Factor VIII Is Synthesized in Human Endothelial Cells, Packaged in Weibel-Palade Bodies and Secreted Bound to ULVWF Strings (Q35810108)

10 August 2017

Factor VIII Is Synthesized in Human Endothelial Cells, Packaged in Weibel-Palade Bodies and Secreted Bound to ULVWF Strings (English)

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10 August 2017

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Nancy A Turner

1

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10 August 2017

Joel L Moake

series ordinal

2

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10 August 2017

language of work or name

English

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publication date

16 October 2015

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10 August 2017

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10 August 2017

10

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10 August 2017

10

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10 August 2017

e0140740

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Creative Commons Attribution 4.0 International

10 August 2017

start time

16 October 2015

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII.

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ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions

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11 July 2018

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Production processes of licensed recombinant factor VIII preparations

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Intracellular trafficking of factor VIII to von Willebrand factor storage granules

11 July 2018

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11 July 2018

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11 July 2018

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Molecular cloning of a cDNA encoding human antihaemophilic factor

11 July 2018

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Characterization of the polypeptide composition of human factor VIII:C and the nucleotide sequence and expression of the human kidney cDNA.

11 July 2018

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11 July 2018

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Identification of six functional clotting factor VIII:C epitopes by analysis of cross-reactive public idiotypes in murine monoclonal VIII:C inhibitors

11 July 2018

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Induction of specific storage organelles by von Willebrand factor propolypeptide

11 July 2018

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Human liver sinusoidal endothelial cells but not hepatocytes contain factor VIII.

11 July 2018

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Activation of human endothelial cells from specific vascular beds induces the release of a FVIII storage pool

25 September 2018

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The physiological function of von Willebrand's factor depends on its tubular storage in endothelial Weibel-Palade bodies

25 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4608722

Expression of factor VIII by murine liver sinusoidal endothelial cells

25 September 2018

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A molecular model for the triplicated A domains of human factor VIII based on the crystal structure of human ceruloplasmin.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4608722

Expression of active human factor VIII from recombinant DNA clones

25 September 2018

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Monoclonal antibodies to human procoagulant factor VIII.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4608722

Factor VIII alters tubular organization and functional properties of von Willebrand factor stored in Weibel-Palade bodies

25 September 2018

1 reference

12 December 2020

FVIII production by human lung microvascular endothelial cells

1 reference

12 December 2020

Role of the low density lipoprotein-related protein receptor in mediation of factor VIII catabolism

1 reference

12 December 2020

Intracellular cotrafficking of factor VIII and von Willebrand factor type 2N variants to storage organelles

1 reference

12 December 2020

The Light Chain of Factor VIII Comprises a Binding Site for Low Density Lipoprotein Receptor-related Protein

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0140740

Identifiers

DOI

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10 August 2017

0 references

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10 August 2017

PubMed publication ID

26473492

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