PK11195, a peripheral benzodiazepine receptor (pBR) ligand, broadly blocks drug efflux to chemosensitize leukemia and myeloma cells by a pBR-independent, direct transporter-modulating mechanism (Q35847659)

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scientific article published on 28 July 2005

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English	PK11195, a peripheral benzodiazepine receptor (pBR) ligand, broadly blocks drug efflux to chemosensitize leukemia and myeloma cells by a pBR-independent, direct transporter-modulating mechanism	scientific article published on 28 July 2005

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scholarly article

1 reference

Europe PubMed Central

10 August 2017

PK11195, a peripheral benzodiazepine receptor (pBR) ligand, broadly blocks drug efflux to chemosensitize leukemia and myeloma cells by a pBR-independent, direct transporter-modulating mechanism (English)

1 reference

Europe PubMed Central

10 August 2017

Frederick R. Appelbaum

5

object named as

Frederick R Appelbaum

1 reference

Europe PubMed Central

10 August 2017

author name string

Roland B Walter

1

1 reference

Europe PubMed Central

10 August 2017

Jason L Pirga

2

1 reference

Europe PubMed Central

10 August 2017

Michelle R Cronk

3

1 reference

Europe PubMed Central

10 August 2017

Sasha Mayer

4

1 reference

Europe PubMed Central

10 August 2017

Deborah E Banker

6

1 reference

Europe PubMed Central

10 August 2017

language of work or name

0 references

publication date

28 July 2005

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

106

1 reference

Europe PubMed Central

10 August 2017

10

1 reference

Europe PubMed Central

10 August 2017

3584-3593

1 reference

Europe PubMed Central

10 August 2017

Cyclosporin A is a broad-spectrum multidrug resistance modulator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895053

11 July 2018

A Phase I trial of a potent P-glycoprotein inhibitor, zosuquidar trihydrochloride (LY335979), administered intravenously in combination with doxorubicin in patients with advanced malignancy

1 reference

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VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein

1 reference

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11 July 2018

Pumping of Drugs by P-Glycoprotein: A Two-Step Process?

1 reference

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11 July 2018

Analysis of P-glycoprotein-mediated membrane transport in human peripheral blood lymphocytes using the UIC2 shift assay.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895053

11 July 2018

Allosteric modulation of human P-glycoprotein. Inhibition of transport by preventing substrate translocation and dissociation

1 reference

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Side population cells and Bcrp1 expression in lung.

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Multidrug resistance in cancer: role of ATP-dependent transporters

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MDR1 bicistronic vectors: analysis of selection stringency, amplified gene expression, and vector stability in cell lines

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Drug resistance mechanisms in acute leukemia

1 reference

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11 July 2018

Novel mechanisms of drug resistance in leukemia

1 reference

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Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter

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Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

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Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site.

1 reference

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11 July 2018

Peripheral-type benzodiazepine receptor (PBR) in human breast cancer: correlation of breast cancer cell aggressive phenotype with PBR expression, nuclear localization, and PBR-mediated cell proliferation and nuclear transport of cholesterol

1 reference

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11 July 2018

Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities

1 reference

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11 July 2018

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

1 reference

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Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

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11 July 2018

Sensitive immunofluorescence detection of the expression of P-glycoprotein in malignant cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895053

11 July 2018

Interaction of combinations of drugs, chemosensitizers, and peptides with the P-glycoprotein multidrug transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895053

11 July 2018

Effects of amiodarone, cyclosporin A, and PSC 833 on the cytotoxicity of mitoxantrone, doxorubicin, and vincristine in non-P-glycoprotein human small cell lung cancer cell lines

1 reference

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11 July 2018

Staining with Hoechst 33342 and rhodamine 123: an attempt to detect multidrug resistant phenotype cells in leukemia

1 reference

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11 July 2018

The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance

1 reference

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Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

1 reference

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11 July 2018

The biochemistry of P-glycoprotein-mediated multidrug resistance

1 reference

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11 July 2018

Pharmacokinetics and effects on exercise heart rate of PK 11195 (52028 RP), an antagonist of peripheral benzodiazepine receptors, in healthy volunteers

1 reference

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Breast cancer resistance protein (BCRP/ABCG2) does not confer resistance to gemtuzumab ozogamicin and calicheamicin-gamma1 in acute myeloid leukemia cells.

