Merlin and the ERM proteins in Schwann cells, neurons and growth cones (Q35777641)

10 August 2017

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title

Merlin and the ERM proteins in Schwann cells, neurons and growth cones (English)

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10 August 2017

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Vijaya Ramesh

1

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PubMed ID

15152196

10 August 2017

language of work or name

English

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publication date

1 June 2004

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Nature Reviews Neuroscience

10 August 2017

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10 August 2017

5

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10 August 2017

6

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10 August 2017

462-470

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https://scigraph.springernature.com/pub.10.1038/nrn1407

10 August 2017

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cites work

ERM-Merlin and EBP50 protein families in plasma membrane organization and function

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ERM proteins and merlin: integrators at the cell cortex

21 January 2018

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Purification of an 80,000-dalton protein that is a component of the isolated microvillus cytoskeleton, and its localization in nonmuscle cells

21 January 2018

1 reference

The protein-tyrosine kinase substrate, p81, is homologous to a chicken microvillar core protein

21 January 2018

1 reference

Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells

21 January 2018

1 reference

A new 82-kD barbed end-capping protein (radixin) localized in the cell-to-cell adherens junction: purification and characterization

21 January 2018

1 reference

Radixin is a component of hepatocyte microvilli in situ

21 January 2018

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Molecular dissection of radixin: distinct and interdependent functions of the amino- and carboxy-terminal domains

21 January 2018

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Radixin, a barbed end-capping actin-modulating protein, is concentrated at the cleavage furrow during cytokinesis

21 January 2018

1 reference

Subcellular localization of moesin in dynamic filopodia, retraction fibers, and other structures involved in substrate exploration, attachment, and cell-cell contacts

21 January 2018

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The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane

21 January 2018

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Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain

21 January 2018

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A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.

21 January 2018

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Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

21 January 2018

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Merlin: the neurofibromatosis 2 tumor suppressor

21 January 2018

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Merlin and ERM proteins: unappreciated roles in cancer development?

21 January 2018

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ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons

21 January 2018

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Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family

21 January 2018

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NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins

21 January 2018

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NHE3 kinase A regulatory protein E3KARP binds the epithelial brush border Na+/H+ exchanger NHE3 and the cytoskeletal protein ezrin

21 January 2018

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The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange

21 January 2018

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A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins

21 January 2018

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Assembly of signaling complexes by the sodium-hydrogen exchanger regulatory factor family of PDZ-containing proteins

21 January 2018

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Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation

21 January 2018

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Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis.

21 January 2018

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Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association

21 January 2018

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Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway

21 January 2018

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Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate

21 January 2018

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Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes

21 January 2018

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Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases

21 January 2018

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Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility

21 January 2018

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Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein

21 January 2018

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The carboxyl-terminal region of EBP50 binds to a site in the amino-terminal domain of ezrin that is masked in the dormant molecule.

21 January 2018

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Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain

21 January 2018

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Hierarchy of merlin and ezrin N- and C-terminal domain interactions in homo- and heterotypic associations and their relationship to binding of scaffolding proteins EBP50 and E3KARP.

21 January 2018

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The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

21 January 2018

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Effect of merlin phosphorylation on neurofibromatosis 2 (NF2) gene function.

21 January 2018

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Structural analysis of Drosophila merlin reveals functional domains important for growth control and subcellular localization

21 January 2018

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Merlin links to the cAMP neuronal signaling pathway by anchoring the RIbeta subunit of protein kinase A.

21 January 2018

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Ezrin and moesin expression within the developing human cerebrum and tuberous sclerosis-associated cortical tubers

21 January 2018

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Polarized domains of myelinated axons.

21 January 2018

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The local differentiation of myelinated axons at nodes of Ranvier

21 January 2018

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Nodes of Ranvier form in association with ezrin-radixin-moesin (ERM)-positive Schwann cell processes

21 January 2018

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Ezrin, radixin, and moesin are components of Schwann cell microvilli

21 January 2018

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Local ERM activation and dynamic growth cones at Schwann cell tips implicated in efficient formation of nodes of Ranvier

21 January 2018

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Association of Caspr/paranodin with tumour suppressor schwannomin/merlin and beta1 integrin in the central nervous system

21 January 2018

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Familial schwannomatosis: exclusion of the NF2 locus as the germline event

21 January 2018

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Loss of merlin expression in sporadic meningiomas, ependymomas and schwannomas.

