Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2. (Q35685368)

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16 January 2020

title

Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2 (English)

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16 January 2020

1

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Kateřina Levová

2

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David H. Phillips

8

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16 January 2020

Volker M. Arlt

9

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author name string

Frantisek Bárta

3

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16 January 2020

Zhanquan Shi

4

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16 January 2020

Eva Frei

5

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Heinz H Schmeiser

6

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16 January 2020

Daniel W Nebert

7

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publication date

15 November 2011

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16 January 2020

published in

Toxicological Sciences

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16 January 2020

volume

125

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16 January 2020

issue

2

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page(s)

345-358

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Role of P450 1A1 and P450 1A2 in bioactivation versus detoxication of the renal carcinogen aristolochic acid I: studies in Cyp1a1-/-, Cyp1a2-/-, and Cyp1a1/1a2-/- mice.

16 January 2020

cites work

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Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.

12 July 2018

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Gene expression changes induced by the human carcinogen aristolochic acid I in renal and hepatic tissue of mice

12 July 2018

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Cytochrome P450 1A2 detoxicates aristolochic acid in the mouse

12 July 2018

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Detoxification of aristolochic acid I by O-demethylation: less nephrotoxicity and genotoxicity of aristolochic acid Ia in rodents

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Chemical and molecular basis of the carcinogenicity of Aristolochia plants

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Aristolochic acid nephropathy: a worldwide problem

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Late onset of bladder urothelial carcinoma after kidney transplantation for end-stage aristolochic acid nephropathy: a case series with 15-year follow-up

12 July 2018

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Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy.

12 July 2018

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Aristolochic acid and the etiology of endemic (Balkan) nephropathy

12 July 2018

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Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse line

12 July 2018

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Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer.

12 July 2018

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Interspecies metabolism of heterocyclic aromatic amines and the uncertainties in extrapolation of animal toxicity data for human risk assessment

12 July 2018

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The anticancer drug ellipticine forms covalent DNA adducts, mediated by human cytochromes P450, through metabolism to 13-hydroxyellipticine and ellipticine N2-oxide

12 July 2018

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Sudan I is a potential carcinogen for humans: evidence for its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver microsomes.

12 July 2018

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Hypoxia--a key regulatory factor in tumour growth

12 July 2018

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Human enzymes involved in the metabolic activation of carcinogenic aristolochic acids: evidence for reductive activation by cytochromes P450 1A1 and 1A2

12 July 2018

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12 July 2018

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Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy.

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Human cytochromes P450 1A1 and 1A2 participate in detoxication of carcinogenic aristolochic acid.

12 July 2018

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The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen

25 September 2018

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25 September 2018

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Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer.

25 September 2018

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Identification of NQO1 and GSTs genotype frequencies in Bulgarian patients with Balkan endemic nephropathy

25 September 2018

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Human cytosolic enzymes involved in the metabolic activation of carcinogenic aristolochic acid: evidence for reductive activation by human NAD(P)H:quinone oxidoreductase.

25 September 2018

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Is aristolochic acid a risk factor for Balkan endemic nephropathy-associated urothelial cancer?

25 September 2018

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Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi)

25 September 2018

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Genetic polymorphisms of cytochrome P450 among patients with Balkan endemic nephropathy (BEN)

25 September 2018

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Crossref

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFR306

A review of human carcinogens—Part A: pharmaceuticals

21 January 2018

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Crossref

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Comparison of gene expression in cell culture to that in the intact animal: relevance to drugs and environmental toxicants. Focus on "development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense

21 January 2018

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12 December 2020

Study of the phase I and phase II metabolism of nephrotoxin aristolochic acid by liquid chromatography/tandem mass spectrometry

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12 December 2020

The 32P-postlabeling assay for DNA adducts

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12 December 2020

The human carcinogen aristolochic acid i is activated to form DNA adducts by human NAD(P)H:quinone oxidoreductase without the contribution of acetyltransferases or sulfotransferases

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12 December 2020

Identifiers

DOI

10.1093/TOXSCI/KFR306

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22086975%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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16 January 2020

PubMed publication ID

22086975

1 reference