MTTP-297H polymorphism reduced serum cholesterol but increased risk of non-alcoholic fatty liver disease-a cross-sectional study. (Q35803568)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26458397%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

title

MTTP-297H polymorphism reduced serum cholesterol but increased risk of non-alcoholic fatty liver disease-a cross-sectional study (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26458397%20AND%20SRC:MED&resulttype=core&format=json

non-alcoholic fatty liver

26 February 2020

main subject

1 reference

metabolic dysfunction–associated steatotic liver disease

inferred from title

1 reference

1

1 reference

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26 February 2020

He-Jiun Jiang

4

1 reference

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26 February 2020

Yi-Hsin Yang

6

1 reference

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26 February 2020

author name string

Mei-Yueh Lee

2

1 reference

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26 February 2020

Yeng-Tseng Wang

3

1 reference

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26 February 2020

Pi-Chen Lin

5

1 reference

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26 February 2020

Kung-Kai Kuo

7

1 reference

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26 February 2020

publication date

12 October 2015

1 reference

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26 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26458397%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

volume

16

1 reference

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26 February 2020

page(s)

93

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Novel missense MTTP gene mutations causing abetalipoproteinemia

26 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

Lomitapide: A novel agent for the treatment of homozygous familial hypercholesterolemia

11 July 2018

1 reference

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Hypobetalipoproteinemia and abetalipoproteinemia

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

Potential approaches to ameliorate hepatic fat accumulation seen with MTP inhibition

11 July 2018

1 reference

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Lomitapide and mipomersen: two first-in-class drugs for reducing low-density lipoprotein cholesterol in patients with homozygous familial hypercholesterolemia

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

MTP -493G>T polymorphism and susceptibility to nonalcoholic fatty liver disease: a meta-analysis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

Differential impact of hepatic deficiency and total body inhibition of MTP on cholesterol metabolism and RCT in mice.

11 July 2018

1 reference

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Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis

11 July 2018

1 reference

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New LDL-cholesterol lowering therapies: pharmacology, clinical trials, and relevance to acute coronary syndromes

11 July 2018

1 reference

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Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia

11 July 2018

1 reference

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Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease

11 July 2018

1 reference

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Lumenal lipid metabolism: implications for lipoprotein assembly

11 July 2018

1 reference

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Multiple functions of microsomal triglyceride transfer protein

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

Phospholipid transfer activity of microsomal triglyceride transfer protein produces apolipoprotein B and reduces hepatosteatosis while maintaining low plasma lipids in mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

A protocol for computer-based protein structure and function prediction

11 July 2018

1 reference

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SDM--a server for predicting effects of mutations on protein stability and malfunction

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

Allele-specific regulation of MTTP expression influences the risk of ischemic heart disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

Abetalipoproteinemia: two case reports and literature review

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

The N-terminal 1000 residues of apolipoprotein B associate with microsomal triglyceride transfer protein to create a lipid transfer pocket required for lipoprotein assembly

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

Visceral obesity and hyperinsulinemia modulate the impact of the microsomal triglyceride transfer protein -493G/T polymorphism on plasma lipoprotein levels in men.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

Mipomersen, an apolipoprotein B synthesis inhibitor, reduces atherogenic lipoproteins in patients with severe hypercholesterolemia at high cardiovascular risk: a randomized, double-blind, placebo-controlled trial

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

MTTP polymorphisms and susceptibility to non-alcoholic fatty liver disease in a Han Chinese population

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

Lipoprotein metabolism mediates the association of MTP polymorphism with beta-cell dysfunction in healthy subjects and in nondiabetic normolipidemic patients with nonalcoholic steatohepatitis

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

MTTP variants and body mass index, waist circumference and serum cholesterol level: Association analyses in 7582 participants of the KORA study cohort

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

The influence of polymorphism of -493G/T MTP gene promoter and metabolic syndrome on lipids, fatty acids and oxidative stress.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

Significant correlations between severe fatty liver and risk factors for metabolic syndrome

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

Microsomal triglyceride transfer protein -493T variant reduces IDL plus LDL apoB production and the plasma concentration of large LDL particles

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

Effect of the microsomal triglyceride transfer protein -493 G/T polymorphism and type 2 diabetes mellitus on LDL subfractions

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

Variants of the microsomal triglyceride transfer protein gene are associated with plasma cholesterol levels and body mass index

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

A common functional polymorphism in the promoter region of the microsomal triglyceride transfer protein gene influences plasma LDL levels

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603340

Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression

15 November 2018

1 reference

12 December 2020

N-terminal domain of apolipoprotein B has structural homology to lipovitellin and microsomal triglyceride transfer protein: a "lipid pocket" model for self-assembly of apob-containing lipoprotein particles

1 reference

12 December 2020

Effect of microsomal triglyceride transfer protein gene variants (-493G > T, Q95H and H297Q) on plasma lipid levels in healthy middle-aged UK men

1 reference

12 December 2020

Homozygous MTTP and APOB mutations may lead to hepatic steatosis and fibrosis despite metabolic differences in congenital hypocholesterolemia

1 reference

12 December 2020

Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the second step

1 reference

12 December 2020

The Ile128Thr polymorphism influences stability and ligand binding properties of the microsomal triglyceride transfer protein

1 reference

12 December 2020

10.1186/S12881-015-0242-6

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26458397%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

26 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26458397%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

PubMed publication ID

26458397

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26458397%20AND%20SRC:MED&resulttype=core&format=json