21 January 2018

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Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse

21 January 2018

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Isolation and characterization of Schwann cells from neurofibromatosis type 2 patients

21 January 2018

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Ruffling membrane, stress fiber, cell spreading and proliferation abnormalities in human Schwannoma cells

21 January 2018

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The neurofibromatosis type 2 gene product, merlin, reverses the F-actin cytoskeletal defects in primary human Schwannoma cells

21 January 2018

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Regulation of the neurofibromatosis type 2 tumor suppressor protein, merlin, by adhesion and growth arrest stimuli

21 January 2018

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Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization

21 January 2018

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p21-activated kinase links Rac/Cdc42 signaling to merlin

21 January 2018

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Merlin, the Product of the Nf2 Tumor Suppressor Gene, Is an Inhibitor of the p21-Activated Kinase, Pak1

21 January 2018

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NF2deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions

21 January 2018

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Cloning and characterization of SCHIP-1, a novel protein interacting specifically with spliced isoforms and naturally occurring mutant NF2 proteins

21 January 2018

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The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate

21 January 2018

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Schwannomin isoform-1 interacts with syntenin via PDZ domains

21 January 2018

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The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44

21 January 2018

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Merlin, the neurofibromatosis type 2 gene product, and beta1 integrin associate in isolated and differentiating Schwann cells

21 January 2018

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Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology

21 January 2018

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Cytoskeletal Dynamics and Transport in Growth Cone Motility and Axon Guidance

21 January 2018

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The role of cytoskeleton in organizing growth cones: a microfilament-associated growth cone component depends upon microtubules for its localization

21 January 2018

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Suppression of radixin and moesin alters growth cone morphology, motility, and process formation in primary cultured neurons

21 January 2018

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Radixin is involved in lamellipodial stability during nerve growth cone motility

21 January 2018

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Migration of nerve growth cones requires detergent-resistant membranes in a spatially defined and substrate-dependent manner.

21 January 2018

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Functional binding interaction identified between the axonal CAM L1 and members of the ERM family

21 January 2018

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Identification and characterization of the tuberous sclerosis gene on chromosome 16

21 January 2018

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Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

21 January 2018

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The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

21 January 2018

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The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton

21 January 2018

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Pam and Its Ortholog Highwire Interact with and May Negatively Regulate the TSC1·TSC2 Complex

21 January 2018

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The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis

21 January 2018

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21 January 2018

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RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts

21 January 2018

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Rho- and rac-dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts: an essential role for ezrin/radixin/moesin proteins

21 January 2018

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Signalling mechanisms mediating neuronal responses to guidance cues

21 January 2018

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Protein synthesis at synaptic sites on dendrites

21 January 2018

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Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation

21 January 2018

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Adaptation in the chemotactic guidance of nerve growth cones

21 January 2018

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Axonal protein synthesis provides a mechanism for localized regulation at an intermediate target

21 January 2018

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Organization and translation of mRNA in sympathetic axons

21 January 2018

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Microvillus-specific Mr 75,000 plasma membrane protein of human choriocarcinoma cells

21 January 2018

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Moesin: a member of the protein 4.1-talin-ezrin family of proteins

31 March 2020

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Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins

31 March 2020

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Protein kinase C-theta phosphorylation of moesin in the actin-binding sequence

31 March 2020

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Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures

31 March 2020

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The 2.7 A crystal structure of the activated FERM domain of moesin: an analysis of structural changes on activation

31 March 2020

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Interdomain binding mediates tumor growth suppression by the NF2 gene product

31 March 2020

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Interdomain interaction of merlin isoforms and its influence on intermolecular binding to NHE-RF

31 March 2020

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Merlin differentially associates with the microtubule and actin cytoskeleton

31 March 2020

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Neurofibromatosis 2 tumour suppressor schwannomin interacts with betaII-spectrin

31 March 2020

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Expression of NF2-encoded merlin and related ERM family proteins in the human central nervous system

31 March 2020

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Peripheral astrocyte processes: monitoring by selective immunostaining for the actin-binding ERM proteins

31 March 2020

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Three-dimensional fine structure of cytoskeletal-membrane interactions at nodes of Ranvier

31 March 2020

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Co-localization of the myelin-associated glycoprotein and the microfilament components, F-actin and spectrin, in Schwann cells of myelinated nerve fibres

31 March 2020

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Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

31 March 2020

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Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein

31 March 2020

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Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cells

31 March 2020

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Association of ezrin isoforms with the neuronal cytoskeleton

31 March 2020

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Response of radixin to perturbations of growth cone morphology and motility in chick sympathetic neurons in vitro

31 March 2020

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The establishment of polarity by hippocampal neurons in culture

31 March 2020

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Neuronal polarity: vectorial cytoplasmic flow precedes axon formation.

31 March 2020

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Nerve growth factor-inducible large external (NILE) glycoprotein: studies of a central and peripheral neuronal marker

31 March 2020

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Highwire regulates synaptic growth in Drosophila

31 March 2020

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rpm-1, a conserved neuronal gene that regulates targeting and synaptogenesis in C. elegans

31 March 2020

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Regulation of presynaptic terminal organization by C. elegans RPM-1, a putative guanine nucleotide exchanger with a RING-H2 finger domain

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRN1407

1 reference

PubMed ID

15152196

Dimensions Publication ID

10 August 2017

0 references

1 reference

PubMed ID

15152196