immunosuppression

21 January 2018

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12 December 2020

NK cells rapidly reject allogeneic bone marrow in the spleen through a perforin- and Ly49D-dependent, but NKG2D-independent mechanism

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A novel fully human anti-CD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeys

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Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand

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Cutting edge: administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning

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Human platelets activate porcine endothelial cells through a CD154-dependent pathway

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Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21929643%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

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13 February 2020

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