Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis (Q35691551)

9 August 2017

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title

Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis (English)

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9 August 2017

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3

Giulio F Draetta

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9 August 2017

Luca Busino

1

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9 August 2017

Massimo Chiesa

series ordinal

2

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9 August 2017

Maddalena Donzelli

series ordinal

4

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9 August 2017

language of work or name

English

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publication date

1 March 2004

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9 August 2017

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9 August 2017

23

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9 August 2017

11

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9 August 2017

2050-2056

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1207394

9 August 2017

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cites work

Chk1 and Chk2 kinases in checkpoint control and cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

UV irradiation triggers ubiquitin-dependent degradation of p21(WAF1) to promote DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Cdc25A stability is controlled by the ubiquitin-proteasome pathway during cell cycle progression and terminal differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Role of the Cdc25A phosphatase in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Identification of a family of human F-box proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Oncogenic potential of a C.elegans cdc25 gene is demonstrated by a gain-of-function allele

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Regulating mammalian checkpoints through Cdc25 inactivation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Dual mode of degradation of Cdc25 A phosphatase

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

The cdc25 protein contains an intrinsic phosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: Evidence for multiple roles of mitotic cyclins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Cdc25 cell-cycle phosphatase as a target of c-myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

CDC25 phosphatases as potential human oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Cyclin E ablation in the mouse

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Cyclin is degraded by the ubiquitin pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Ubiquitin-dependent protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Expression of cdc25A and cdc25B proteins in thyroid neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Mitotic regulation of the APC activator proteins CDC20 and CDH1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Cdk1 is essential for mammalian cyclosome/APC regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Rapid destruction of human Cdc25A in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

The anaphase-promoting complex: proteolysis in mitosis and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Emi1 proteolysis: how SCF(beta-Trcp1) helps to activate the anaphase-promoting complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Four-dimensional control of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

The oncogenic activation of beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

cdc25+ functions as an inducer in the mitotic control of fission yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

A family of mammalian F-box proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

The DNA damage response: putting checkpoints in perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207394

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Identifiers

DOI

10.1038/SJ.ONC.1207394

1 reference

9 August 2017

1 reference