Catalytic contributions of key residues in the adenine glycosylase MutY revealed by pH-dependent kinetics and cellular repair assays (Q35799206)

10 August 2017

title

Catalytic contributions of key residues in the adenine glycosylase MutY revealed by pH-dependent kinetics and cellular repair assays (English)

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10 August 2017

Megan K Brinkmeyer

1

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10 August 2017

Mary Ann Pope

series ordinal

2

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10 August 2017

Sheila S David

series ordinal

3

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10 August 2017

publication date

1 February 2012

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10 August 2017

published in

Chemistry and Biology

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10 August 2017

volume

19

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10 August 2017

issue

2

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10 August 2017

page(s)

276-286

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Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine

10 August 2017

cites work

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Atomic substitution reveals the structural basis for substrate adenine recognition and removal by adenine DNA glycosylase

11 July 2018

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Adenine removal activity and bacterial complementation with the human MutY homologue (MUTYH) and Y165C, G382D, P391L and Q324R variants associated with colorectal cancer

11 July 2018

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DNA repair in mammalian cells: Base excision repair: the long and short of it.

11 July 2018

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Transition-state analysis of the DNA repair enzyme MutY.

11 July 2018

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Unnatural substrates reveal the importance of 8-oxoguanine for in vivo mismatch repair by MutY.

11 July 2018

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Base-excision repair of oxidative DNA damage

11 July 2018

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MUTYH-associated polyposis--from defect in base excision repair to clinical genetic testing

11 July 2018

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Physical and functional interactions between Escherichia coli MutY glycosylase and mismatch repair protein MutS

11 July 2018

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Toward a detailed understanding of base excision repair enzymes: transition state and mechanistic analyses of N-glycoside hydrolysis and N-glycoside transfer

11 July 2018

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Protein-DNA charge transport: redox activation of a DNA repair protein by guanine radical

11 July 2018

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Polymerases leave fingerprints: analysis of the mutational spectrum in Escherichia coli rpoB to assess the role of polymerase IV in spontaneous mutation

11 July 2018

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Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase

11 July 2018

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Human Alkyladenine DNA Glycosylase Uses Acid−Base Catalysis for Selective Excision of Damaged Purines

11 July 2018

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A mechanistic perspective on the chemistry of DNA repair glycosylases

11 July 2018

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Insight into the functional consequences of inherited variants of the hMYH adenine glycosylase associated with colorectal cancer: complementation assays with hMYH variants and pre-steady-state kinetics of the corresponding mutated E.coli enzymes

11 July 2018

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Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase

11 July 2018

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Genome maintenance mechanisms for preventing cancer

11 July 2018

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Efficient recognition of substrates and substrate analogs by the adenine glycosylase MutY requires the C-terminal domain

11 July 2018

1 reference

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Structural studies of human alkyladenine glycosylase and E. coli 3-methyladenine glycosylase

11 July 2018

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DNA bending and a flip-out mechanism for base excision by the helix–hairpin–helix DNA glycosylase, Escherichia coli AlkA

11 July 2018

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Role of electrophilic and general base catalysis in the mechanism of Escherichia coli uracil DNA glycosylase.

11 July 2018

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The active site of the Escherichia coli MutY DNA adenine glycosylase

11 July 2018

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Substrate recognition by Escherichia coli MutY using substrate analogs

11 July 2018

1 reference

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MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292766

Single-turnover and pre-steady-state kinetics of the reaction of the adenine glycosylase MutY with mismatch-containing DNA substrates

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292766

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

11 July 2018

1 reference

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The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)

11 July 2018

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A new method for sequencing DNA

11 July 2018

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Insight into the roles of tyrosine 82 and glycine 253 in the Escherichia coli adenine glycosylase MutY.

11 July 2018

1 reference

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A residue in MutY important for catalysis identified by photocross-linking and mass spectrometry

25 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292766

Probing the requirements for recognition and catalysis in Fpg and MutY with nonpolar adenine isosteres

25 September 2018

1 reference

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Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors

25 September 2018

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Site-directed mutagenesis of the cysteine ligands to the [4Fe-4S] cluster of Escherichia coli MutY

25 September 2018

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12 December 2020

Oxidative Nucleobase Modifications Leading to Strand Scission

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12 December 2020

Chemistry of Glycosylases and Endonucleases Involved in Base-Excision Repair

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12 December 2020

The C-terminal domain of the adenine-DNA glycosylase MutY confers specificity for 8-oxoguanine.adenine mispairs and may have evolved from MutT, an 8-oxo-dGTPase

1 reference

12 December 2020

10.1016/J.CHEMBIOL.2011.11.011

Identifiers

DOI

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10 August 2017

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10 August 2017

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