Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 CYP27A1 and CYP11A1. (Q35742601)

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scientific article published on 29 December 2011

Language	Label	Description	Also known as
English	Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 CYP27A1 and CYP11A1.	scientific article published on 29 December 2011

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scholarly article

1 reference

Europe PubMed Central

10 August 2017

Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 CYP27A1 and CYP11A1. (English)

1 reference

Europe PubMed Central

10 August 2017

4

object named as

Irina A Pikuleva

1 reference

Europe PubMed Central

10 August 2017

author name string

Gun-Young Heo

1

1 reference

Europe PubMed Central

10 August 2017

Wei-Li Liao

2

1 reference

Europe PubMed Central

10 August 2017

Illarion V Turko

3

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Europe PubMed Central

10 August 2017

language of work or name

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publication date

29 December 2011

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Europe PubMed Central

10 August 2017

number of pages

8

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inferred from page(s)

Archives of Biochemistry and Biophysics

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Europe PubMed Central

10 August 2017

518

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Europe PubMed Central

10 August 2017

2

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Europe PubMed Central

10 August 2017

119-126

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Europe PubMed Central

10 August 2017

Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

12 July 2018

Structural Basis for Three-step Sequential Catalysis by the Cholesterol Side Chain Cleavage Enzyme CYP11A1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

12 July 2018

Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

12 July 2018

Cholestenoic Acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

12 July 2018

The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

12 July 2018

Optimizing the conditions of a multiple reaction monitoring assay for membrane proteins: quantification of cytochrome P450 11A1 and adrenodoxin reductase in bovine adrenal cortex and retina

1 reference

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Cerebrotendinous xanthomatosis: an inborn error in bile acid synthesis with defined mutations but still a challenge.

1 reference

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12 July 2018

Apolipoprotein B-containing lipoproteins in retinal aging and age-related macular degeneration

1 reference

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12 July 2018

Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins

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Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease

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12 July 2018

Potential mechanisms linking cholesterol to Alzheimer's disease-like pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle

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12 July 2018

Studies of membrane topology of mitochondrial cholesterol hydroxylases CYPs 27A1 and 11A1

1 reference

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12 July 2018

Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1

1 reference

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12 July 2018

Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain

1 reference

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12 July 2018

Regulation of alpha- and beta-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the alpha-secretase pathway

1 reference

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12 July 2018

Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina

1 reference

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12 July 2018

Intraretinal lipid transport is dependent on high density lipoprotein-like particles and class B scavenger receptors

1 reference

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12 July 2018

Cytochrome P450s and cholesterol homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

12 July 2018

Expression and localization of sterol 27-hydroxylase (CYP27A1) in monkey retina

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

12 July 2018

Brain cholesterol turnover required for geranylgeraniol production and learning in mice

1 reference

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12 July 2018

The enzymes, regulation, and genetics of bile acid synthesis

1 reference

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12 July 2018

Compound heterozygous mutations in the cholesterol side-chain cleavage enzyme gene (CYP11A) cause congenital adrenal insufficiency in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

12 July 2018

Heterozygous mutation in the cholesterol side chain cleavage enzyme (p450scc) gene in a patient with 46,XY sex reversal and adrenal insufficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

12 July 2018

Cholestenoic Acid Is a Naturally Occurring Ligand for Liver X Receptor α

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

12 July 2018

The role of orphan nuclear receptors in the regulation of cholesterol homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

12 July 2018

A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

12 July 2018

cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

12 July 2018

Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

12 July 2018

Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

12 July 2018

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

12 July 2018

Sterol 27-hydroxylase: expression in human arterial endothelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

12 July 2018

Expression, purification, and enzymatic properties of recombinant human cytochrome P450c27 (CYP27).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

12 July 2018

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

12 July 2018

Regulation of intramitochondrial cholesterol transfer to side-chain cleavage cytochrome P-450 in rat adrenal gland

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

12 July 2018

Bile Acid Synthesis in Man: Metabolism of 7α-Hydroxycholesterol-14C and 26-Hydroxycholesterol-3H

1 reference

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12 July 2018

Case of cerebrotendinous xanthomatosis. I: Unusual ophthalmic features

1 reference

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12 July 2018

Cholesterol side-chain cleavage by mitochondria from the human placenta. Studies using hydroxycholesterols as substrates

1 reference

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12 July 2018

Mass spectrometric study of the enzymatic conversion of cholesterol to (22R)-22-hydroxycholesterol, (20R,22R)-20,22-dihydroxycholesterol, and pregnenolone, and of (22R)-22-hydroxycholesterol to the lgycol and pregnenolone in bovine adrenocortical pr

