Drug development in oncology: classical cytotoxics and molecularly targeted agents (Q35827606)

10 August 2017

1 reference

title

Drug development in oncology: classical cytotoxics and molecularly targeted agents (English)

1 reference

10 August 2017

Shivaani Kummar

1

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10 August 2017

Martin Gutierrez

series ordinal

2

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10 August 2017

James H Doroshow

series ordinal

3

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10 August 2017

Anthony J Murgo

series ordinal

4

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10 August 2017

language of work or name

English

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publication date

1 July 2006

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British Journal of Clinical Pharmacology

10 August 2017

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10 August 2017

62

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10 August 2017

1

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10 August 2017

15-26

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Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme

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The progress and promise of molecular imaging probes in oncologic drug development

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1 reference

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Implications of pharmacogenomics for drug development and clinical practice

27 July 2018

1 reference

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Modulation of cytochrome P450 activity: implications for cancer therapy

27 July 2018

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Design issues of randomized phase II trials and a proposal for phase II screening trials

27 July 2018

1 reference

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Expanding the use of magnetic resonance in the assessment of tumor response to therapy: workshop report

27 July 2018

1 reference

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Adverse interaction between capecitabine and warfarin resulting in altered coagulation parameters and bleeding: case report and review of the literature

27 July 2018

1 reference

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Drug-drug interactions in oncology: why are they important and can they be minimized?

27 July 2018

1 reference

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Nanosuspensions in drug delivery

27 July 2018

1 reference

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Drug interactions in oncology

27 July 2018

1 reference

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27 July 2018

1 reference

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

27 July 2018

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Phase 1 trial of irinotecan (CPT-11) in patients with recurrent malignant glioma: a North American Brain Tumor Consortium study

27 July 2018

1 reference

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Cancer pharmacogenetics: polymorphisms, pathways and beyond

27 July 2018

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Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor

27 July 2018

1 reference

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Pharmacogenomics: road to anticancer therapeutics nirvana?

27 July 2018

1 reference

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Targeting epidermal growth factor receptor--are we missing the mark?

27 July 2018

1 reference

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Improving the evaluation of new cancer treatments: challenges and opportunities

27 July 2018

1 reference

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End points and United States Food and Drug Administration approval of oncology drugs

27 July 2018

1 reference

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Effects of St. John's wort on irinotecan metabolism

27 July 2018

1 reference

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Development of target-based antineoplastic agents

27 July 2018

1 reference

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New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

27 July 2018

1 reference

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Improved designs for dose escalation studies using pharmacokinetic measurements.

27 July 2018

1 reference

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Design and analysis of phase I clinical trials

27 July 2018

1 reference

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Designs for efficient clinical trials

27 July 2018

1 reference

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Continual reassessment method: a practical design for phase 1 clinical trials in cancer.

27 July 2018

1 reference

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Pharmacologically guided phase I clinical trials based upon preclinical drug development

27 July 2018

1 reference

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Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08.

27 July 2018

1 reference

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Pharmacogenetics of irinotecan: a promoter polymorphism of UGT1A1 gene and severe adverse reactions to irinotecan

24 September 2018

1 reference

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Determination of HER2 gene amplification by fluorescence in situ hybridization and concordance with the clinical trials immunohistochemical assay in women with metastatic breast cancer evaluated for treatment with trastuzumab

24 September 2018

1 reference

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Biomarkers for assessment of pharmacologic activity for a vascular endothelial growth factor (VEGF) receptor inhibitor, PTK787/ZK 222584 (PTK/ZK): translation of biological activity in a mouse melanoma metastasis model to phase I studies in patients

24 September 2018

1 reference

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Phase I trial of tipifarnib in patients with recurrent malignant glioma taking enzyme-inducing antiepileptic drugs: a North American Brain Tumor Consortium Study.

24 September 2018

1 reference

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Dynamic contrast-enhanced magnetic resonance imaging as a pharmacodynamic measure of response after acute dosing of AG-013736, an oral angiogenesis inhibitor, in patients with advanced solid tumors: results from a phase I study.

24 September 2018

1 reference

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Imaging and other biomarkers in early clinical studies: one step at a time or re-engineering drug development?

24 September 2018

1 reference

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Targeting EGFR in non-small-cell lung cancer

24 September 2018

1 reference

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Personalized drug therapy; the genome, the chip and the physician

24 September 2018

1 reference

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Sequence effect of docetaxel and carboplatin on toxicity, tumor response and pharmacokinetics in non-small-cell lung cancer patients: a phase I study of two sequences

24 September 2018

1 reference

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Measuring Response in Solid Tumors: Comparison of RECIST and WHO Response Criteria

24 September 2018

1 reference

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Pharmacology of oxaliplatin in solid tumor patients with hepatic dysfunction: a preliminary report of the national cancer institute organ dysfunction working group

24 September 2018

1 reference

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Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PTK787/ZK 222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases, in patients with advanced colorectal cancer a

24 September 2018

1 reference

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Dose-escalating and pharmacological study of oxaliplatin in adult cancer patients with impaired renal function: a National Cancer Institute Organ Dysfunction Working Group Study

24 September 2018

1 reference

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Rethinking clinical trials for cytostatic drugs

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885070

Functional imaging in phase I studies: decorations or decision making?

24 September 2018

1 reference

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Clinical trial design for target-based therapy

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885070

BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885070

Influence of unrecognized molecular heterogeneity on randomized clinical trials

24 September 2018

1 reference

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Anticancer agents targeting signaling molecules and cancer cell environment: challenges for drug development?

24 September 2018

1 reference

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O6-benzylguanine: a clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair.

24 September 2018

1 reference

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There are no bad anticancer agents, only bad clinical trial designs--twenty-first Richard and Hinda Rosenthal Foundation Award Lecture.

24 September 2018

1 reference

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Regulatory considerations for preclinical development of anticancer drugs

24 September 2018

1 reference

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Dihydroartemisinin downregulates vascular endothelial growth factor expression and induces apoptosis in chronic myeloid leukemia K562 cells

24 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2006.02713.X

Differences in N-acetylation of the experimental antitumor agent batracylin in the mouse and the rat

21 January 2018

1 reference

12 December 2020

Accelerated titration designs for phase I clinical trials in oncology

1 reference

12 December 2020

End points in cancer clinical trials and the drug approval process

1 reference

12 December 2020

Randomized discontinuation design: application to cytostatic antineoplastic agents

1 reference

12 December 2020

Potential roles for preclinical pharmacology in phase I clinical trials

1 reference

12 December 2020

Dose escalation trial designs based on a molecularly targeted endpoint

1 reference

12 December 2020

Evaluation of randomized discontinuation design

1 reference

12 December 2020

10.1111/J.1365-2125.2006.02713.X

Identifiers

DOI

1 reference

10 August 2017

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10 August 2017

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