Mathematical and computational models of immune-receptor signalling (Q35790365)

10 August 2017

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title

Mathematical and computational models of immune-receptor signalling (English)

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10 August 2017

Byron Goldstein

1

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10 August 2017

James R Faeder

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2

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10 August 2017

William S Hlavacek

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3

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10 August 2017

language of work or name

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1 June 2004

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Nature Reviews Immunology

10 August 2017

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10 August 2017

4

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10 August 2017

6

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10 August 2017

445-456

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https://scigraph.springernature.com/pub.10.1038/nri1374

10 August 2017

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cites work

Multichain immune recognition receptors: similarities in structure and signaling pathways

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Antigen receptor tail clue.

21 January 2018

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21 January 2018

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The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers

21 January 2018

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The tandem Src homology 2 domain of the Syk kinase: a molecular device that adapts to interphosphotyrosine distances

21 January 2018

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T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

21 January 2018

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An unusual mechanism for ligand antagonism

21 January 2018

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TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

21 January 2018

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Signal transduction: hanging on a scaffold.

21 January 2018

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Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties

21 January 2018

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Investigation of early events in Fc epsilon RI-mediated signaling using a detailed mathematical model

21 January 2018

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Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades

21 January 2018

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Functional rafts in cell membranes

21 January 2018

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Synaptic pattern formation during cellular recognition

21 January 2018

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The immunological synapse balances T cell receptor signaling and degradation

21 January 2018

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Serial triggering of many T-cell receptors by a few peptide-MHC complexes

21 January 2018

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Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition

21 January 2018

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Retention of antigen on follicular dendritic cells and B lymphocytes through complement-mediated multivalent ligand-receptor interactions: theory and application to HIV treatment.

21 January 2018

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A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists

21 January 2018

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Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical

21 January 2018

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T-cell-receptor affinity and thymocyte positive selection

21 January 2018

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Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: implications for TCR signaling.

21 January 2018

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Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation

21 January 2018

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Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation

21 January 2018

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Kinetic discrimination in T-cell activation

21 January 2018

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A kinetic differentiation model for the action of altered TCR ligands.

21 January 2018

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Cooperative enhancement of specificity in a lattice of T cell receptors

21 January 2018

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Unexpected signals in a system subject to kinetic proofreading

21 January 2018

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Synthesis and secretion of monocyte chemotactic protein-1 stimulated by the high affinity receptor for IgE.

21 January 2018

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Kinetic proofreading models for cell signaling predict ways to escape kinetic proofreading

21 January 2018

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Kinetic proofreading in receptor-mediated transduction of cellular signals: receptor aggregation, partially activated receptors, and cytosolic messengers.

21 January 2018

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Kinetics and extent of protein tyrosine kinase activation in individual T cells upon antigenic stimulation

21 January 2018

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Serial triggering of T cell receptors results in incremental accumulation of signaling intermediates

21 January 2018

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A temporal and spatial summation model for T-cell activation: signal integration and antigen decoding

21 January 2018

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Direct observation of ligand recognition by T cells.

21 January 2018

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A reliable and safe T cell repertoire based on low-affinity T cell receptors.

21 January 2018

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Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

21 January 2018

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A mathematical analysis of TCR serial triggering and down-regulation.

21 January 2018

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Modeling the early signaling events mediated by FcepsilonRI.

21 January 2018

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The complexity of complexes in signal transduction.

21 January 2018

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Kinetics of tyrosine phosphorylation when IgE dimers bind to FC epsilon receptors on rat basophilic leukemia cells

21 January 2018

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Shuttling of initiating kinase between discrete aggregates of the high affinity receptor for IgE regulates the cellular response

21 January 2018

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One lyn molecule is sufficient to initiate phosphorylation of aggregated high-affinity IgE receptors

21 January 2018

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A lipid raft environment enhances Lyn kinase activity by protecting the active site tyrosine from dephosphorylation

21 January 2018

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Cutting Edge: Transmembrane phosphoprotein Csk-binding protein/phosphoprotein associated with glycosphingolipid-enriched microdomains as a negative feedback regulator of mast cell signaling through the FcepsilonRI

21 January 2018

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Mast cell signal transduction from the high-affinity IgE receptor

21 January 2018

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The synapse assembly model.

21 January 2018

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In silico models for cellular and molecular immunology: successes, promises and challenges.

21 January 2018

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A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts

21 January 2018

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Efficient Exact Stochastic Simulation of Chemical Systems with Many Species and Many Channels

21 January 2018

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Quantitative cell biology with the Virtual Cell

21 January 2018

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The unique domain as the site on Lyn kinase for its constitutive association with the high affinity receptor for IgE

21 January 2018

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Signalling through the high-affinity IgE receptor Fc epsilonRI.

21 January 2018

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Molecular mechanisms in B cell antigen receptor signaling

21 January 2018

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Signal transduction by the TCR for antigen

21 January 2018

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The nature of molecular recognition by T cells

21 January 2018

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Triggering the TCR Complex Causes the Downregulation of Nonengaged Receptors by a Signal Transduction-Dependent Mechanism

21 January 2018

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Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]

21 January 2018

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The magnitude of signal amplification by ligand-induced receptor clustering

31 March 2020

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Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain

31 March 2020

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Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance

31 March 2020

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Cross-antagonism of a T cell clone expressing two distinct T cell receptors

31 March 2020

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Differential segregation in a cell-cell contact interface: the dynamics of the immunological synapse

31 March 2020

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Activated TCRs remain marked for internalization after dissociation from pMHC

31 March 2020

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Calculations show substantial serial engagement of T cell receptors

31 March 2020

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Kinetic proofreading in T-cell receptor signal transduction

31 March 2020

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Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness

31 March 2020

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High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling

31 March 2020

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Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation

31 March 2020

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Peptide antagonism and T cell receptor interactions with peptide-MHC complexes

31 March 2020

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The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model

31 March 2020

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Cutting edge: T lymphocyte activation by repeated immunological synapse formation and intermittent signaling

31 March 2020

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Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response

31 March 2020

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From TCR Engagement to T Cell Activation

31 March 2020

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Stimulation of the high-affinity IgE receptor results in the tyrosine phosphorylation of a 60 kD protein which is associated with the protein-tyrosine kinase, Csk

31 March 2020

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Characterization of protein-tyrosine phosphatases that dephosphorylate the high affinity IgE receptor

31 March 2020

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Equilibrium thermodynamics of cell-cell adhesion mediated by multiple ligand-receptor pairs

31 March 2020

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Kinetic Proofreading: A New Mechanism for Reducing Errors in Biosynthetic Processes Requiring High Specificity

31 March 2020

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A general method for numerically simulating the stochastic time evolution of coupled chemical reactions

31 March 2020

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Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1374

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Dimensions Publication ID

10 August 2017

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