Thrombospondin-2 influences the proportion of cartilage and bone during fracture healing. (Q35747388)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19123916%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

Thrombospondin-2 influences the proportion of cartilage and bone during fracture healing (English)

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19 January 2020

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8

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19 January 2020

author name string

Douglas K Taylor

1

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19 January 2020

Jeffrey A Meganck

2

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19 January 2020

Shawn Terkhorn

3

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19 January 2020

Rajiv Rajani

4

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19 January 2020

Amish Naik

5

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19 January 2020

Regis J O'Keefe

6

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19 January 2020

Steven A Goldstein

7

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19 January 2020

language of work or name

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1 June 2009

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Journal of Bone and Mineral Research

19 January 2020

published in

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19 January 2020

volume

24

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19 January 2020

issue

6

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19 January 2020

page(s)

1043-1054

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Thrombospondin-2 modulates extracellular matrix remodeling during physiological angiogenesis

19 January 2020

cites work

1 reference

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Thrombospondins use the VLDL receptor and a nonapoptotic pathway to inhibit cell division in microvascular endothelial cells

27 July 2018

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Prolyl-hydroxylase inhibition and HIF activation in osteoblasts promotes an adipocytic phenotype.

27 July 2018

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Hypoxia and HIF-1 alpha in chondrogenesis

27 July 2018

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Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9.

27 July 2018

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Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis

27 July 2018

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Inhibition of Cdk6 expression through p38 MAP kinase is involved in differentiation of mouse prechondrocyte ATDC5.

27 July 2018

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A network of transcriptional and signaling events is activated by FGF to induce chondrocyte growth arrest and differentiation

27 July 2018

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Megakaryocytes require thrombospondin-2 for normal platelet formation and function

27 July 2018

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Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation.

27 July 2018

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Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover

27 July 2018

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Thrombospondin 2 inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism

27 July 2018

1 reference

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Diminished callus size and cartilage synthesis in alpha 1 beta 1 integrin-deficient mice during bone fracture healing

27 July 2018

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Systemic inhibition of tumor growth and angiogenesis by thrombospondin-2 using cell-based antiangiogenic gene therapy.

27 July 2018

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Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival

27 July 2018

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Accelerated up-regulation of L-Sox5, Sox6, and Sox9 by BMP-2 gene transfer during murine fracture healing

27 July 2018

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Thrombospondins as matricellular modulators of cell function

27 July 2018

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Endogenous regulators of angiogenesis--emphasis on proteins with thrombospondin--type I motifs

27 July 2018

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Thrombospondin 2, a matricellular protein with diverse functions

27 July 2018

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The functions of thrombospondin-1 and-2.

27 July 2018

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Thrombospondin-2: a potent endogenous inhibitor of tumor growth and angiogenesis

27 July 2018

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Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human cutaneous squamous cell carcinomas

27 July 2018

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Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis

27 July 2018

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A second, expressed thrombospondin gene (Thbs2) exists in the mouse genome

27 July 2018

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HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis.

27 July 2018

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Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development.

25 September 2018

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Impaired angiogenesis, early callus formation, and late stage remodeling in fracture healing of osteopontin-deficient mice.

25 September 2018

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Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair

25 September 2018

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Mice lacking thrombospondin 2 show an atypical pattern of endocortical and periosteal bone formation in response to mechanical loading.

25 September 2018

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Expression of angiogenic factors during distraction osteogenesis

25 September 2018

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Adenoviral VEGF-A gene transfer induces angiogenesis and promotes bone formation in healing osseous tissues

25 September 2018

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Cell proliferation and apoptosis during fracture healing.

25 September 2018

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The secreted protein thrombospondin 2 is an autocrine inhibitor of marrow stromal cell proliferation.

25 September 2018

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c-Jun N-terminal kinase activation is required for the inhibition of neovascularization by thrombospondin-1.

25 September 2018

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A molecular analysis of matrix remodeling and angiogenesis during long bone development

25 September 2018

1 reference

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Accelerated wound healing in mice with a disruption of the thrombospondin 2 gene.

25 September 2018

1 reference

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Induction of hypoxia-inducible factor-1, erythropoietin, vascular endothelial growth factor, and glucose transporter-1 by hypoxia: evidence against a regulatory role for Src kinase.

25 September 2018

1 reference

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Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276350

25 September 2018

1 reference

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Increased marrow-derived osteoprogenitor cells and endosteal bone formation in mice lacking thrombospondin 2

15 November 2018

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12 December 2020

Prevention of fracture healing in rats by an inhibitor of angiogenesis

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12 December 2020

The fate of soft callus chondrocytes during long bone fracture repair

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12 December 2020

A standardized experimental fracture in the mouse tibia

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12 December 2020

Collagen and alkaline phosphatase gene expression during bone morphogenetic protein (BMP)-induced cartilage and bone differentiation

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12 December 2020

Quantification of fracture healing with three-dimensional computed tomography

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12 December 2020

The cell and molecular biology of fracture healing

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12 December 2020

Angiogenesis in fracture repair

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12 December 2020

Identifiers

DOI

10.1359/JBMR.090101

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19123916%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19123916%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

19123916

1 reference