The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis (Q35764862)

10 August 2017

title

The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis (English)

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10 August 2017

1 reference

Maarten Van Roy

1

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10 August 2017

Cedric Ververken

2

1 reference

10 August 2017

Els Beirnaert

3

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10 August 2017

Sven Hoefman

4

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10 August 2017

Joost Kolkman

5

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10 August 2017

Michel Vierboom

6

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10 August 2017

Elia Breedveld

7

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10 August 2017

Bert 't Hart

8

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10 August 2017

Sofie Poelmans

9

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10 August 2017

Lieselot Bontinck

10

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10 August 2017

Alex Hemeryck

11

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10 August 2017

Sandy Jacobs

12

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10 August 2017

Judith Baumeister

13

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10 August 2017

Hans Ulrichts

14

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10 August 2017

publication date

20 May 2015

1 reference

Arthritis Research and Therapy

10 August 2017

published in

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10 August 2017

volume

17

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10 August 2017

page(s)

135

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Creative Commons Attribution 4.0 International

10 August 2017

copyright license

start time

20 May 2015

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April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Interleukin-6 upregulates expression of ADAMTS-4 in fibroblast-like synoviocytes from patients with rheumatoid arthritis.

25 September 2018

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Population pharmacokinetic analysis of tocilizumab in patients with rheumatoid arthritis.

25 September 2018

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Tocilizumab, a humanized anti-interleukin-6 receptor antibody, ameliorates joint swelling in established monkey collagen-induced arthritis.

25 September 2018

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25 September 2018

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25 September 2018

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25 September 2018

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Collagen-induced arthritis in rhesus monkeys: evaluation of markers for inflammation and joint degradation.

25 September 2018

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Collagen-induced arthritis in nonhuman primates: multiple epitopes of type II collagen can induce autoimmune-mediated arthritis in outbred cynomolgus monkeys.

25 September 2018

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25 September 2018

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25 September 2018

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12 December 2020

Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease

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12 December 2020

Physiological parameters in laboratory animals and humans

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12 December 2020

Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys

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12 December 2020

Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate

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12 December 2020

Sex-linked differences in susceptibility of cynomolgus monkeys to type II collagen-induced arthritis. Evidence that epitope-specific immune suppression is involved in the regulation of type II collagen autoantibody formation

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12 December 2020

10.1186/S13075-015-0651-0

Identifiers

DOI

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Dimensions Publication ID

10 August 2017

1051886960

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Fatcat ID

release_duwciolr5beavn2s5vhwgfqal4

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Fatcat

https://api.fatcat.wiki/v0/release/duwciolr5beavn2s5vhwgfqal4

24 November 2022

mapped directly with Wikidata item

PMC publication ID

4476083

1 reference

10 August 2017

1 reference