Unraveling the cellular mechanism of insulin resistance in humans: new insights from magnetic resonance spectroscopy (Q35860394)

10 August 2017

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title

Unraveling the cellular mechanism of insulin resistance in humans: new insights from magnetic resonance spectroscopy (English)

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10 August 2017

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Gerald I Shulman

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10 August 2017

1 August 2004

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10 August 2017

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10 August 2017

19

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10 August 2017

183-190

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TRIPOD (TRoglitazone In the Prevention Of Diabetes): a randomized, placebo-controlled trial of troglitazone in women with prior gestational diabetes mellitus.

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Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction.

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Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes

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Pathogenesis of NIDDM. A balanced overview

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Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

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SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice

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Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

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Muscle-specific Pparg deletion causes insulin resistance

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IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

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Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

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Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

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Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

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Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice

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Prevention of fat-induced insulin resistance by salicylate

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Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

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Impaired glucose tolerance as a disorder of insulin action. Longitudinal and cross-sectional studies in Pima Indians.

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Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians

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The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes

21 January 2018

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Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication

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Life without white fat: a transgenic mouse

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PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

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The "thrifty genotype" in 1998

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Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

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Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

21 January 2018

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Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle

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Mitochondrial dysfunction in the elderly: possible role in insulin resistance

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Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes

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13C/31P NMR studies on the mechanism of insulin resistance in obesity

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Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

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The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

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Insulin resistance, the key to survival: a rose by any other name.

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Mechanism of free fatty acid-induced insulin resistance in humans

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Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus

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31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus

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Cellular mechanisms of insulin resistance

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Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.

21 January 2018

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Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents.

21 January 2018

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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

21 January 2018

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The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

21 January 2018

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Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

21 January 2018

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Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

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Global and societal implications of the diabetes epidemic

21 January 2018

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AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

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Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo

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27 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1152/AJPENDO.1999.276.5.E977

Identifiers

DOI

10.1152/PHYSIOL.00007.2004

1 reference

10 August 2017

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PubMed ID

15304632