An essential role for protein synthesis in oncogenic cellular transformation (Q35750105)

10 August 2017

1 reference

title

An essential role for protein synthesis in oncogenic cellular transformation (English)

1 reference

10 August 2017

Peter K Vogt

2

0 references

author name string

Andreas G Bader

series ordinal

1

1 reference

PubMed ID

15094764

10 August 2017

language of work or name

English

0 references

publication date

1 April 2004

1 reference

10 August 2017

1 reference

10 August 2017

23

1 reference

10 August 2017

18

1 reference

10 August 2017

3145-3150

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.onc.1207550

10 August 2017

0 references

cites work

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

The akt kinase: molecular determinants of oncogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

The catalytic subunit of phosphoinositide 3-kinase: requirements for oncogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

Y box-binding protein 1 induces resistance to oncogenic transformation by the phosphatidylinositol 3-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

Translational control: the cancer connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

eIF4E expression in tumors: its possible role in progression of malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

Ribosomal S6 kinase signaling and the control of translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

Translational regulation by Y-box transcription factor: involvement of the major mRNA-associated protein, p50.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

Immunophilins: beyond immunosuppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

Glomerular mesangial cell-specific transactivation of matrix metalloproteinase 2 transcription is mediated by YB-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

Isolation of DNA sequences amplified at chromosome 19q13.1-q13.2 including the AKT2 locus in human pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

The mRNA-binding protein YB-1 (p50) prevents association of the eukaryotic initiation factor eIF4G with mRNA and inhibits protein synthesis at the initiation stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

eIF4E activity is regulated at multiple levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

PKB/AKT: functional insights from genetic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

PTEN: life as a tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

The mRNA 5' cap-binding protein eIF4E and control of cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

YB-1 DNA-binding protein represses interferon gamma activation of class II major histocompatibility complex genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

Characterization of the association of specific proteins with messenger ribonucleic acid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

The phosphoinositide 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

Regulation of cell death protease caspase-9 by phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

DNA double strand break repair and chromosomal translocation: lessons from animal models

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

Direct control of the Forkhead transcription factor AFX by protein kinase B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

PIK3CA as an oncogene in cervical cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

Role of cytoplasmic mRNP proteins in translation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

Advantages and limitations of microarray technology in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

TOR, a central controller of cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

Nuclear localization of Y-box factor YB1 requires wild-type p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

Phosphorylation and regulation of Raf by Akt (protein kinase B)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207550

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207550

1 reference

10 August 2017

1 reference

PubMed ID

15094764