1 reference

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12 July 2018

Steroid binding properties of beef adrenal cortical cytochrome P-450 which catalyzes the conversion of cholesterol into pregnenolone

1 reference

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12 July 2018

Evidence that the cycloheximide-sensitive site of adrenocorticotropic hormone action is in the mitochondrion. Changes in pregnenolone formation, cholesterol content, and the electron paramagnetic resonance spectra of cytochrome P-450

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

12 July 2018

Activity-regulated cytoskeleton-associated protein in rodent brain is down-regulated by high fat diet in vivo and by 27-hydroxycholesterol in vitro

1 reference

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25 September 2018

Effect of neurosteroids on the retinal gabaergic system and electroretinographic activity in the golden hamster.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

25 September 2018

Homozygous disruption of P450 side-chain cleavage (CYP11A1) is associated with prematurity, complete 46,XY sex reversal, and severe adrenal failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

25 September 2018

Phospholipids modify substrate binding and enzyme activity of human cytochrome P450 27A1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

25 September 2018

Putative F-G loop is involved in association with the membrane in P450scc (P450 11A1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

25 September 2018

The F-G loop region of cytochrome P450scc (CYP11A1) interacts with the phospholipid membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

25 September 2018

Cerebrotendinous xanthomatosis: heterogeneity of clinical phenotype with evidence of previously undescribed ophthalmological findings.

1 reference

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25 September 2018

Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: evidence that most of this steroid in the circulation is of pulmonary origin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

25 September 2018

Electron transfer to cytochrome P-450scc limits cholesterol-side-chain-cleavage activity in the human placenta.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

25 September 2018

Ocular and systemic manifestations of cerebrotendinous xanthomatosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

25 September 2018

Elimination of cholesterol in macrophages and endothelial cells by the sterol 27-hydroxylase mechanism. Comparison with high density lipoprotein-mediated reverse cholesterol transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

15 November 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274590

15 November 2018

Polyphosphoinositide activation of cholesterol side chain cleavage with purified cytochrome P-450scc

1 reference

https://pubmed.ncbi.nlm.nih.gov/22227097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liposomal cholesterol binding to steroid-free cytochrome P450scc: effects of fatty acyl and head groups in phospholipids

1 reference

https://pubmed.ncbi.nlm.nih.gov/22227097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct expression in Escherichia coli and characterization of bovine adrenodoxins with modified amino-terminal regions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22227097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retinal age pigments generated by self-assembling lysosomotropic detergents

1 reference

https://pubmed.ncbi.nlm.nih.gov/22227097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct expression of adrenodoxin reductase in Escherichia coli and the functional characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/22227097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipids of human retina, retinal pigment epithelium, and Bruch's membrane/choroid: comparison of macular and peripheral regions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22227097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurosteroidogenesis in rat retinas

1 reference

https://pubmed.ncbi.nlm.nih.gov/22227097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Branched Phosphatidylcholines Stimulate Activity of Cytochrome P450SCC (CYP11A1) in Phospholipid Vesicles by Enhancing Cholesterol Binding, Membrane Incorporation, and Protein Exchange

1 reference

https://pubmed.ncbi.nlm.nih.gov/22227097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

27-hydroxycholesterol: production rates in normal human subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/22227097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The concentration of adrenodoxin reductase limits cytochrome p450scc activity in the human placenta

1 reference

https://pubmed.ncbi.nlm.nih.gov/22227097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct binding of cholesterol and 5beta-cholestane-3alpha,7alpha,12alpha-triol to cytochrome P450 27A1: evidence from modeling and site-directed mutagenesis studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/22227097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related Macular Degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/22227097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Cholesterol Side-Chain Cleavage System of Bovine Adrenal Cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/22227097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Participation of the membrane in the side chain cleavage of cholesterol. Reconstitution of cytochrome P-450scc into phospholipid vesicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/22227097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipid vesicle-reconstituted cytochrome P-450SCC. Mutually facilitated binding of cholesterol and adrenodoxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22227097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Colorimetric determination of phospholipids with ammonium ferrothiocyanate

1 reference

https://pubmed.ncbi.nlm.nih.gov/22227097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P-450scc-substrate interactions. Studies of binding and catalytic activity using hydroxycholesterols

1 reference

https://pubmed.ncbi.nlm.nih.gov/22227097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P-450scc-phospholipid interactions. Evidence for a cardiolipin binding site and thermodynamics of enzyme interactions with cardiolipin, cholesterol, and adrenodoxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22227097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1016/J.ABB.2011.12.016

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

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