Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload. (Q35815013)

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6 November 2019

title

Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload (English)

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6 November 2019

9

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8

Dorothy E Vatner

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6 November 2019

10

Stephen F Vatner

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6 November 2019

author name string

Satoshi Okumura

1

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6 November 2019

Gen Takagi

2

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6 November 2019

Jun-ichi Kawabe

3

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6 November 2019

Guiping Yang

4

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6 November 2019

Ming-Chih Lee

5

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6 November 2019

Chull Hong

6

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6 November 2019

Jing Liu

7

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6 November 2019

Yoshihiro Ishikawa

11

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6 November 2019

language of work or name

English

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publication date

6 August 2003

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Proceedings of the National Academy of Sciences of the United States of America

6 November 2019

published in

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6 November 2019

volume

100

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issue

17

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6 November 2019

page(s)

9986-9990

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Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes

6 November 2019

cites work

1 reference

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Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase

11 July 2018

1 reference

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Enhanced cardiac function in transgenic mice expressing a Ca(2+)-stimulated adenylyl cyclase

11 July 2018

1 reference

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Beta-adrenergic receptor-G protein-adenylyl cyclase signal transduction in the failing heart

11 July 2018

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beta-adrenergic receptor signaling: an acute compensatory adjustment-inappropriate for the chronic stress of heart failure? Insights from Gsalpha overexpression and other genetically engineered animal models

11 July 2018

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Altering the receptor-effector ratio by transgenic overexpression of type V adenylyl cyclase: enhanced basal catalytic activity and function without increased cardiomyocyte beta-adrenergic signalling

11 July 2018

1 reference

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Beta-adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic G(salpha) mouse

11 July 2018

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Transgenic replacement of type V adenylyl cyclase identifies a critical mechanism of beta-adrenergic receptor dysfunction in the G alpha q overexpressing mouse

11 July 2018

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Apoptosis in heart failure: release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy

11 July 2018

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Cardiac-directed adenylyl cyclase expression improves heart function in murine cardiomyopathy

11 July 2018

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Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice.

11 July 2018

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Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase

11 July 2018

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The adenylyl cyclases as integrators of transmembrane signal transduction

11 July 2018

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Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. MOCHA Investigators.

11 July 2018

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Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis

11 July 2018

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The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group

11 July 2018

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Type V, but not type VI, adenylyl cyclase mRNA accumulates in the rat heart during ontogenic development. Correlation with increased global adenylyl cyclase activity

11 July 2018

1 reference

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Downregulation of adenylylcyclase types V and VI mRNA levels in pacing-induced heart failure in dogs

11 July 2018

1 reference

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Augmentation of cardiac contractility with no change in L-type Ca2+ current in transgenic mice with a cardiac-directed expression of the human adenylyl cyclase type 8 (AC8).

11 July 2018

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Adenylyl cyclase increases survival in cardiomyopathy

24 September 2018

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Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase a.

24 September 2018

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A low-molecular-weight fraction of human seminal plasma activates adenylyl cyclase and induces caspase 3-independent apoptosis in prostatic epithelial cells by decreasing mitochondrial potential and Bcl-2/Bax ratio

24 September 2018

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Changes in type VI adenylyl cyclase isoform expression correlate with a decreased capacity for cAMP generation in the aging ventricle.

24 September 2018

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Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level

24 September 2018

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12 December 2020

Myocardial-directed overexpression of the human beta(1)-adrenergic receptor in transgenic mice

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12 December 2020

p38 mitogen-activated protein kinase pathway protects adult rat ventricular myocytes against beta -adrenergic receptor-stimulated apoptosis. Evidence for Gi-dependent activation

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12 December 2020

Is treating cardiac hypertrophy salutary or detrimental: the two faces of Janus

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12 December 2020

Role of blood pressure in the development of congestive heart failure. The Framingham study

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12 December 2020

Adverse effects of chronic endogenous sympathetic drive induced by cardiac GS alpha overexpression

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12 December 2020

Cardiomyopathy induced by cardiac Gs alpha overexpression

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12 December 2020

Adenylylcyclase increases responsiveness to catecholamine stimulation in transgenic mice

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12 December 2020

Cyclosporine attenuates pressure-overload hypertrophy in mice while enhancing susceptibility to decompensation and heart failure

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12 December 2020

beta(2)-adrenergic receptor overexpression exacerbates development of heart failure after aortic stenosis

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1733772100

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6 November 2019

0 references

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6 November 2019

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