Polymorphic Variants of SCN1A and EPHX1 Influence Plasma Carbamazepine Concentration, Metabolism and Pharmacoresistance in a Population of Kosovar Albanian Epileptic Patients (Q35837256)

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scientific article published on 10 November 2015

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English	Polymorphic Variants of SCN1A and EPHX1 Influence Plasma Carbamazepine Concentration, Metabolism and Pharmacoresistance in a Population of Kosovar Albanian Epileptic Patients	scientific article published on 10 November 2015

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29 February 2020

Polymorphic Variants of SCN1A and EPHX1 Influence Plasma Carbamazepine Concentration, Metabolism and Pharmacoresistance in a Population of Kosovar Albanian Epileptic Patients (English)

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29 February 2020

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29 February 2020

Driton Vllasaliu

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29 February 2020

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Giangiacomo Beretta

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29 February 2020

Aida Shala

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29 February 2020

Valbona Govori

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29 February 2020

Giuseppe Danilo Norata

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29 February 2020

Shaip Krasniqi

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29 February 2020

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29 February 2020

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29 February 2020

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10 November 2015

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0 references

Association between PK/PD-involved gene polymorphisms and carbamazepine-individualized therapy.

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Effects of EPHX1 and CYP3A4 polymorphisms on carbamazepine metabolism in epileptic patients.

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Genetic association analysis of ATP binding cassette protein family reveals a novel association of ABCB1 genetic variants with epilepsy risk, but not with drug-resistance

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Significance of MDR1 gene polymorphism C3435T in predicting drug response in epilepsy

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The drug-transporter gene MDR1 C3435T and G2677T/A polymorphisms and the risk of multidrug-resistant epilepsy in Turkish children

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Effect of CYP3A5 genotypes on the pharmacokinetics of carbamazepine when used as monotherapy or co-administered with phenytoin, phenobarbital or valproic acid in Thai patients.

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Linkage disequilibrium between polymorphisms of ABCB1 and ABCC2 to predict the treatment outcome of Malaysians with complex partial seizures on treatment with carbamazepine mono-therapy at the Kuala Lumpur Hospital

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Steady-state carbamazepine pharmacokinetics following oral and stable-labeled intravenous administration in epilepsy patients: effects of race and sex

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ABCB1 C3435T polymorphism and the risk of resistance to antiepileptic drugs in epilepsy: a systematic review and meta-analysis

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Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009

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Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population

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Association between SCN1A polymorphism and carbamazepine-resistant epilepsy

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The relationship between the pharmacology of antiepileptic drugs and human gene variation: an overview

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Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)

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11 July 2018

Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin

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A novel mechanism underlying drug resistance in chronic epilepsy

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Non-synonymous single nucleotide alterations in the microsomal epoxide hydrolase gene and their functional effects

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Overview of the voltage-gated sodium channel family

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Is refractory epilepsy preventable?

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Partial and generalized epilepsy with febrile seizures plus and a novel SCN1A mutation

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Effectiveness of first antiepileptic drug.

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11 July 2018

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

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11 July 2018

Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema

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Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants

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Clinical pharmacokinetics and pharmacological effects of carbamazepine and carbamazepine-10,11-epoxide. An update

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Effects of major transporter and metabolizing enzyme gene polymorphisms on carbamazepine metabolism in Chinese patients with epilepsy

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24 September 2018

Effects of EPHX1, SCN1A and CYP3A4 genetic polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsy

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24 September 2018

SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.

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24 September 2018

SCN1AIVS5-91G>A polymorphism is associated with susceptibility to epilepsy but not with drug responsiveness

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24 September 2018

Association of polymorphisms in EPHX1, UGT2B7, ABCB1, ABCC2, SCN1A and SCN2A genes with carbamazepine therapy optimization.

1 reference

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A functional polymorphism in the SCN1A gene does not influence antiepileptic drug responsiveness in Italian patients with focal epilepsy

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Effects of ABCB1 polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsy.

1 reference

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24 September 2018

SCN1A splice variants exhibit divergent sensitivity to commonly used antiepileptic drugs

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24 September 2018

Effect of CYP3A5*3 genotype on serum carbamazepine concentrations at steady-state in Korean epileptic patients

1 reference

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24 September 2018

Genetic variants in microsomal epoxide hydrolase influence carbamazepine dosing.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640545

24 September 2018

A functional polymorphism in the SCN1A gene is not associated with carbamazepine dosages in Austrian patients with epilepsy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640545

24 September 2018

Association of MDR1 (C3435T) polymorphism and resistance to carbamazepine in epileptic patients from Turkey

1 reference

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24 September 2018

Systematic screening for polymorphisms in the CYP3A4 gene in the Chinese population.

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24 September 2018

Carbamazepine-resistance in the epileptic dentate gyrus of human hippocampal slices.

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24 September 2018

ABCB1 polymorphisms influence the response to antiepileptic drugs in Japanese epilepsy patients

1 reference

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24 September 2018

In vitro responsiveness of human-drug-resistant tissue to antiepileptic drugs: insights into the mechanisms of pharmacoresistance

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24 September 2018

Haplotype structures of EPHX1 and their effects on the metabolism of carbamazepine-10,11-epoxide in Japanese epileptic patients.

1 reference

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24 September 2018

A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer

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24 September 2018

Identification and functional characterization of eight CYP3A4 protein variants

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24 September 2018

Interindividual and interspecies variation in hepatic microsomal epoxide hydrolase activity: studies with cis-stilbene oxide, carbamazepine 10, 11-epoxide and naphthalene

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24 September 2018

Effect of CYP2C19 polymorphisms on the clinical outcome of low-dose clobazam therapy in Japanese patients with epilepsy

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21 January 2018

A commonSCN1Asplice-site polymorphism modifies the effect of carbamazepine on cortical excitability-A pharmacogenetic transcranial magnetic stimulation study

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21 January 2018

Association of Multidrug Resistance in Epilepsy with a Polymorphism in the Drug-Transporter GeneABCB1

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21 January 2018

Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation

1 reference

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12 December 2020

based on heuristic

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Effect of CYP3A5*3 on carbamazepine pharmacokinetics in Japanese patients with epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26555147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carbamazepine-10,11-diol steady-state serum levels and renal excretion during carbamazepine therapy in adults and children

1 reference

https://pubmed.ncbi.nlm.nih.gov/26555147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26555147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiepileptic drugs--best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/26555147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human hepatic microsomal epoxide hydrolase: comparative analysis of polymorphic expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/26555147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of association between ABCB1, ABCG2, and ABCC2 genetic polymorphisms and multidrug resistance in partial epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26555147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26555147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carbamazepine and lamotrigine plasma concentrations in epileptic patients during optimising therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26555147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0142408

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Europe PubMed Central

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29 February 2020

2015PLoSO..1042408D

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24 November 2022

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29 February 2020

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29 February 2020

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