PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers (Q35747653)

10 August 2017

title

PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers (English)

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10 August 2017

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7

1 reference

10 August 2017

Albert de la Chapelle

6

object named as

Albert de la Chapelle

0 references

Päivi Peltomäki

object named as

Päivi Peltomäki

5

0 references

Anu Loukola

2

object named as

Anu Loukola

1 reference

10 August 2017

8

Charis Eng

1 reference

10 August 2017

Xiao-Ping Zhou

1

1 reference

10 August 2017

Reijo Salovaara

3

1 reference

10 August 2017

Minna Nystrom-Lahti

4

1 reference

10 August 2017

language of work or name

English

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publication date

1 August 2002

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The American Journal of Pathology

10 August 2017

published in

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10 August 2017

volume

161

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10 August 2017

issue

2

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10 August 2017

page(s)

439-447

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PTEN gene mutations in colorectal cancers displaying microsatellite instability

10 August 2017

cites work

1 reference

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Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas

12 July 2018

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Molecular identification of latent precancers in histologically normal endometrium.

12 July 2018

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PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model

12 July 2018

1 reference

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PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

DNA mismatch repair and cancer

12 July 2018

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PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways

12 July 2018

1 reference

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Will the real Cowden syndrome please stand up: revised diagnostic criteria

12 July 2018

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Epigenetic PTEN silencing in malignant melanomas without PTEN mutation

12 July 2018

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Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis

12 July 2018

1 reference

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The multiple roles of PTEN in tumor suppression

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Microsatellite instability in adenomas as a marker for hereditary nonpolyposis colorectal cancer

12 July 2018

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Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

12 July 2018

1 reference

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Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Mutational analysis of the PTEN gene in gliomas: molecular and pathological correlations

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Allele loss in colorectal cancer at the Cowden disease/juvenile polyposis locus on 10q.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Germline mutations in PTEN are present in Bannayan-Zonana syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Microsatellite instability in cancer of the proximal colon

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Clues to the pathogenesis of familial colorectal cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Distinct PTEN mutational spectra in hereditary non-polyposis colon cancer syndrome-related endometrial carcinomas compared to sporadic microsatellite unstable tumors.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Evolution of instability at coding and non-coding repeat sequences in human MSI-H colorectal cancers.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Biallelic inactivating mutations and an occult germline mutation of PTEN in primary cervical carcinomas.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Frameshift somatic mutations in gastrointestinal cancer of the microsatellite mutator phenotype

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Incidence of Hereditary Nonpolyposis Colorectal Cancer and the Feasibility of Molecular Screening for the Disease

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850747

Association of germline mutation in the PTEN tumour suppressor gene and Proteus and Proteus-like syndromes

15 November 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964200-9

Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964200-9

Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964200-9

Mutation analysis of the PTEN/MMAC1 gene in cancers of the digestive tract

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964200-9

Microsatellite instability in the insulin–like growth factor II receptor gene in gastrointestinal tumours

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964200-9

PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964200-9

Lack of MSH2 and MSH6 characterizes endometrial but not colon carcinomas in hereditary nonpolyposis colorectal cancer

7 January 2021

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12163369

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12163369

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Exclusion of PTEN and 10q22-24 as the susceptibility locus for juvenile polyposis syndrome

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12163369

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/S0002-9440(10)64200-9

1 reference

10 August 2017

1 reference

10 August 2017

1 reference