Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes (Q35799671)

10 August 2017

Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes (English)

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10 August 2017

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14 June 2020

Beatriz Merino

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14 June 2020

Ivan Quesada

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14 June 2020

Piero Marchetti

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14 June 2020

Miriam Cnop

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14 June 2020

author name string

Matilde Masini

2

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14 June 2020

Fabio A Grieco

4

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14 June 2020

Isabelle Millard

5

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14 June 2020

Christine Dubois

6

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14 June 2020

Decio L Eizirik

10

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14 June 2020

publication date

17 March 2015

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10 August 2017

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14 June 2020

volume

2

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14 June 2020

page(s)

378-385

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14 June 2020

issue

5

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Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study

14 June 2020

cites work

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Aberrant islet unfolded protein response in type 2 diabetes

11 July 2018

1 reference

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Pdx1 maintains β cell identity and function by repressing an α cell program

11 July 2018

1 reference

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RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate

11 July 2018

1 reference

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Expression of mesenchymal and α-cell phenotypic markers in islet β-cells in recently diagnosed diabetes.

11 July 2018

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Resveratrol prevents β-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet.

11 July 2018

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Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance

11 July 2018

1 reference

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X-box binding protein 1 is essential for insulin regulation of pancreatic α-cell function

11 July 2018

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Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure

11 July 2018

1 reference

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Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis

11 July 2018

1 reference

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The role of dysregulated glucagon secretion in type 2 diabetes

11 July 2018

1 reference

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Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion

11 July 2018

1 reference

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Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction

11 July 2018

1 reference

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Pancreatic alpha cell mass in European subjects with type 2 diabetes

11 July 2018

1 reference

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Pancreatic islet amyloidosis, beta-cell apoptosis, and alpha-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons

11 July 2018

1 reference

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Initiation and execution of lipotoxic ER stress in pancreatic beta-cells

11 July 2018

1 reference

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Glucolipotoxicity: fuel excess and beta-cell dysfunction.

11 July 2018

1 reference

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The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485913

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485913

Endoplasmic reticulum stress signaling in disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485913

Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis

11 July 2018

1 reference

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Applications of immunogold labeling in ultrastructural pathology

11 July 2018

1 reference

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Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485913

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485913

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485913

Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression

11 July 2018

1 reference

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The insulin factory: a tour of the plant surroundings and a visit to the assembly line. The Minkowski lecture 1973 revisited

11 July 2018

1 reference

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Postprandial lipemia induces pancreatic α cell dysfunction characteristic of type 2 diabetes: studies in healthy subjects, mouse pancreatic islets, and cultured pancreatic α cells.

11 July 2018

1 reference

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One-step purification of functional human and rat pancreatic alpha cells.

25 September 2018

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The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation.

25 September 2018

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Autophagy in human type 2 diabetes pancreatic beta cells.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485913

Pancreatic beta-cell mass in European subjects with type 2 diabetes

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4485913

Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

25 September 2018

1 reference

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A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM.

25 September 2018

1 reference

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Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels

25 September 2018

1 reference

12 December 2020

Involvement of oxidative stress-induced DNA damage, endoplasmic reticulum stress, and autophagy deficits in the decline of β-cell mass in Japanese type 2 diabetic patients

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12 December 2020

Use of RNA interference to investigate cytokine signal transduction in pancreatic beta cells

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12 December 2020

Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR

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12 December 2020

A new in vitro model for the study of pancreatic A and B cells

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12 December 2020

Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide

1 reference

12 December 2020

Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro

1 reference

12 December 2020

10.1016/J.EBIOM.2015.03.012

Identifiers

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14 June 2020

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14 June 2020

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