1 reference

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Clinical effects and P-glycoprotein inhibition in patients with acute myeloid leukemia treated with zosuquidar trihydrochloride, daunorubicin and cytarabine

1 reference

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Targeting mitochondria to overcome conventional and bortezomib/proteasome inhibitor PS-341 resistance in multiple myeloma (MM) cells

1 reference

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Immunohistochemical assessment of the peripheral benzodiazepine receptor in breast cancer and its relationship with survival

1 reference

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Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies

1 reference

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24 September 2018

The peripheral benzodiazepine receptor ligand PK11195 overcomes different resistance mechanisms to sensitize AML cells to gemtuzumab ozogamicin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895053

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Multidrug resistance protein attenuates gemtuzumab ozogamicin-induced cytotoxicity in acute myeloid leukemia cells.

1 reference

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Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.

1 reference

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Single-cell image analysis to assess ABC-transporter-mediated efflux in highly purified hematopoietic progenitors

1 reference

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Cyclosporins: structure-activity relationships for the inhibition of the human MDR1 P-glycoprotein ABC transporter

1 reference

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Pk11195, a mitochondrial benzodiazepine receptor antagonist, reduces apoptosis threshold in Bcl-X(L) and Mcl-1 expressing human cholangiocarcinoma cells

1 reference

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High multidrug resistance protein activity in acute myeloid leukaemias is associated with poor response to chemotherapy and reduced patient survival

1 reference

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PK11195, a peripheral benzodiazepine receptor ligand, chemosensitizes acute myeloid leukemia cells to relevant therapeutic agents by more than one mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895053

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Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study

1 reference

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A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).

1 reference

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Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR.

1 reference

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Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895053

24 September 2018

PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895053

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High bcl-2 expression in acute myeloid leukemia cells correlates with CD34 positivity and complete remission rate.

1 reference

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The relationship between bcl-2 expression and response to chemotherapy in acute leukaemia.

1 reference

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Predictive value for treatment outcome in acute myeloid leukemia of cellular daunorubicin accumulation and P-glycoprotein expression simultaneously determined by flow cytometry.

1 reference

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Photometric microtiter assay of inorganic phosphate in the presence of acid-labile organic phosphates

1 reference

https://pubmed.ncbi.nlm.nih.gov/16051742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of peripheral benzodiazepine receptors in the protection of hematopoietic cells against oxygen radical damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/16051742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of a ligand selective for peripheral benzodiazepine receptors on the expression of rat hepatic P-450 cytochromes: assessment of the effect in vivo and in a hepatocyte culture system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16051742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two cellular and subcellular locations for the peripheral-type benzodiazepine receptor in rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/16051742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-operative, competitive and non-competitive interactions between modulators of P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16051742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of spontaneous and therapeutic agent-induced apoptosis with BCL-2 protein expression in acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/16051742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A low but functionally significant MDR1 expression protects primitive haemopoietic progenitor cells from anthracycline toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16051742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute myeloid leukemia in the elderly: assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy. A Southwest Oncology Group study

1 reference

https://pubmed.ncbi.nlm.nih.gov/16051742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein substrates and antagonists cluster into two distinct groups

1 reference

https://pubmed.ncbi.nlm.nih.gov/16051742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble factors elaborated by human brain endothelial cells induce the concomitant expansion of purified human BM CD34+CD38- cells and SCID-repopulating cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16051742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of the P-glycoprotein multidrug transporter with peptides and ionophores

1 reference

https://pubmed.ncbi.nlm.nih.gov/16051742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Variation in the urinary excretion of 6-beta-hydroxycortisol in humans after administration of the new isoquinoline derivative, PK-11195 (52028 RP)]

1 reference

https://pubmed.ncbi.nlm.nih.gov/16051742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topology of two DBI receptors in human lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16051742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2005-02-0711

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

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