Impacts of the Glucuronidase Genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 on Tamoxifen Metabolism in Breast Cancer Patients (Q35691825)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26176234%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

title

Impacts of the Glucuronidase Genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 on Tamoxifen Metabolism in Breast Cancer Patients (English)

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19 February 2020

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Ana Fernández-Santander

5

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19 February 2020

Apolonia Novillo

2

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19 February 2020

Fernando Bandres Moya

4

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19 February 2020

author name string

Alicia Romero-Lorca

1

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19 February 2020

María Gaibar

3

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19 February 2020

language of work or name

English

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publication date

15 July 2015

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19 February 2020

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19 February 2020

volume

10

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19 February 2020

issue

7

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19 February 2020

page(s)

e0132269

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Creative Commons Attribution 4.0 International

19 February 2020

copyright license

start time

15 July 2015

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms

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Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants

27 July 2018

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Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients

27 July 2018

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CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment

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UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver

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Characterization of N-glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human liver: importance of UDP-glucuronosyltransferase 1A4

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Isolation and characterization of the human UGT2B15 gene, localized within a cluster of UGT2B genes and pseudogenes on chromosome 4.

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Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms

27 July 2018

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Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients

27 July 2018

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Evidence for oxazepam as an in vivo probe of UGT2B15: oxazepam clearance is reduced by UGT2B15 D85Y polymorphism but unaffected by UGT2B17 deletion

25 September 2018

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Genetic aspects of epitestosterone formation and androgen disposition: influence of polymorphisms in CYP17 and UGT2B enzymes

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Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism

25 September 2018

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Effect of the UGT2B15 genotype on the pharmacokinetics, pharmacodynamics, and drug interactions of intravenous lorazepam in healthy volunteers

25 September 2018

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25 September 2018

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25 September 2018

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25 September 2018

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25 September 2018

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25 September 2018

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Activity Levels of Tamoxifen Metabolites at the Estrogen Receptor and the Impact of Genetic Polymorphisms of Phase I and II Enzymes on Their Concentration Levels in Plasma

25 September 2018

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Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0132269

Functional analysis of UGT1A4(P24T) and UGT1A4(L48V) variant enzymes

21 January 2018

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12 December 2020

Comparative N-glucuronidation kinetics of ketotifen and amitriptyline by expressed human UDP-glucuronosyltransferases and liver microsomes

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12 December 2020

Genetic polymorphisms of CYP2D6 increase the risk for recurrence of breast cancer in patients receiving tamoxifen as an adjuvant therapy

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Deletions of the Androgen-MetabolizingUGT2BGenes Have an Effect on Circulating Steroid Levels and Biochemical Recurrence after Radical Prostatectomy in Localized Prostate Cancer

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Genetic variations and haplotypes of UGT1A4 in a Japanese population

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12 December 2020

Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer

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12 December 2020

Analysis of phase I and phase II metabolites of tamoxifen in breast cancer patients

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12 December 2020

Prevalence of polymorphisms in the human UDP-glucuronosyltransferase 2B family: UGT2B4(D458E), UGT2B7(H268Y), and UGT2B15(D85Y)

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12 December 2020

Distribution of 4-hydroxy-N-desmethyltamoxifen and other tamoxifen metabolites in human biological fluids during tamoxifen treatment

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12 December 2020

Glucuronidation of amine substrates by purified and expressed UDP-glucuronosyltransferase proteins

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12 December 2020

Characterization of a common deletion polymorphism of the UGT2B17 gene linked to UGT2B15

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12 December 2020

Five versus more than five years of tamoxifen therapy for breast cancer patients with negative lymph nodes and estrogen receptor-positive tumors

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12 December 2020

Androgen sulfation in healthy UDP-glucuronosyl transferase 2B17 enzyme-deficient men

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12 December 2020

Identification of 4-hydroxy-N-desmethyltamoxifen as a metabolite of tamoxifen in human bile

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12 December 2020

10.1371/JOURNAL.PONE.0132269

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26176234%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

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19 February 2020

PubMed publication ID

26176234

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