Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine (Q35819812)

10 August 2017

Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine (English)

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10 August 2017

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L A Turka

1

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10 August 2017

J Dayton

2

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10 August 2017

G Sinclair

3

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10 August 2017

C B Thompson

4

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10 August 2017

B S Mitchell

5

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10 August 2017

language of work or name

English

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publication date

1 March 1991

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Journal of Clinical Investigation

10 August 2017

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10 August 2017

87

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10 August 2017

3

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10 August 2017

940-948

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The effects of azathioprine (imuran) on purine synthesis in clinical disorders of purine metabolism

10 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

2'-deoxyguanosine toxicity for B and mature T lymphoid cell lines is mediated by guanine ribonucleotide accumulation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Biochemistry of Diseases of Immunodevelopment

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Human T-cell growth factor: partial amino acid sequence, cDNA cloning, and organization and expression in normal and leukemic cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Isolation and partial nucleotide sequence of a cDNA clone for human histocompatibility antigen HLA-B by use of an oligodeoxynucleotide primer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Genetic and biochemical studies on the activation and cytotoxic mechanism of bredinin, a potent inhibitor of purine biosynthesis in mammalian cells.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Studies on bredinin. I. Isolation, characterization and biological properties

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Phase I evaluation and pharmacokinetics of tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide, NSC 286193).

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Novel promoter upstream of the human c-myc gene and regulation of c-myc expression in B-cell lymphomas

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Mycophenolic acid for psoriasis. A review of pharmacology, long-term efficacy, and safety

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Effects of combination cyclosporine/mizoribine immunosuppression on canine renal allograft recipients.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Effects of mizoribine on canine renal allograft recipients

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Crosslinking of surface antigens causes mobilization of intracellular ionized calcium in T lymphocytes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Multiple mechanisms regulate c-myc gene expression during normal T cell activation.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Antibody binding to CD5 (Tp67) and Tp44 T cell surface molecules: effects on cyclic nucleotides, cytoplasmic free calcium, and cAMP-mediated suppression

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Aluminum fluoride induces phosphatidylinositol turnover, elevation of cytoplasmic free calcium, and phosphorylation of the T cell antigen receptor in murine T cells.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

G1 events and regulation of cell proliferation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Regulation of T lymphocyte proliferation. Interleukin 2-mediated induction of c-myb gene expression is dependent on T lymphocyte activation state

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Evidence for the involvement of three distinct signals in the induction of IL-2 gene expression in human T lymphocytes.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Mode of action of bredinin with guanylic acid on L5178Y mouse leukemia cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Deoxyguanosine Triphosphate as a Possible Toxic Metabolite in the Immunodeficiency Associated with Purine Nucleoside Phosphorylase Deficiency

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Inhibition of purine nucleoside phosphorylase by 8-aminoguanosine: selective toxicity for T lymphoblasts

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Induction of Interleukin 2 Messenger RNA Inhibited by Cyclosporin A

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Identification and functional characterization of two distinct epitopes on the human T cell surface protein Tp50

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Stimulation of p21 ras upon T-cell activation

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=329885

Synergistically enhanced immunosuppressive effect by combined use of cyclosporine and mizoribine

15 November 2018

1 reference

12 December 2020

Expression of the c-myb proto-oncogene during cellular proliferation

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12 December 2020

Anti-CD3 antibody induces unresponsiveness to IL-2 in Th1 clones but not in Th2 clones

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12 December 2020

Immunosuppressive effect of bredinin in the management of patients with renal transplantation

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12 December 2020

GTP depletion and other erythrocyte abnormalities in inherited PNP deficiency

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12 December 2020

The immunosuppressive mode of action of mizoribine

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12 December 2020

Immunosuppressive mode of action of deoxyspergualin in mice, as compared with cyclosporine A and mizoribine

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12 December 2020

The synergistic effect of cyclosporine and mizoribine on heterotopic heart and partial-lung transplantation in rats

1 reference

12 December 2020

Combined immunosuppression with low-dose cyclosporine, mizoribine, and prednisolone

1 reference

12 December 2020

Guanine nucleotide depletion and toxicity in mouse T lymphoma (S-49) cells

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12 December 2020

Bredinin treatment in clinical kidney allografting

1 reference

12 December 2020

Covalent association between human thymus leukemia-like antigens and CD8(Tp32) molecules

1 reference

12 December 2020

Formation of the 3′ end of histone mRNA by post-transcriptional processing

1 reference

12 December 2020

Studies on immunosuppression with low-dose cyclosporine combined with mizoribine in experimental and clinical cadaveric renal allotransplantation

1 reference

12 December 2020

A clinical study of renal transplant patients receiving triple-drug therapy--cyclosporine A, mizoribine, and prednisolone

1 reference

12 December 2020

Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production

1 reference

12 December 2020

Synergistic effect of cyclosporine and mizoribine on survival of dog renal allografts

1 reference

12 December 2020

Immunosuppression with low-dose cyclosporine combined with bredinin and prednisolone

1 reference

12 December 2020

Antibodies to Tp67 and Tp44 augment and sustain proliferative responses of activated T cells

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI115101

1 reference

10 August 2017

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10 August 2017

PubMed publication ID

1999502

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