Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of rel-related proteins (Q35864366)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8676482%20AND%20SRC:MED&resulttype=core&format=json

16 October 2019

title

Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of rel-related proteins (English)

1 reference

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16 October 2019

0 references

1 reference

1 reference

2

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16 October 2019

author name string

F Su

series ordinal

1

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language of work or name

English

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publication date

1 July 1996

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16 October 2019

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16 October 2019

volume

70

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16 October 2019

issue

7

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16 October 2019

page(s)

4558-4566

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The hepatitis B virus X protein increases the cellular level of TATA-binding protein, which mediates transactivation of RNA polymerase III genes.

16 October 2019

cites work

1 reference

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Hepatitis B virus pX activates NF-kappa B-dependent transcription through a Raf-independent pathway

11 July 2018

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A role for phosphorylation in the proteolytic processing of the human NF-kappa B1 precursor

11 July 2018

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Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation

11 July 2018

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Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha

11 July 2018

1 reference

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p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction

11 July 2018

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NF-kappa B and Rel: participants in a multiform transcriptional regulatory system.

11 July 2018

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Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway

11 July 2018

1 reference

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The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks.

11 July 2018

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The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B

11 July 2018

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Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex

11 July 2018

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HTLV-I encoded Tax in association with NF-kappa B precursor p105 enhances nuclear localization of NF-kappa B p50 and p65 in transfected cells.

11 July 2018

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NF-kappa B p100 (Lyt-10) is a component of H2TF1 and can function as an I kappa B-like molecule

11 July 2018

1 reference

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Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B

11 July 2018

1 reference

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Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases.

11 July 2018

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Kappa B site-dependent induction of gene expression by diverse inducers of nuclear factor kappa B requires Raf-1.

11 July 2018

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Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-kappa B2 p100 gene product: implications for viral latency

11 July 2018

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Autoregulation of I kappa B alpha activity

11 July 2018

1 reference

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Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family

11 July 2018

1 reference

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The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors

11 July 2018

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The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

11 July 2018

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High-level expression of hepatitis B virus HBx gene and hepatocarcinogenesis in transgenic mice

11 July 2018

1 reference

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Autoregulation of the NF-kappa B transactivator RelA (p65) by multiple cytoplasmic inhibitors containing ankyrin motifs

11 July 2018

1 reference

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Woodchuck hepatitis virus X protein is required for viral infection in vivo

11 July 2018

1 reference

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The sphingomyelin cycle and the second messenger function of ceramide.

11 July 2018

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NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway

11 July 2018

1 reference

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The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

11 July 2018

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Ras- and Raf-dependent activation of c-jun transcriptional activity by the hepatitis B virus transactivator pX.

11 July 2018

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Induction of cell cycle progression by hepatitis B virus HBx gene expression in quiescent mouse fibroblasts

11 July 2018

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Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors

11 July 2018

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Constitutive phosphorylation and turnover of I kappa B alpha in human T-cell leukemia virus type I-infected and Tax-expressing T cells

11 July 2018

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Transcriptional regulation of NF-kappa B2: evidence for kappa B-mediated positive and negative autoregulation

11 July 2018

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Tax induces nuclear translocation of NF-kappa B through dissociation of cytoplasmic complexes containing p105 or p100 but does not induce degradation of I kappa B alpha/MAD3

11 July 2018

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A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B

11 July 2018

1 reference

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Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade

11 July 2018

1 reference

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Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene

11 July 2018

1 reference

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Kinetic analysis of human T-cell leukemia virus type I Tax-mediated activation of NF-kappa B

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

Activation of NF-kappa B in vivo is regulated by multiple phosphorylations

11 July 2018

1 reference

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NF-kappa B: a lesson in family values

11 July 2018

1 reference

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Hepatitis B virus transactivator protein X interacts with the TATA-binding protein.

11 July 2018

1 reference

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Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation

11 July 2018

1 reference

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The X protein of hepatitis B virus coactivates potent activation domains

11 July 2018

1 reference

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Human T-cell leukemia virus type I Tax-protein-mediated activation of NF-kappa B from p100 (NF-kappa B2)-inhibited cytoplasmic reservoirs

11 July 2018

1 reference

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Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation

11 July 2018

1 reference

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Inducible nuclear expression of newly synthesized I kappa B alpha negatively regulates DNA-binding and transcriptional activities of NF-kappa B.

