The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis (Q35764862)

10 August 2017

The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis (English)

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10 August 2017

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Maarten Van Roy

1

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10 August 2017

Cedric Ververken

2

1 reference

10 August 2017

Els Beirnaert

3

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10 August 2017

Sven Hoefman

4

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10 August 2017

Joost Kolkman

5

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10 August 2017

Michel Vierboom

6

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10 August 2017

Elia Breedveld

7

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10 August 2017

Bert 't Hart

8

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10 August 2017

Sofie Poelmans

9

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10 August 2017

Lieselot Bontinck

10

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10 August 2017

Alex Hemeryck

11

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10 August 2017

Sandy Jacobs

12

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10 August 2017

Judith Baumeister

13

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10 August 2017

Hans Ulrichts

14

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10 August 2017

20 May 2015

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Arthritis Research and Therapy

10 August 2017

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10 August 2017

17

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10 August 2017

135

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Creative Commons Attribution 4.0 International

10 August 2017

start time

20 May 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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exact match

https://scigraph.springernature.com/pub.10.1186/s13075-015-0651-0

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cites work

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Interleukin 6 and rheumatoid arthritis

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PDL241, a novel humanized monoclonal antibody, reveals CD319 as a therapeutic target for rheumatoid arthritis

2 October 2017

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Novel therapy based on camelid nanobodies

2 October 2017

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Nanobodies: natural single-domain antibodies

2 October 2017

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The significance of non-human primates as preclinical models of human arthritic disease

2 October 2017

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Consensus statement on blocking the effects of interleukin-6 and in particular by interleukin-6 receptor inhibition in rheumatoid arthritis and other inflammatory conditions

2 October 2017

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Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis

2 October 2017

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Current understanding of rheumatoid arthritis therapy

2 October 2017

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The roles of interleukin-6 in the pathogenesis of rheumatoid arthritis

2 October 2017

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The pro- and anti-inflammatory properties of the cytokine interleukin-6.

2 October 2017

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XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1β-mediated diseases

2 October 2017

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Neonatal Fc receptor: from immunity to therapeutics

2 October 2017

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Interleukin-1β and interleukin-6 in arthritis animal models: roles in the early phase of transition from acute to chronic inflammation and relevance for human rheumatoid arthritis

2 October 2017

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EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs

2 October 2017

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Treating rheumatoid arthritis to target: recommendations of an international task force

2 October 2017

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2 October 2017

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Evidence-based review of biologic markers as indicators of disease progression and remission in rheumatoid arthritis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476083

Preclinical models of arthritic disease in non-human primates.

2 October 2017

1 reference

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Modeling human arthritic diseases in nonhuman primates.

2 October 2017

1 reference

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Unparalleled complexity of the MHC class I region in rhesus macaques

2 October 2017

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Antibody pharmacokinetics and pharmacodynamics

2 October 2017

1 reference

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Crystal structural analysis of human serum albumin complexed with hemin and fatty acid

2 October 2017

1 reference

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Prophylactic and therapeutic effects of a humanized monoclonal antibody against the IL-2 receptor (DACLIZUMAB) on collagen-induced arthritis (CIA) in rhesus monkeys

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476083

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476083

Interleukin-6 and the acute phase response

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476083

Resistance to collagen-induced arthritis in a nonhuman primate species maps to the major histocompatibility complex class I region

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476083

The structural and molecular basis of glomerular filtration

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476083

Primary structure of a human IgA1 immunoglobulin. IV. Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476083

Nanobodies and their potential applications

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476083

Interleukin-6 upregulates expression of ADAMTS-4 in fibroblast-like synoviocytes from patients with rheumatoid arthritis.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476083

Population pharmacokinetic analysis of tocilizumab in patients with rheumatoid arthritis.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476083

Tocilizumab, a humanized anti-interleukin-6 receptor antibody, ameliorates joint swelling in established monkey collagen-induced arthritis.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476083

The pharmacokinetics of an albumin-binding Fab (AB.Fab) can be modulated as a function of affinity for albumin.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476083

Demonstration of an in vivo generated sub-picomolar affinity fully human monoclonal antibody to interleukin-8.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476083

In vivo blocking effects of a humanized antibody to human interleukin-6 receptor on interleukin-6 function in primates.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476083

Collagen-induced arthritis in rhesus monkeys: evaluation of markers for inflammation and joint degradation.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476083

Collagen-induced arthritis in nonhuman primates: multiple epitopes of type II collagen can induce autoimmune-mediated arthritis in outbred cynomolgus monkeys.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476083

Long-acting growth hormones produced by conjugation with polyethylene glycol.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476083

Reduced immunogenicity and improved pharmacokinetics of humanized anti-Tac in cynomolgus monkeys

25 September 2018

1 reference

12 December 2020

Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease

1 reference

12 December 2020

Physiological parameters in laboratory animals and humans

1 reference

12 December 2020

Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys

1 reference

12 December 2020

Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate

1 reference

12 December 2020

Sex-linked differences in susceptibility of cynomolgus monkeys to type II collagen-induced arthritis. Evidence that epitope-specific immune suppression is involved in the regulation of type II collagen autoantibody formation

1 reference

12 December 2020

10.1186/S13075-015-0651-0

Identifiers

DOI

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Dimensions Publication ID

10 August 2017

1051886960

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Fatcat ID

release_duwciolr5beavn2s5vhwgfqal4

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https://api.fatcat.wiki/v0/release/duwciolr5beavn2s5vhwgfqal4

24 November 2022

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PMCID

4476083

1 reference

10 August 2017

1 reference