Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms. Role for p53-independent induction of gadd-45 in initiating death. (Q35764522)

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scientific article published on October 1995

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English	Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms. Role for p53-independent induction of gadd-45 in initiating death.	scientific article published on October 1995

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scholarly article

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20 October 2019

Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms. Role for p53-independent induction of gadd-45 in initiating death (English)

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20 October 2019

Peter Joseph Jacques Parker

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20 October 2019

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J E de Vente

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20 October 2019

C A Kukoly

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20 October 2019

W O Bryant

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20 October 2019

K J Posekany

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20 October 2019

J Chen

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20 October 2019

D J Fletcher

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20 October 2019

G J Pettit

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20 October 2019

G Lozano

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20 October 2019

P P Cook

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20 October 2019

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1 October 1995

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20 October 2019

Journal of Clinical Investigation

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20 October 2019

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20 October 2019

1874-1886

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20 October 2019

4

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20 October 2019

Protein kinase C isoenzymes: divergence in signal transduction?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=185824

2 October 2017

p53 is required for radiation-induced apoptosis in mouse thymocytes

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A phase I study of intravenous bryostatin 1 in patients with advanced cancer

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Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1 reference

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2 October 2017

WAF1, a potential mediator of p53 tumor suppression

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Phase I study of bryostatin 1: assessment of interleukin 6 and tumor necrosis factor alpha induction in vivo. The Cancer Research Campaign Phase I Committee

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2 October 2017

Analysis of the mammalian gadd45 gene and its response to DNA damage

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Molecular controls of apoptosis: differentiation/growth arrest primary response genes, proto-oncogenes, and tumor suppressor genes as positive & negative modulators

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2 October 2017

Effects of chronic phorbol ester treatment on protein kinase C activity, content, and gene expression in the human monoblastoid U937 cell.

1 reference

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2 October 2017

Protein kinase C--a question of specificity

1 reference

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2 October 2017

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth

1 reference

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Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53.

1 reference

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2 October 2017

Phorbol ester treatment of U937 cells with altered protein kinase C content and distribution induces cell death rather than differentiation.

1 reference

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2 October 2017

MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype

1 reference

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2 October 2017

Cell death: the significance of apoptosis

1 reference

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2 October 2017

Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin

1 reference

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2 October 2017

Inhibition of MCF-7 cell growth by 12-O-tetradecanoylphorbol-13-acetate and 1,2-dioctanoyl-sn-glycerol: distinct effects on protein kinase C activity

1 reference

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2 October 2017

Effects of activators of protein kinase C, including bryostatins 1 and 2, on the growth of A549 human lung carcinoma cells

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Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C

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2 October 2017

Participation of p53 protein in the cellular response to DNA damage

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A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

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2 October 2017

Elevated level of nuclear protein kinase C in multidrug-resistant MCF-7 human breast carcinoma cells

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Mammalian genes induced by radiation; activation of genes associated with growth control.

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Genotoxic-stress-response genes and growth-arrest genes. gadd, MyD, and other genes induced by treatments eliciting growth arrest

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

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Features of apoptotic cells measured by flow cytometry

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Epstein-Barr virus infection is associated with increased apoptosis in untreated and phorbol ester-treated human Burkitt's lymphoma (AW-Ramos) cells

1 reference

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1 reference

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Tumor-promoting phorbol ester transiently down-modulates the p53 level and blocks the cell cycle

1 reference

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12 July 2018

Induction of WAF1/CIP1 by a p53-independent pathway

1 reference

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1 reference

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Influence of 12-O-tetradecanoylphorbol-13-acetate on proliferation and maturation of human breast carcinoma cells (MCF-7): relationship to cell cycle events.

1 reference

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Hyperinducible gene expression from a metallothionein promoter containing additional metal-responsive elements

1 reference

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12 July 2018

Role of protein kinase C in the inhibition by fibroblast growth factor of apoptosis in serum-depleted endothelial cells.

1 reference

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12 July 2018

Differential effects of bryostatin 1 and phorbol ester on human breast cancer cell lines.

1 reference

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12 July 2018

Acquisition of a growth-inhibitory response to phorbol ester involves DNA damage

1 reference

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12 July 2018

Thymocyte apoptosis induced by p53-dependent and independent pathways.

1 reference

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1 reference

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23 October 2018

Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/7560079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/7560079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptosis in chronic lymphocytic leukemia cells and its prevention by phorbol ester

1 reference

https://pubmed.ncbi.nlm.nih.gov/7560079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of phorbol ester-induced T cell proliferation by bryostatin is associated with rapid degradation of protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/7560079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of p21 (WAF-1/CIP1) during differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7560079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C desensitization by phorbol esters and its impact on growth of human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7560079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differing modulation of protein kinase C by bryostatin 1 and phorbol esters in JB6 mouse epidermal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7560079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7560079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/7560079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI118233

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20 October 2019

1 reference

Europe PubMed Central

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20 October 2019

1 reference

Europe PubMed Central

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20 October 2019

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