11 July 2018

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The hepatitis B virus X protein targets the basic region-leucine zipper domain of CREB.

11 July 2018

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The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors.

11 July 2018

1 reference

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Induction of the DNA-binding activity of c-jun/c-fos heterodimers by the hepatitis B virus transactivator pX

11 July 2018

1 reference

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Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls

11 July 2018

1 reference

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Translational control mediated by eucaryotic initiation factor-2 is restricted to specific mRNAs in transfected cells

11 July 2018

1 reference

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Trans-activation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein

11 July 2018

1 reference

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Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

11 July 2018

1 reference

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Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor

11 July 2018

1 reference

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Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism

11 July 2018

1 reference

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Transcriptional trans-activating function of hepatitis B virus.

11 July 2018

1 reference

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trans-activation of viral enhancers including long terminal repeat of the human immunodeficiency virus by the hepatitis B virus X protein

11 July 2018

1 reference

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The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs

11 July 2018

1 reference

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Hepatitis B virus X gene can transactivate heterologous viral sequences

11 July 2018

1 reference

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The HBV X-ORF encodes a transactivator: a potential factor in viral hepatocarcinogenesis.

11 July 2018

1 reference

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The identification of hepatitis B virus X gene responsive elements reveals functional similarity of X and HTLV-I tax.

11 July 2018

1 reference

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The X protein of the hepatitis B virus acts as a transcription factor when targeted to its responsive element.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

Hepatitis B virus X protein transactivates the long terminal repeats of human immunodeficiency virus types 1 and 2.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

The hepatitis B virus X-gene product trans-activates both RNA polymerase II and III promoters

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

Purified human I kappa B can rapidly dissociate the complex of the NF-kappa B transcription factor with its cognate DNA.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control

11 July 2018

1 reference

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Trans-activation of HLA-DR gene by hepatitis B virus X gene product

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

Activation of class I major histocompatibility complex gene expression by hepatitis B virus

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

An inducible 50-kilodalton NF kappa B-like protein and a constitutive protein both bind the acute-phase response element of the angiotensinogen gene

11 July 2018

1 reference

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A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

11 July 2018

1 reference

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HBx gene of hepatitis B virus induces liver cancer in transgenic mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

Hepatitis B virus X protein transactivates human interleukin-8 gene through acting on nuclear factor kB and CCAAT/enhancer-binding protein-like cis-elements

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

Cytoplasmic retention, DNA binding and processing of the NF-kappa B p50 precursor are controlled by a small region in its C-terminus

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

Human T-cell leukemia virus type I Tax induces expression of the Rel-related family of kappa B enhancer-binding proteins: evidence for a pretranslational component of regulation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

Hepatitis B virus transactivator MHBst: activation of NF-kappa B, selective inhibition by antioxidants and integral membrane localization

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

Retroviral-mediated transfer of the human acid sphingomyelinase cDNA: correction of the metabolic defect in cultured Niemann-Pick disease cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

The precursor of NF-kappa B p50 has I kappa B-like functions

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

Activation of protooncogene c-jun by the X protein of hepatitis B virus

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

Evidence in support of a role for human T-cell leukemia virus type I Tax in activating NF-kappa B via stimulation of signaling pathways

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=190392

Cloning of a mitogen-inducible gene encoding a κB DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs

24 September 2018

1 reference

12 December 2020

TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown

1 reference

12 December 2020

Adenovirus-mediated augmentation of cell transfection with unmodified plasmid vectors

1 reference

12 December 2020

Phorbol-ester-induced activation of the NF-kappa B transcription factor involves dissociation of an apparently cytoplasmic NF-kappa B/inhibitor complex

1 reference

12 December 2020

Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction

1 reference

12 December 2020

Identifiers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8676482%20AND%20SRC:MED&resulttype=core&format=json

16 October 2019

1 reference