Dimeric Eg5 maintains processivity through alternating-site catalysis with rate-limiting ATP hydrolysis (Q35785839)

10 August 2017

Dimeric Eg5 maintains processivity through alternating-site catalysis with rate-limiting ATP hydrolysis (English)

1 reference

10 August 2017

Troy C Krzysiak

1

1 reference

PubMed ID

17062577

10 August 2017

Susan P Gilbert

series ordinal

2

1 reference

PubMed ID

17062577

10 August 2017

language of work or name

English

0 references

publication date

23 October 2006

1 reference

Journal of Biological Chemistry

10 August 2017

1 reference

10 August 2017

281

1 reference

10 August 2017

51

1 reference

10 August 2017

39444-39454

1 reference

Pathway of ATP hydrolysis by monomeric kinesin Eg5

10 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Phenothiazine and carbazole-related compounds inhibit mitotic kinesin Eg5 and trigger apoptosis in transformed culture cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

A structural model for monastrol inhibition of dimeric kinesin Eg5.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

ATPase mechanism of Eg5 in the absence of microtubules: insight into microtubule activation and allosteric inhibition by monastrol

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

A unique ATP hydrolysis mechanism of single-headed processive myosin, myosin IX

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Kinetic mechanism of myosin IXB and the contributions of two class IX-specific regions

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Monastrol inhibition of the mitotic kinesin Eg5.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

The rate of bipolar spindle assembly depends on the microtubule-gliding velocity of the mitotic kinesin Eg5.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Mechanistic analysis of the mitotic kinesin Eg5.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Antitumor activity of a kinesin inhibitor

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

12 July 2018

Kinesin's second step

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

A mechanistic model for the organization of microtubule asters by motor and non-motor proteins in a mammalian mitotic extract.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Kinetics: a tool to study molecular motors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Expanding the role of HsEg5 within the mitotic and post-mitotic phases of the cell cycle.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Kinetics and motility of the Eg5 microtubule motor

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Evidence for alternating head catalysis by kinesin during microtubule-stimulated ATP hydrolysis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Direct, real-time measurement of rapid inorganic phosphate release using a novel fluorescent probe and its application to actomyosin subfragment 1 ATPase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Pathway of processive ATP hydrolysis by kinesin.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Mitotic spindle organization by a plus-end-directed microtubule motor

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1866285

Eg5 causes elongation of meiotic spindles when flux-associated microtubule depolymerization is blocked.

12 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608056200

A novel action of terpendole E on the motor activity of mitotic Kinesin Eg5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608056200

Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608056200

Synthesis and biological evaluation of novel EG5 inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608056200

Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608056200

Monastrol stabilises an attached low-friction mode of Eg5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608056200

A pathway of structural changes produced by monastrol binding to Eg5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608056200

Docking and rolling, a model of how the mitotic motor Eg5 works

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608056200

Alternating site mechanism of the kinesin ATPase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608056200

Motor domain mutation traps kinesin as a microtubule rigor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608056200

Analysis of numerical methods for computer simulation of kinetic processes: development of KINSIM--a flexible, portable system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608056200

The ATPase cross-bridge cycle of the Kar3 motor domain. Implications for single head motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608056200

Interacting head mechanism of microtubule-kinesin ATPase

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17062577

12 December 2020

inferred from PubMed ID database lookup

Pathway of ATP hydrolysis by monomeric and dimeric kinesin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17062577

12 December 2020

inferred from PubMed ID database lookup

All-trans-retinoic acid-mediated growth inhibition involves inhibition of human kinesin-related protein HsEg5

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17062577

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M608056200

1 reference

release_qrixfrt4pvhonbgqpclchdfcjy

10 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/qrixfrt4pvhonbgqpclchdfcjy

24 November 2022

mapped directly with Wikidata item

PMCID

1866285

1 reference

10 August 2017

1 reference

PubMed ID

17062577