Fulvestrant: an oestrogen receptor antagonist with a novel mechanism of action (Q35750078)

10 August 2017

1 reference

14 September 2020

Fulvestrant: an oestrogen receptor antagonist with a novel mechanism of action (English)

1 reference

10 August 2017

1 reference

14 September 2020

1 reference

17 November 2019

1 reference

17 November 2019

1 reference

14 September 2020

C K Osborne

1

1 reference

10 August 2017

A Wakeling

series ordinal

2

1 reference

10 August 2017

R I Nicholson

series ordinal

3

1 reference

10 August 2017

language of work or name

English

0 references

publication date

1 March 2004

8 references

British Journal of Cancer

10 August 2017

13 March 2019

3 April 2019

18 June 2019

17 June 2019

13 November 2019

17 November 2019

14 September 2020

8 references

10 August 2017

13 March 2019

3 April 2019

18 June 2019

17 June 2019

13 November 2019

17 November 2019

14 September 2020

90 Suppl 1

1 reference

10 August 2017

S2-6

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.bjc.6601629

10 August 2017

0 references

cites work

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Integration of signal transduction inhibitors with endocrine therapy: an approach to overcoming hormone resistance in breast cancer

12 July 2018

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Pharmacology and pharmacokinetics of the newer generation aromatase inhibitors

12 July 2018

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Nongenomic actions of steroid hormones

12 July 2018

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A phase I trial to assess the pharmacology of the new oestrogen receptor antagonist fulvestrant on the endometrium in healthy postmenopausal volunteers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Sequencing of endocrine therapies in breast cancer--integration of recent data

12 July 2018

1 reference

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Fulvestrant: a review of its development, pre-clinical and clinical data.

12 July 2018

1 reference

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The search for the ideal SERM.

12 July 2018

1 reference

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Distinct expression patterns of ER alpha and ER beta in normal human mammary gland

12 July 2018

1 reference

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Endocrine manipulation in advanced breast cancer: recent advances with SERM therapies.

12 July 2018

1 reference

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Estrogen receptor beta in breast cancer.

12 July 2018

1 reference

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Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Endocrine therapy in the treatment of metastatic breast cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Estrogen receptor transcription and transactivation: Estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer

12 July 2018

1 reference

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Estrogen receptors: selective ligands, partners, and distinctive pharmacology

12 July 2018

1 reference

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12 July 2018

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Randomized trial of diethylstilbestrol vs. tamoxifen in postmenopausal women with metastatic breast cancer. An updated analysis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Basic guide to the mechanisms of antiestrogen action

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Tamoxifen for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Nuclear receptor coactivators and corepressors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Cloning of a novel receptor expressed in rat prostate and ovary

12 July 2018

1 reference

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Estradiol increases and anti-estrogens antagonize the growth factor-induced activator protein-1 activity in MCF7 breast cancer cells without affecting c-fos and c-jun synthesis

12 July 2018

1 reference

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Circumvention of tamoxifen resistance by the pure anti-estrogen ICI 182,780.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Altered expression of estrogen-regulated genes in a tamoxifen-resistant and ICI 164,384 and ICI 182,780 sensitive human breast cancer cell line, MCF-7/TAMR-1.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Molecular mechanisms of action of steroid/thyroid receptor superfamily members

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Use of pure antioestrogens to elucidate the mode of action of oestrogens

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Human breast cancer cell lines resistant to pure anti-estrogens are sensitive to tamoxifen treatment

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Responses to pure antiestrogens (ICI 164384, ICI 182780) in estrogen-sensitive and -resistant experimental and clinical breast cancer.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Gene regulation by steroid hormones

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Inhibition of estrogen receptor-DNA binding by the "pure" antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

A potent specific pure antiestrogen with clinical potential

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Estrogen receptor in human breast cancer in relation to tumor morphology and endocrine therapy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Steroid receptors study in breast carcinoma

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Development of cDNA microarray for expression profiling of estrogen-responsive genes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Fulvestrant, an estrogen receptor downregulator, reduces cell turnover index more effectively than tamoxifen.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Rapid nongenomic E2 effects on p42/p44 MAPK, activator protein-1, and cAMP response element binding protein in rat white adipocytes

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Comparison of the short-term biological effects of 7alpha-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)-nonyl]estra-1,3,5, (10)-triene-3,17beta-diol (Faslodex) versus tamoxifen in postmenopausal women with primary breast cancer.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Comparison of the effects of a pure steroidal antiestrogen with those of tamoxifen in a model of human breast cancer.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Investigation of a new pure antiestrogen (ICI 182780) in women with primary breast cancer

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750773

Some comments on the necessity of receptor determination in human breast cancer

15 November 2018

1 reference

12 December 2020

Steroidal pure antioestrogens

1 reference

12 December 2020

Functional domains of the human estrogen receptor

1 reference

12 December 2020

Novel antioestrogens without partial agonist activity

1 reference

12 December 2020

Antiuterotrophic effects of a pure antioestrogen, ICI 182,780: magnetic resonance imaging of the uterus in ovariectomized monkeys

1 reference

12 December 2020

The importance of tamoxifen metabolism in tamoxifen-stimulated breast tumor growth

1 reference

12 December 2020

Short-term effects of pure anti-oestrogen ICI 182780 treatment on oestrogen receptor, epidermal growth factor receptor and transforming growth factor-alpha protein expression in human breast cancer

1 reference

12 December 2020

Effects of short-term antiestrogen treatment of primary breast cancer on estrogen receptor mRNA and protein expression and on estrogen-regulated genes

1 reference

12 December 2020

Megestrol acetate in advanced breast carcinoma

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.BJC.6601629

1 reference

10 August 2017

1 reference

10 August 2017

1 reference