Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs (Q35789021)

10 August 2017

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title

Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs (English)

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10 August 2017

Jean-Pierre Valentin

1

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10 August 2017

Peter Hoffmann

2

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10 August 2017

Fred De Clerck

3

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10 August 2017

Tim G Hammond

4

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10 August 2017

Luc Hondeghem

5

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10 August 2017

1 May 2004

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Journal of Pharmacological and Toxicological Methods

10 August 2017

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10 August 2017

49

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10 August 2017

3

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10 August 2017

171-181

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Sex differences in ventricular repolarization: from cardiac electrophysiology to Torsades de Pointes

10 August 2017

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Assessing predictors of drug-induced torsade de pointes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Female gender as a risk factor for drug-induced cardiac arrhythmias: evaluation of clinical and experimental evidence.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

On a newly proposed in vitro proarrhythmia model

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: clinical and regulatory implications. Report on a Policy Conference of the European Society of Cardiology.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Amiodarone-associated proarrhythmic effects. A review with special reference to torsade de pointes tachycardia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Computer aided development of antiarrhythmic agents with class IIIa properties

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Phase 2 prolongation, in the absence of instability and triangulation, antagonizes class III proarrhythmia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Blinded test in isolated female rabbit heart reliably identifies action potential duration prolongation and proarrhythmic drugs: importance of triangulation, reverse use dependence, and instability

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Triggered activity in the heart: cellular mechanisms of early after-depolarizations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Cardiac ventricular automaticity induced by current of injury

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Molecular basis of the delayed rectifier current I(ks)in heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

QT prolongation and Torsades de Pointes associated with clarithromycin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Inward rectifiers in the heart: an update on I(K1).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Female gender is a risk factor for drug-induced long QT and cardiac arrhythmias in an in vivo rabbit model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Amiodarone blocks inactivated cardiac sodium channels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Block of inactivated sodium channels and of depolarization-induced automaticity in guinea pig papillary muscle by amiodarone

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Divergent proarrhythmic potential of macrolide antibiotics despite similar QT prolongation: fast phase 3 repolarization prevents early afterdepolarizations and torsade de pointes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

The molecular and ionic specificity of antiarrhythmic drug actions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Concordance of the toxicity of pharmaceuticals in humans and in animals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Mortality in the Survival With ORal D-sotalol (SWORD) trial: why did patients die?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Early after-depolarizations and torsade de pointes: implications for the control of cardiac arrhythmias by prolonging repolarization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

QT prolongation associated with azithromycin/amiodarone combination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

HERG K+ channels: friend and foe.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Chaos and the transition to ventricular fibrillation: a new approach to antiarrhythmic drug evaluation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Cellular basis for the electrocardiographic J wave

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Risk of torsades de pointes with non-cardiac drugs. Doctors need to be aware that many drugs can cause qt prolongation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

Detection of proarrhythmia in the female rabbit heart: blinded validation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2004.03.008

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.VASCN.2004.03.008

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10 August 2017

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