Co-inhibition of polo-like kinase 1 and Aurora kinases promotes mitotic catastrophe. (Q35832355)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25871386%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

Co-inhibition of polo-like kinase 1 and Aurora kinases promotes mitotic catastrophe (English)

1 reference

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5 March 2020

5

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5 March 2020

Hoi Tang Ma

6

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5 March 2020

author name string

Jingjing Li

1

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5 March 2020

Myung Jin Hong

2

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5 March 2020

Jeremy P H Chow

3

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5 March 2020

Wing Yu Man

4

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5 March 2020

Randy Y C Poon

7

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5 March 2020

language of work or name

English

0 references

publication date

1 April 2015

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5 March 2020

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5 March 2020

volume

6

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5 March 2020

issue

11

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5 March 2020

page(s)

9327-9340

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Synergism between inhibitors of Aurora A and KIF11 overcomes KIF15-dependent drug resistance

5 March 2020

cites work

1 reference

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DNA damage checkpoints in nasopharyngeal carcinoma.

11 July 2018

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Dovitinib induces mitotic defects and activates the G2 DNA damage checkpoint

11 July 2018

1 reference

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p53 deficiency enhances mitotic arrest and slippage induced by pharmacological inhibition of Aurora kinases

11 July 2018

1 reference

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Current clinical trials with polo-like kinase 1 inhibitors in solid tumors

11 July 2018

1 reference

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Furry protein promotes aurora A-mediated Polo-like kinase 1 activation.

11 July 2018

1 reference

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The chromosomal passenger complex activates Polo kinase at centromeres

11 July 2018

1 reference

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Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

11 July 2018

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Update on Aurora Kinase Targeted Therapeutics in Oncology

11 July 2018

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How protein kinases co-ordinate mitosis in animal cells.

11 July 2018

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Aurora B kinase activation requires survivin priming phosphorylation by PLK1.

11 July 2018

1 reference

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Shared and separate functions of polo-like kinases and aurora kinases in cancer

11 July 2018

1 reference

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The Plk1-dependent phosphoproteome of the early mitotic spindle

11 July 2018

1 reference

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Biology of Aurora A kinase: implications in cancer manifestation and therapy

11 July 2018

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BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity

11 July 2018

1 reference

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Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression

11 July 2018

1 reference

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Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496220

Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496220

Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496220

Aurora kinases as anticancer drug targets

11 July 2018

1 reference

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Chromosomal passengers: conducting cell division

11 July 2018

1 reference

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BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.

11 July 2018

1 reference

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In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1.

11 July 2018

1 reference

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Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496220

Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways

11 July 2018

1 reference

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A roller coaster ride with the mitotic cyclins

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496220

Aurora-kinase inhibitors as anticancer agents

11 July 2018

1 reference

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Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496220

DNA Damage during the Spindle-Assembly Checkpoint Degrades CDC25A, Inhibits Cyclin–CDC2 Complexes, and Reverses Cells to Interphase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496220

Plk1 promotes nuclear translocation of human Cdc25C during prophase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496220

Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496220

Nasopharyngeal carcinoma cell line (C666-1) consistently harbouring Epstein-Barr virus

11 July 2018

1 reference

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Differential responses of proliferating versus quiescent cells to adriamycin

11 July 2018

1 reference

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Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation

11 July 2018

1 reference

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Cytogenetic studies on an epithelial cell line derived from poorly differentiated nasopharyngeal carcinoma

11 July 2018

1 reference

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Two epithelial tumor cell lines (HNE-1 and HONE-1) latently infected with Epstein-Barr virus that were derived from nasopharyngeal carcinomas

11 July 2018

1 reference

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Determination of subcutaneous tumor size in athymic (nude) mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496220

Pharmacological targeting the ATR-CHK1-WEE1 axis involves balancing cell growth stimulation and apoptosis.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496220

Orderly inactivation of the key checkpoint protein mitotic arrest deficient 2 (MAD2) during mitotic progression

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496220

Phosphorylation of TPX2 by Plx1 enhances activation of Aurora A.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496220

CDK1 inhibitors antagonize the immediate apoptosis triggered by spindle disruption but promote apoptosis following the subsequent rereplication and abnormal mitosis

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496220

Different Plk1 functions show distinct dependencies on Polo-Box domain-mediated targeting

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496220

Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496220

Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496220

The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1

24 September 2018

1 reference

12 December 2020

The polo-like kinase 1 regulates CDC25B-dependent mitosis entry

1 reference

12 December 2020

The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase

1 reference

12 December 2020

Degradation of Cyclin A Does Not Require Its Phosphorylation by CDC2 and Cyclin-dependent Kinase 2

1 reference

12 December 2020

Identifiers

DOI

10.18632/ONCOTARGET.3313

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25871386%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

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5 March 2020

PubMed publication ID

25871386

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25871386%20AND%20SRC:MED&resulttype=core&format=json