Gut wall metabolism of verapamil in older people: effects of rifampicin-mediated enzyme induction (Q35802166)

10 August 2017

Gut wall metabolism of verapamil in older people: effects of rifampicin-mediated enzyme induction (English)

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10 August 2017

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M F Fromm

1

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10 August 2017

K Dilger

2

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10 August 2017

D Busse

3

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10 August 2017

H K Kroemer

4

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10 August 2017

M Eichelbaum

5

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10 August 2017

U Klotz

6

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10 August 2017

language of work or name

English

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publication date

1 March 1998

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British Journal of Clinical Pharmacology

10 August 2017

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10 August 2017

45

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10 August 2017

3

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10 August 2017

247-255

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Expression of CYP3A4, CYP3A5 and CYP3A7 in human duodenal tissue

10 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

First-pass metabolism of midazolam by the human intestine.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

Age and gender related changes in stereoselective pharmacokinetics and pharmacodynamics of verapamil and norverapamil

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

Extrahepatic metabolism of drugs in humans

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

Verapamil stereoisomers during racemic verapamil administration: effects of aging and comparisons to administration of individual stereoisomers.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

CYP3A gene expression in human gut epithelium

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine*

11 July 2018

1 reference

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Pharmacokinetics, bioavailability and ECG response of verapamil in patients with liver cirrhosis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

Pharmacokinetics of (+)-, (-)- and (+/-)-verapamil after intravenous administration

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

Stereoselective first-pass metabolism of highly cleared drugs: studies of the bioavailability of L- and D-verapamil examined with a stable isotope technique

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

Verapamil pharmacodynamics and disposition in young and elderly hypertensive patients. Altered electrocardiographic and hypotensive responses

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man

11 July 2018

1 reference

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Erythromycin enhances the absorption of cyclosporin

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients

11 July 2018

1 reference

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The effect of age upon liver volume and apparent liver blood flow in healthy man.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

Hepatic drug metabolism and aging

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

Aging alters verapamil elimination and dynamics: single dose and steady-state responses.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

The influence of age on the pharmacokinetics of verapamil.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

Effect of age and gender on the activity of human hepatic CYP3A

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

Predictability of the in vivo metabolism of verapamil from in vitro data: contribution of individual metabolic pathways and stereoselective aspects

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

Gerontokinetics--a reappraisal

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

The effects of age and liver disease on the disposition and elimination of diazepam in adult man

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

The effect of ageing on the hepatic clearance of propranolol

11 July 2018

1 reference

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Effects of age and cigarette smoking on propranolol disposition

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

Aging effects on stereoselective pharmacokinetics and pharmacodynamics of verapamil.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

Aging of women alters S-verapamil pharmacokinetics and pharmacodynamics

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

Pharmacokinetics of oral and intravenous rifampicin during chronic administration

25 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1046%2FJ.1365-2125.1998.00669.X

Interaction of verapamil and cimetidine: stereochemical aspects of drug metabolism, drug disposition and drug action

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873368

Stereoselective protein binding of verapamil enantiomers

25 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1046%2FJ.1365-2125.1998.00669.X

Physiological disposition of verapamil in man

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1046%2FJ.1365-2125.1998.00669.X

Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans

21 January 2018

1 reference

12 December 2020

Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin

1 reference

12 December 2020

Influence of renal function on the steady-state pharmacokinetics of the antiarrhythmic propafenone and its Phase I and Phase II metabolites

1 reference

12 December 2020

The effect of dextro-, levo-, and racemic verapamil on atrioventricular conduction in humans

1 reference

12 December 2020

Effects of d,l-verapamil on atrioventricular conduction in relation to its stereoselective first-pass metabolism

1 reference

12 December 2020

Aging and drug interactions. II. Effect of phenytoin and smoking on the oxidation of theophylline and cortisol in healthy men

1 reference

12 December 2020

Near-total reduction in verapamil bioavailability by rifampin. Electrocardiographic correlates

1 reference

12 December 2020

Electrophysiologic effects of dextro- and levo-verapamil on sinus node and AV node function in humans

1 reference

12 December 2020

Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues

1 reference

12 December 2020

Effects of age and gender on in vitro properties of human liver microsomal monooxygenases

1 reference

12 December 2020

First-pass metabolism of cyclosporin by the gut

1 reference

12 December 2020

Induction of cytochrome P450IA genes (CYP1A) by omeprazole in the human alimentary tract

1 reference

12 December 2020

Simultaneous assessment of the intravenous and oral disposition of the enantiomers of racemic nimodipine by chiral stationary-phase high-performance liquid chromatography and gas chromatography/mass spectroscopy combined with a stable isotope techni

1 reference

12 December 2020

Stereoselective verapamil disposition and dynamics in aging during racemic verapamil administration

1 reference

12 December 2020

The effects of age and gender on the stereoselective pharmacokinetics of verapamil

1 reference

12 December 2020

Identification of P450 enzymes involved in metabolism of verapamil in humans

1 reference

12 December 2020

An enantiomer-enantiomer interaction of (S)- and (R)-propafenone modifies the effect of racemic drug therapy

1 reference

12 December 2020

Disposition of intravenous and oral cyclosporine after administration with grapefruit juice

1 reference

12 December 2020

Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver

1 reference

12 December 2020

Superiority of stable isotope techniques in the assessment of the bioavailability of drugs undergoing extensive first pass elimination. Studies of the relative bioavailability of verapamil tablets

1 reference

12 December 2020

10.1046/J.1365-2125.1998.00669.X

Identifiers

DOI

1 reference

10 August 2017

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10 August 2017

PubMed publication ID

9517368

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